Abstract：
:DNA vaccination is a promising alternative strategy for developing new human and animal vaccines. The massive efforts made these past 25 years to increase the immunizing potential of this kind of vaccine are still ongoing. A relatively small number of studies concerning poultry have been published. Even though there is a need for new poultry vaccines, five parameters must nevertheless be taken into account for their development: the vaccine has to be very effective, safe, inexpensive, suitable for mass vaccination and able to induce immune responses in the presence of maternal antibodies (when appropriate). DNA vaccination should meet these requirements. This review describes studies in this field performed exclusively on birds (chickens, ducks and turkeys). No evaluations of avian DNA vaccine efficacy performed on mice as preliminary tests have been taken into consideration. The review first describes the state of the art for DNA vaccination in poultry: pathogens targeted, plasmids used and different routes of vaccine administration. Second, it presents strategies designed to improve DNA vaccine efficacy: influence of the route of administration, plasmid dose and age of birds on their first inoculation; increasing plasmid uptake by host cells; addition of immunomodulators; optimization of plasmid backbones and codon usage; association of vaccine antigens and finally, heterologous prime-boost regimens. The final part will indicate additional properties of DNA vaccines in poultry: fate of the plasmids upon inoculation, immunological considerations and the use of DNA vaccines for purposes other than preventing infectious diseases.
journal_name
Vaccinejournal_title
Vaccineauthors
Meunier M,Chemaly M,Dory Ddoi
10.1016/j.vaccine.2015.11.043subject
Has Abstractpub_date
2016-01-04 00:00:00pages
202-211issue
2eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)01685-0journal_volume
34pub_type
杂志文章,评审相关文献
VACCINE文献大全abstract：:HPV vaccines are highly immunogenic. A two-dose schedule for 9-14 year-old is recommended. However, no data exist regarding the impact of age, menarche status and body mass index (BMI) on the immune response to a two-dose schedule. In this post-hoc analysis, we present antibody titers to HPV6/11/16/18 in 9-13 year-old...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2019.09.089
更新日期：2019-11-20 00:00:00
abstract：:This article presents the World Health Organization's (WHO) recommendations for pain mitigation at the time of vaccination from the WHO position paper on reducing pain at the time of vaccination: WHO position paper-September 2015, recently published in the Weekly Epidemiological Record [1]. This position paper summari...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.11.005
更新日期：2016-07-12 00:00:00
abstract：:In a severe pandemic, rapid production and deployment of vaccines will potentially be critical in mitigating the impact on populations and essential services. We compared access to vaccines and timing of delivery relative to identification of A(H1N1)pdm09 and the geographic progression of the pandemic in the WHO Europ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.06.082
更新日期：2013-08-28 00:00:00
abstract：:Treatment of cervical cancer greatly varies according to the stage of the disease. Laparoscopic surgical staging is emerging as a valid approach, compared to clinical and imaging staging, to better identify the treatment plan. Minimally invasive surgery plays the greatest role in the treatment of early cervical carcin...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2008.11.110
更新日期：2009-05-29 00:00:00
abstract：:A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eve...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2011.06.052
更新日期：2011-08-11 00:00:00
abstract：:Insoluble, nanostructured delta inulin particles enhance the immunogenicity of co-administered protein antigens and consequently are used as a vaccine adjuvant (Advax™). To better understand their immunomodulatory properties, the in vitro hydrolysis and in vivo distribution of delta inulin particles were investigated....
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.06.045
更新日期：2017-08-03 00:00:00
abstract：:Availability of vaccines may be temporarily affected by sudden peak demand, coming on top of the vast increases of regular demand that the world has witnessed; this must be addressed by sound planning, and flexibility both from manufacturers and users. Temporary shortages are not structural in nature, and capacity is ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(92)90333-f
更新日期：1992-01-01 00:00:00
abstract：:During the years 2009 and 2010 relevant epidemic waves of foot-and-mouth disease (FMD) serotype O occurred in Ecuador, representing a great drawback for the last stages of the ongoing eradication program in South America. This study describes the molecular and antigenic characterizations of 29 isolates collected from ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.08.120
更新日期：2011-10-26 00:00:00
abstract：:This study sought to explore how parents respond to competing media messages about vaccine safety. Six focus groups with mothers of infants were shown television vignettes of typical pro- and anti-vaccination claims. Thematic analysis of transcripts was undertaken. Mothers expressed surprise and concern about alleged ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.05.010
更新日期：2006-11-30 00:00:00
abstract：:In this investigation we have generated and defined the immunogenicity of two novel HIV/AIDS vaccine candidates based on the highly attenuated vaccinia virus strains, MVA and NYVAC, efficiently expressing in the same locus (TK) and under the same viral promoter the codon optimized HIV-1 genes encoding gp120 and Gag-Po...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.09.090
更新日期：2007-04-12 00:00:00
abstract：:It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(90)90101-q
更新日期：1990-08-01 00:00:00
abstract：:Flagellin of Pseudomonas aeruginosa is an important vaccine candidate. N-terminal domains are highly conserved in both type a and type b flagellins. The efficacy of gold nanoparticles (AuNPs) conjugated to N-terminal domains of P. aeruginosa flagellin (flagellin(1-161)), as an immunogen in mice, has been assessed. The...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.01.041
更新日期：2016-03-14 00:00:00
abstract：:We examined mothers' willingness to get their adolescent sons HPV vaccine. In December 2009, 2 months after approval of HPV vaccine for males, we surveyed a national sample of mothers with sons aged 9-18 (n=406). More mothers were definitely or probably willing to get their sons HPV vaccine if the vaccine were free (4...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.06.114
更新日期：2010-08-31 00:00:00
abstract：:Potential endpoints for blood stage malaria vaccine efficacy trials include uncomplicated malaria disease, which is hard to differentiate from other febrile illnesses, and mortality, which requires prohibitively large sample sizes. Strictly defined severe malaria predicts malaria-associated mortality where case fatali...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.01.054
更新日期：2004-08-13 00:00:00
abstract：INTRODUCTION:Online media may influence women's decision to undergo vaccination during pregnancy. The aims of this mixed-methods study were to: (1) examine the portrayal of maternal vaccination in online media and (2) establish the perceived target of vaccine protection as viewed by pregnant women and maternity healthc...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.10.092
更新日期：2018-11-29 00:00:00
abstract：BACKGROUND:Poliomyelitis is endemic in Northern Nigeria where there is continuous transmission of wild poliovirus 1 and 3 (WPV1 and 3) and circulating vaccine derived poliovirus 2 (cVDPV2) resulting in a high number of cases of children with acute flaccid paralysis. The seroprevalence of antibodies to polio serotypes w...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.023
更新日期：2012-11-06 00:00:00
abstract：:This study evaluated the attenuated Salmonella Enteritidis (SE) ghost strain JOL2114 (Δlon ΔcpxR Δasd), which displays on the bacterial surface the H1N1 hemagglutinin globular head portion (HA1; amino acid residues 63-286) on the bacterial surface for protective efficacy against Salmonella and H1N1 challenge in the ch...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.04.077
更新日期：2020-06-09 00:00:00
abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV) poses a great threat to public health due to its high mortality and transmission rate and wide geographical distribution. There is currently no specific antiviral therapy for CCHF. This study provides the first in-depth analysis of the cellular and humoral immune response ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.08.003
更新日期：2012-09-28 00:00:00
abstract：:Routine administration of the quadrivalent human papillomavirus (HPV) vaccine has been recommended for 11-12-year-old males since 2011, but coverage remains low. In a U.S. national sample of parents of 11-17-year-old males (n=779), 78.6% of parents reported their sons had not received the HPV vaccine. The most common ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.05.035
更新日期：2014-06-30 00:00:00
abstract：:In Bangladesh, full vaccination rates among children living in rural hard-to-reach areas and urban streets are low. We conducted a quasi-experimental pre-post study of a 12-month mobile phone intervention to improve vaccination among 0-11 months old children in rural hard-to-reach and urban street dweller areas. Softw...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.11.024
更新日期：2016-01-04 00:00:00
abstract：:The immunogenicity and protective efficacy of a nucleic acid vaccine encoding the herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene under the control of the CMV immediate early gene promoter was examined. Mice immunized three times by intramuscular injection with the vaccine developed an HSV specific IgG bu...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00027-8
更新日期：1996-09-01 00:00:00
abstract：:Viral hemorrhagic septicemia (VHS) in olive flounder (Paralichthys olivaceus) remains an unsolved health problem in Korean aquaculture. Vaccination plays a significant role in modern aquaculture, and the duration of protection provided is of vital importance. Here, we have demonstrated the efficacy, duration of protec...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.07.036
更新日期：2013-09-23 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Parents' attitudes toward MMR vaccine and measles, mumps and rubella infections relate to their child's MMR status, therefore improving these attitudes is central to improving current suboptimal MMR uptake. However, no study has yet combined evidence-based, comprehensive and psychometrically va...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.12.030
更新日期：2011-02-11 00:00:00
abstract：:We examined potential risk factors on vaccine virus shedding and antibody seroresponse to human rotavirus vaccine (Rotarix) in Mexican infants. Two doses of Rotarix were administered to infants during the first two visits for their routine childhood immunization (∼8 and 15weeks of age) in Mexico City. Infant's charact...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.09.006
更新日期：2016-10-17 00:00:00
abstract：:The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine can...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.04.088
更新日期：2015-09-29 00:00:00
abstract：BACKGROUND:Vaccination coverage is the usual metrics to evaluate the immunization programs performance. For the 10-valent pneumococcal conjugate (PCV10) vaccine, measuring the delay of vaccination is also important, particularly as younger children are at increased risk of disease. Routinely collected administrative da...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.01.012
更新日期：2017-02-15 00:00:00
abstract：:The identification of MHC class II-restricted peptides has become a priority for the development of peptide-based prophylactic and therapeutic vaccines. The aim of this study was to assess the correlations between peptide-binding assays on purified HLA II molecules and immunization of human HLA II transgenic mice defi...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.11.048
更新日期：2006-03-20 00:00:00
abstract：:Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seas...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2015.12.009
更新日期：2016-02-03 00:00:00
abstract：:'Children represent the most vulnerable segment of every society--and they are our present and future. Good health, especially of children, promotes personal and national development. Scientific progress, matched with improved capacities of all countries to immunize their children, provides an unparalleled opportunity...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(92)90323-c
更新日期：1992-01-01 00:00:00
abstract：:Three proteins of PE and PPE families of Mycobacterium tuberculosis were evaluated for their ability to induce T cell responses in mice. To enhance immunity induced by protein immunization, we tested the efficacy of adjuvant Ribi (monophosphoryl lipid A+TDM), along with three proteins of the PE/PPE family. Balb/c mice...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.07.026
更新日期：2007-10-10 00:00:00
