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Lessons learned in the analysis of high-dimensional data in vaccinomics.

Abstract：

:The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine candidates. However, the application of systems biology to what has been termed "big data," or "high-dimensional data," is not without significant challenges-chief among them a paucity of gold standard analysis and modeling paradigms with which to interpret the data. In this article, we relate some of the lessons we have learned over the last decade of working with high-dimensional, high-throughput data as applied to the field of vaccinomics. The value of such efforts, however, is ultimately to better understand the immune mechanisms by which protective and non-protective responses to vaccines are generated, and to use this information to support a personalized vaccinology approach in creating better, and safer, vaccines for the public health.

journal_name

Vaccine

journal_title

Vaccine

authors

Oberg AL,McKinney BA,Schaid DJ,Pankratz VS,Kennedy RB,Poland GA

doi

10.1016/j.vaccine.2015.04.088

subject

Has Abstract

pub_date

2015-09-29 00:00:00

pages

5262-70

issue

40

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(15)00574-5

journal_volume

33

pub_type

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