Expression of pertussis toxin subunit S4 as an intracytoplasmic protein in Bacillus subtilis.

abstract：:Based on the reactivities of monoclonal antibodies, we previously reported that 25 Japanese encephalitis (JE) virus strains fell into five antigenic groups: Nakayama, Beijing-1, Kamiyama, 691004 and Muar. In the present study, we produced monoclonal antibodies against the Beijing-1 strain and obtained the Beijing-1 gr...

journal_title：Vaccine

authors： Satake Y,Hasegawa H,Yoshida M,Kobayashi Y

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:In the UK, the childhood immunisation programme is given in the first 5 years of life and protects against 12 vaccine-preventable diseases. Recently, this programme has undergone changes with addition of vaccination against Meningitis B from September 2015 and the removal of the primary dose of protection ag...

journal_title：Vaccine

authors： Panovska-Griffiths J,Crowe S,Pagel C,Shiri T,Grove P,Utley M

更新日期：2018-08-23 00:00:00

abstract：:Development of meningococcal serogroups A, C, W-135 and Y conjugate vaccines could expand coverage against devastating meningococcal diseases. The immunogenicity of one dose of each one of five MenACWY-TT formulations versus a licensed ACWY polysaccharide vaccine was evaluated in 175 healthy subjects of 15-25 years. S...

journal_title：Vaccine

authors： Ostergaard L,Lebacq E,Poolman J,Maechler G,Boutriau D

更新日期：2009-01-01 00:00:00

abstract：:A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73...

journal_title：Vaccine

authors： Cainelli Gebara VC,Risoléo L,Lopes AP,Ferreira VR,Quintilio W,Lépine F,Silva WD,Raw I

更新日期：2007-01-08 00:00:00

abstract：:Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after intramuscular inoculation. Several adjuvan...

journal_title：Vaccine

authors： Xiong Q,Wei Y,Xie H,Feng Z,Gan Y,Wang C,Liu M,Bai F,Xie F,Shao G

更新日期：2014-06-05 00:00:00

abstract：:In accordance with the end game strategies for polio eradication a synchronized switch plan from tOPV to bOPV was implemented globally in 2016. The National Committee for Polio Eradication (NCCPE) validated the switch activities in India. An expert group of 104 academics conducted field visits in 25 states and 2 Union...

journal_title：Vaccine

authors： Dasgupta R,Sharma S,Sharma N,Banerjee K,Haran EGP,Muliyel JP,Salunke S,Masoodi MA,Haldar P,Bahl S,Bhatnagar P,Joshi S,Arora NK

更新日期：2019-04-17 00:00:00

abstract：:The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(O...

journal_title：Vaccine

authors： Zhang CH,Lu JH,Wang YF,Zheng HY,Xiong S,Zhang MY,Liu XJ,Li JX,Wan ZY,Yan XG,Qi SY,Cui Z,Zhang B

更新日期：2005-05-02 00:00:00

abstract：:Seasonal influenza epidemics are associated with high morbidity and mortality particularly in high-risk patients. Conventionally administered influenza vaccines show reduced efficacy in populations with weakened immune systems such as solid-organ transplant patients. This study assesses the safety and immunogenicity o...

journal_title：Vaccine

authors： Morelon E,Pouteil Noble C,Daoud S,Cahen R,Goujon-Henry C,Weber F,Laurent PE,Kaiserlian D,Nicolas JF

更新日期：2010-10-04 00:00:00

abstract：:Passive immunization of mice with 131 micrograms of the non-neutralizing monoclonal antibody (mAb) 18A2B2, directed against the A subgroup epitope of the G glycoprotein of respiratory syncytial virus Long strain (RSV), confers protection against viral i.n. challenge. The role of the Fc fragment of this antibody as wel...

journal_title：Vaccine

authors： Corbeil S,Seguin C,Trudel M

更新日期：1996-04-01 00:00:00

abstract：:ADVAX is a DNA-based candidate HIV vaccine that was safe but weakly immunogenic when delivered intramuscularly (IM) in humans. Studies were performed in animal models to determine whether an alternative delivery method, in vivo electroporation (EP), could improve the immunogenicity of ADVAX while maintaining an accept...

journal_title：Vaccine

authors： Dolter KE,Evans CF,Ellefsen B,Song J,Boente-Carrera M,Vittorino R,Rosenberg TJ,Hannaman D,Vasan S

更新日期：2011-01-17 00:00:00

abstract：INTRODUCTION:New vaccine introductions have put strains on vaccine supply chains around the world. While increasing storage and transportation may be the most straightforward options, it is also important to consider what financial and operational benefits can be incurred. In 2012, suboptimal vaccine coverage and impen...

journal_title：Vaccine

authors： Brown ST,Schreiber B,Cakouros BE,Wateska AR,Dicko HM,Connor DL,Jaillard P,Mvundura M,Norman BA,Levin C,Rajgopal J,Avella M,Lebrun C,Claypool E,Paul P,Lee BY

更新日期：2014-07-07 00:00:00

abstract：:We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged

journal_title：Vaccine

authors： Hsieh YC,Lin PY,Chiu CH,Huang YC,Chang KY,Liao CH,Chiu NC,Chuang YC,Chen PY,Chang SC,Liu JW,Yen MY,Wang JH,Liu CY,Lin TY

更新日期：2009-09-04 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of serious acute lower respiratory illness in infants and young children and a significant cause of disease burden in the elderly and immunocompromised. There are no licensed RSV vaccines to address this significant public health need. While advances in vaccin...

journal_title：Vaccine

authors： Roberts JN,Graham BS,Karron RA,Munoz FM,Falsey AR,Anderson LJ,Marshall V,Kim S,Beeler JA

更新日期：2016-09-22 00:00:00

abstract：BACKGROUND:China is the most populous country in the world, with an annual birth cohort of approximately 16 million, requiring an average of 500 million vaccine doses administered annually. In China, over 30 domestic and less than 10 overseas vaccine manufacturers supply over 60 licensed vaccine products, representing ...

journal_title：Vaccine

authors： Guo B,Page A,Wang H,Taylor R,McIntyre P

更新日期：2013-01-11 00:00:00

abstract：:The bacillus Calmette Guérin (BCG) vaccine, the only licensed vaccine against TB, displays partial and variable efficacy, thus making the exploitation of novel vaccination strategies a major priority. Most of the current vaccines in pre-clinical or clinical development are based on the induction of T cells recognizing...

journal_title：Vaccine

authors： Larrouy-Maumus G,Layre E,Clark S,Prandi J,Rayner E,Lepore M,de Libero G,Williams A,Puzo G,Gilleron M

更新日期：2017-03-07 00:00:00

abstract：:This work describes the optimization of a cost-effective process for the production of an inactivated bacterial vaccine against heartwater and the first attempt to produce the causative agent of this disease, the rickettsia Ehrlichia ruminantium (ER), using stirred tanks. In vitro, it is possible to produce ER using c...

journal_title：Vaccine

authors： Marcelino I,Sousa MF,Veríssimo C,Cunha AE,Carrondo MJ,Alves PM

更新日期：2006-03-06 00:00:00

abstract：:To study the regulation of the human immune response to hepatitis B surface antigen (HBsAg) we have carefully monitored the in vivo humoral and in vitro cellular immune responses to HBsAg in 50 subjects receiving four doses of hepatitis B vaccine according to a 0, 1, 2, 12 month vaccination scheme. Twenty-three subjec...

journal_title：Vaccine

authors： Leroux-Roels G,Van Hecke E,Michielsen W,Voet P,Hauser P,Pêtre J

更新日期：1994-07-01 00:00:00

abstract：:Vaccines reside in a complex multiscale system that includes biological, clinical, behavioral, social, operational, environmental, and economical relationships. Not accounting for these systems when making decisions about vaccines can result in changes that have little effect rather than solutions, lead to unsustainab...

journal_title：Vaccine

authors： Lee BY,Mueller LE,Tilchin CG

更新日期：2017-01-20 00:00:00

abstract：:Respiratory syncytial virus causes a significant public health burden, particularly in very young infants and the frail elderly. The legacy of enhanced RSV disease (ERD) from a whole formalin-inactivated RSV vaccine, and the complex biology of the virus and the neonate have delayed the development of effective vaccine...

journal_title：Vaccine

authors： Graham BS

更新日期：2016-06-24 00:00:00

abstract：INTRODUCTION:Replication-competent vaccinia viruses (VACVs) show prolonged antigen expression time and greater stimulation of immune responses than their replication-incompetent counterparts. However, there is the potential risk of serious post-vaccination complications, especially for children and immunocompromised in...

journal_title：Vaccine

authors： Zhang Q,Liu Z,Hou J,Wang S,Liu C,Wei M,Liu Y,Shao Y

更新日期：2016-06-24 00:00:00

abstract：:Influenza A viruses pose a substantial threat to the human population whether by purposeful manipulation and release or by the natural process of interspecies transmissions from animal reservoirs. The challenge with preparing for these events with vaccination strategies is that the best forms of protective immunity ta...

journal_title：Vaccine

authors： Ellebedy AH,Webby RJ

更新日期：2009-11-05 00:00:00

abstract：:ErbB-2 is associated with several solid tumours of which breast cancer is the commonest cancer in women worldwide. Though anti-ErbB-2 antibody appears to play a significant role in prevention and therapy, naturally occurring anti-ErbB-2 antibody associated with the cleaved ectodomain of overexpressed ErbB-2 self antig...

journal_title：Vaccine

authors： Mukhopadhyay A,Dyring C,Stott DI

更新日期：2014-02-12 00:00:00

abstract：BACKGROUND:Routine administration of all age-appropriate doses of vaccines during the same visit is recommended for children by the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP). METHODS:Evaluate the potentially achievable vaccination coverage for ≥4 doses of di...

journal_title：Vaccine

authors： Zhao Z,Smith PJ,Hill HA

更新日期：2016-06-08 00:00:00

abstract：:A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...

journal_title：Vaccine

authors： Edmunds WJ,Brisson M,Melegaro A,Gay NJ

更新日期：2002-01-31 00:00:00

abstract：:Pseudorabies Virus (PRV) is the causative agent of Pseudorabies (PR), also known as Aujeszky's Disease, one of the most important infectious diseases in swine, resulting in huge economic losses to the swine industry globally. The emergence of mutant PRV strains after 2011 resulted in a sharp decrease in the efficacy o...

journal_title：Vaccine

authors： Zhang T,Liu Y,Chen Y,Wang A,Feng H,Wei Q,Zhou E,Zhang G

更新日期：2020-09-03 00:00:00

abstract：:Killed whole-cell preparations were used as bacterins against leptospirosis. As this type of protection is considered to be serogroup-specific, several serogroups were added to the usual vaccines, and the most pathogenic serovar was chosen for each group. Different leptospire extracts were evaluated for their protecti...

journal_title：Vaccine

authors： Sonrier C,Branger C,Michel V,Ruvoën-Clouet N,Ganière JP,André-Fontaine G

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Sexual mixing between heterogeneous population subgroups is an integral component of mathematical models of sexually transmitted infections (STIs). This study compares the fit of different mixing representations to survey data and the impact of different mixing assumptions on the predicted benefits of hypoth...

journal_title：Vaccine

authors： Easterly CW,Alarid-Escudero F,Enns EA,Kulasingam S

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:Household-based caregivers serve an important role in protecting the health of cancer patients, who may be vulnerable to infectious diseases due to their cancer treatments. Caregiver preventive care should be prioritized to maintain continuity of care and to reduce potential for transmission of infectious di...

journal_title：Vaccine

authors： Marellapudi A,King AR,Bednarczyk RA

更新日期：2020-09-11 00:00:00

abstract：:Recipients of renal transplants were vaccinated with 20 ng hepatitis B surface antigen aluminium-adsorbed vaccine in order to gauge their resistance to hepatitis B infection, to which these patients are at high risk. The patients were given three 40 micrograms doses of the vaccine over a period of six months and their...

journal_title：Vaccine

authors： Feuerhake A,Muller R,Lauchart W,Pichlmayr R,Schmidt FW

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:In South Africa, influenza vaccination is recommended to all diabetics. However, vaccination coverage among diabetics remains low. Therefore, this study aimed to explore the knowledge, attitudes, and practices among people with diabetes in Pretoria regarding seasonal influenza and influenza vaccination. MET...

journal_title：Vaccine

authors： Olatunbosun OD,Esterhuizen TM,Wiysonge CS

更新日期：2017-11-07 00:00:00