Abstract：
:We previously described that an inactivated vaccine against heartwater prepared from Cowdria ruminantium (Crystal Springs strain) organisms and administered in complete Freund's adjuvant (cFA) protected sheep against homologous needle challenge. Further studies, described herein, demonstrated that this vaccine protected 100% of sheep against death on challenge with laboratory-infected ticks and with field ticks in a heartwater endemic farm, whereas a mortality rate of 44% and 62%, respectively, was recorded in the control sheep. Subsequently, the Mbizi strain of C. ruminantium was incorporated into the vaccine because of its wider cross-protective capacity, and trial data suggested that protection may be achieved against challenge with diverse geographical strains using this strain. The efficacy of five adjuvants with acceptable safety was compared with that of cFA. Against a homologous intravenous challenge, highest survival rates were observed in sheep vaccinated with inactivated C. ruminantium in either cFA, Montanide ISA 50 or Quil A. The vaccine prepared in Montanide ISA 50 protected six of seven sheep against natural challenge from field ticks on a farm in Zimbabwe where heartwater is endemic, whereas six of seven control sheep died (P = 0.029). These data support optimization of the vaccine prepared in Montanide ISA 50, followed by evaluation of its efficacy in all target domestic ruminant species and in other geographical regions where heartwater constrains livestock production.
journal_name
Vaccinejournal_title
Vaccineauthors
Mahan SM,Kumbula D,Burridge MJ,Barbet AFdoi
10.1016/s0264-410x(98)80120-5subject
Has Abstractpub_date
1998-07-01 00:00:00pages
1203-11issue
11-12eissn
0264-410Xissn
1873-2518pii
S0264-410X(98)80120-5journal_volume
16pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Because of demonstrable cross-reactivity of cellular antigens contained in B subunit-killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines with antigens of various non-cholera species of the family Vibrionaceae (NCV), the protection conferred by the vaccines against diarrhoea associated with ...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(89)90048-0
更新日期：1989-04-01 00:00:00
abstract：:DNA vectors can be used to deliver vaccine antigens that stimulate effective protective immunity in mice, but in larger, outbred animal species, the protective efficacy is lower or large doses of DNA are required. These data demonstrate that porcine interleukin-3 (IL-3) when delivered to pigs by DNA vector or in low d...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.01.023
更新日期：2006-04-12 00:00:00
abstract：:Clinical and serum antibody responses following intramuscular injection of two formulations of Salmonella typhi Vi capsular polysaccharide (Vi) were assessed in a double-blind evaluation. Healthy adults were randomly assigned to receive a 25 micrograms dose of liquid (Vi-Liq; n = 182) or freeze-dried Vi vaccine (Vi-Ly...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(94)90194-5
更新日期：1994-01-01 00:00:00
abstract：:The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine can...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.04.088
更新日期：2015-09-29 00:00:00
abstract：:In 2003 Italy adopted the National Plan for Measles and Congenital Rubella Elimination, but some outbreaks of measles are still occurring, as the target coverage rate (≥ 95%) for new-borns has currently not been achieved. In order to support the monitoring of the measles elimination programme, the authors carried out ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.03.011
更新日期：2016-04-19 00:00:00
abstract：:The expression and secretion of pertussis toxin subunits S1 to S5 in Bacillus subtilis by the aid of a bacillary signal sequence has been reported. While secretion of subunit S1 was high, that of others was low. Ways have now been explored to improve the yield, using S4 as an example. The addition of a protease inhibi...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(90)90017-g
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND:Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. METHODS:Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and e...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.03.007
更新日期：2019-04-17 00:00:00
abstract：:This study evaluated the seroprevalence of poliovirus types 1, 2 and 3 antibodies and vaccination coverage in 780 subjects aged between 7 months and 39 years in Montevideo, Uruguay, where oral polio vaccine (OPV) is used. Antibody titers were measured and seroprotection rates and geometric mean titers (GMTs) were comp...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.02.042
更新日期：2009-05-05 00:00:00
abstract：:Safety of and humoral immune response to the anti-influenza vaccine in coronary artery disease (CAD) patients were evaluated. The trivalent vaccine was administered to 137 eligible CAD patients and 67 age- and sex-matched healthy individuals. Antibody (Ab) titers were measured before and 1 month after vaccination. CAD...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.09.108
更新日期：2009-12-10 00:00:00
abstract：:Endospores of the Gram-positive bacterium, Bacillus subtilis, have been used successfully for delivery of antigens where the immunogen is expressed on the spore surface. In this work the spore has been engineered to deliver antigens to the cytoplasm of macrophages by expressing listeriolysin O (LLO) or a derivative, L...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.09.024
更新日期：2008-11-11 00:00:00
abstract：:Infectious laryngotracheitis virus (ILTV) is an alphaherpesvirus that causes acute respiratory disease in chickens worldwide. The virus is horizontally transmitted and causes large outbreaks of disease. Recent studies have shown that a glycoprotein G deficient candidate vaccine strain of ILTV (ΔgG ILTV) is safe and pr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.06.002
更新日期：2011-08-05 00:00:00
abstract：:Current available influenza vaccines are safe and effective in preventing influenza. Nevertheless, there is a need for influenza vaccines with improved efficacy in the elderly. This need is underscored by both the observation that influenza has a major clinical and economic impact in the elderly and the fact that curr...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.vaccine.2005.04.020
更新日期：2005-07-08 00:00:00
abstract：:Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of e...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)90336-0
更新日期：1994-08-01 00:00:00
abstract：BACKGROUND:Human papillomavirus (HPV) vaccines have been recommended as primary prevention of HPV-related cancers for over 10 years in the United States, and evidence reveals decreased incidence of HPV infections following vaccination. However, concerns have been raised that HPV vaccines could decrease fertility. This ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.03.035
更新日期：2020-05-19 00:00:00
abstract：:Foot-and-mouth disease (FMD) is a highly contagious vesicular disease that affects domestic and wild cloven-hoofed animals worldwide. Recently, a series of outbreaks of type A FMDV occurred in Southeast Asian countries, China, the Russia Federation, Mongolia, Kazakhstan and South Korea. The FMD virus (A/GDMM/CHA/2013)...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.09.055
更新日期：2015-10-26 00:00:00
abstract：:DNA vaccination is a promising alternative strategy for developing new human and animal vaccines. The massive efforts made these past 25 years to increase the immunizing potential of this kind of vaccine are still ongoing. A relatively small number of studies concerning poultry have been published. Even though there i...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2015.11.043
更新日期：2016-01-04 00:00:00
abstract：:It has been hypothesized that antibody induced by Plasmodium falciparum circumsporozoite protein vaccine would be effective against endemic human malaria. In a malaria endemic region of Kenya, 76 volunteers, in 38 pairs sleeping adjacently, were immunized with subunit circumsporozoite protein Asn-Ala-Asn-Pro tetrapept...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(95)00221-l
更新日期：1996-06-01 00:00:00
abstract：:Intranasal live attenuated influenza vaccine (LAIV) has potential for self-administration (SA) by adults and adolescents, which could save time and cost in mass vaccination settings. Participants in a study of LAIV in adults (n=4561) selected either SA or health care provider (HCP) administration and were followed for...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2012.12.028
更新日期：2013-01-30 00:00:00
abstract：OBJECTIVES:We aimed to estimate vaccine effectiveness against severe measles based on the number of vaccine doses administered and the time since last vaccination. PATIENTS AND METHODS:We included measles cases aged at least 2 years and born since 1980 who were notified in France between 2006 and mid-2019. We consider...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.05.005
更新日期：2020-06-15 00:00:00
abstract：BACKGROUND:While the size and type of a vaccine container (i.e., primary container) can have many implications on the safety and convenience of a vaccination session, another important but potentially overlooked consideration is how the design of the primary container may affect the distribution of the vaccine, its res...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.04.018
更新日期：2015-06-22 00:00:00
abstract：BACKGROUND:Roughly half of U.S. adults do not receive recommended booster vaccinations, but protective antibody levels are rarely measured in adults. Demographic factors, vaccination history, and responses to other vaccinations could help identify at-risk individuals. We sought to characterize rates of seroconversion a...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.08.005
更新日期：2014-09-29 00:00:00
abstract：:In this work, we explored the potential of cationic solid lipid nanoparticles (cSLN) as efficient adjuvants for inactivated foot and mouth disease virus (iFMDV) vaccine. The cSLN were prepared by O/W emulsion method with Compritol 888 ATO as lipid matrix, and were modified by cationic lipid Didodecyldimethylammonium b...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.02.004
更新日期：2020-03-04 00:00:00
abstract：:Immunization of boars against GnRH inhibits synthesis of testicular anabolic steroids and the sex odour androstenone. Time between second vaccination and return of Leydig cell function is unknown. Six catheterized boars received the second dose (Improvac) at 26 weeks of age (day 0). Titre, LH, testicular steroids, and...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.05.085
更新日期：2008-08-18 00:00:00
abstract：:There has been controversy about whether cognitive changes occur in early human immunodeficiency virus (HIV) disease. In those studies reporting cognitive changes, these are typically subclinical, and their relationship to daily and/or occupational functioning has not been addressed. The potential effects of changes m...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(93)90231-l
更新日期：1993-01-01 00:00:00
abstract：:Information provided by most influenza vaccine manufacturers do not reflect the recommendations of WHO and/or national public health advisory groups with regard to the use of influenza vaccines in pregnant or lactating women. The majority of vaccines contain precautionary language which could discourage use in pregnan...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2016.08.042
更新日期：2016-10-26 00:00:00
abstract：:Clostridium difficile is a pathogen with increasing severity for which host antibody responses provide protection from disease. DNA vaccination has several advantages compared to traditional vaccine methods, however no study has examined this platform against C. difficile toxins. A synthetic gene was created encoding ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.03.058
更新日期：2009-06-02 00:00:00
abstract：INTRODUCTION:Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. In 2011, almost half of the 9943 measles cases in China occurred in children eligible for measles vaccination. We conduct...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.vaccine.2016.02.005
更新日期：2016-12-12 00:00:00
abstract：:Malaria transmission-blocking vaccines (TBV) targeting sexual stages of the parasite represent an ideal intervention to reduce the burden of the disease and eventual elimination at the population level in endemic regions. Immune responses against sexual stage antigens impair the development of parasite inside the mosq...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.08.025
更新日期：2015-09-22 00:00:00
abstract：BACKGROUND:The 2015/2016 influenza season was characterized in Europe by the circulation of A(H1N1)pdm09 clade 6B.1 and B/Victoria-lineage influenza viruses. The components of the vaccines used in the current and past two seasons in the Valencia region were similar but not well matched to the 2015/2016 dominant influen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.10.100
更新日期：2017-12-19 00:00:00
abstract：:A novel recombinant hepatitis B vaccine, trademarked Sci-B-Vac, was evaluated for safety, tolerability and immunogenicity in an open label trial performed in Singapore. The experimental vaccine, derived from Chinese hamster ovary (CHO) cells, consists of hepatitis B surface antigen (HBsAg) particles harbouring all thr...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(92)90391-v
更新日期：1992-01-01 00:00:00
