Adjuvant and immunogenic activities of the 73kDa N-terminal alpha-domain of BrkA autotransporter and Cpn60/60kDa chaperonin of Bordetella pertussis.

abstract：:DNA vaccines have considerable potential for the prophylaxis and therapy of a range of diseases, but their potential has not been realised largely due to poor immunogenicity. Fas ligand is a pro-apoptotic molecule, able to induce death of Fas expressing cells. We describe the construction of a DNA vaccine encoding a c...

journal_title：Vaccine

authors： Nimal S,Thomas MS,Heath AW

更新日期：2007-03-08 00:00:00

abstract：BACKGROUND:Efforts to develop a Clostridium difficile vaccine are underway; identification of patients at risk for C. difficile infection (CDI) is critical to inform vaccine trials. We identified groups at high risk of CDI ≥ 2 8 days after hospital discharge. METHODS:Hospital discharge data and pharmacy data from two ...

journal_title：Vaccine

authors： Baggs J,Yousey-Hindes K,Ashley ED,Meek J,Dumyati G,Cohen J,Wise ME,McDonald LC,Lessa FC

更新日期：2015-11-17 00:00:00

abstract：:Biological therapy options for the treatment of rheumatic disease target molecules that can affect the cross-talk between innate and adaptive immune responses upon vaccination. Influenza vaccination in children with rheumatic disease has been recommended, but there are only sparse data on the quality of vaccine respon...

journal_title：Vaccine

authors： Laestadius Å,Ingelman-Sundberg HM,Myrberg IH,Verme A,Sundberg E,Schweiger B,Saghafian-Hedengren S,Nilsson A

更新日期：2019-06-19 00:00:00

abstract：:The immunogenicity of two vector-based vaccines, either given alone or in a prime-boost regimen, was investigated. Cynomolgus macaques were immunised with modified vaccinia virus Ankara (MVA) expressing simian immunodeficiency virus (SIV)macJ5 env, gag-pol, nef, rev, and tat genes (MVA-SIVmac) or primed with a Semliki...

journal_title：Vaccine

authors： Nilsson C,Mäkitalo B,Berglund P,Bex F,Liljeström P,Sutter G,Erfle V,ten Haaft P,Heeney J,Biberfeld G,Thorstensson R

更新日期：2001-05-14 00:00:00

abstract：:This study was aimed to evaluate the efficacy and immunogenicity of combined hepatitis B vaccination with plasma-derived vaccine (PDV) and recombinant vaccine (RV). A total of 329 infants was recruited, including 224 high-risk infants born to hepatitis B e antigen-positive mothers and 105 low-risk infants born to hepa...

journal_title：Vaccine

authors： Lee PI,Lee CY,Huang LM,Chen JM,Chang MH

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Although global progress in measles control has been realized, achieving elimination has proven difficult in many regions of the world. China has adopted a goal of measles elimination but recent outbreaks predominantly affecting children <8 months who are ineligible for vaccination and incompletely protected...

journal_title：Vaccine

authors： Janusz CB,Wagner AL,Masters NB,Ding Y,Zhang Y,Hutton DW,Boulton ML

更新日期：2020-06-15 00:00:00

abstract：:Cervical cancer that is associated with high-risk human papillomaviruses (HPV) is the most common malignancy in Indian women. Therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. However, relatively little is known about the prevalence of the different H...

journal_title：Vaccine

authors： Gheit T,Vaccarella S,Schmitt M,Pawlita M,Franceschi S,Sankaranarayanan R,Sylla BS,Tommasino M,Gangane N

更新日期：2009-01-29 00:00:00

abstract：:Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine in 148 healthy adult volunteers. All candidate vaccine formulations had a good safety profile and were well tolerat...

journal_title：Vaccine

authors： Moutschen M,Léonard P,Sokal EM,Smets F,Haumont M,Mazzu P,Bollen A,Denamur F,Peeters P,Dubin G,Denis M

更新日期：2007-06-11 00:00:00

abstract：:This article presents the World Health Organization's (WHO) recommendations for the use of vaccines against diseases caused by human papillomaviruses (HPV) from the WHO position paper on Human papillomavirus vaccines: WHO position paper - October 2014, recently published in the Weekly Epidemiological Record [1]. This ...

journal_title：Vaccine

authors：

更新日期：2015-08-26 00:00:00

abstract：:In the last quarter of the year 2000, the meningococcal C conjugated vaccine was incorporated into the routine vaccination schedule in Catalonia (at 2, 4 and 6 months). In addition a vaccination campaign was carried out in children <6 years of age, with a coverage of 96.2%. The effectiveness of the vaccination in this...

journal_title：Vaccine

authors： Salleras L,Domínguez A,Cardeñosa N

更新日期：2003-01-30 00:00:00

abstract：:Serum specimens of 1075 young adults representing nursing and medical staff were collected for determination of rubella immunity using the radial haemolysis (RH) technique, also know as the haemolysis in gel (HIG) test. Of the sera 84 (7.8%) were negative (RH titre less than 4 mm) and an additional 93 (8.7%) gave an R...

journal_title：Vaccine

authors： Väänänen P,Mäkelä P,Vaheri A

更新日期：1986-03-01 00:00:00

abstract：:Edwardsiella tarda is an important fish pathogen that causes extensive losses in farmed fish around the world. Various types of vaccines have been developed against E. tarda infection, such as inactivated vaccine, live attenuated vaccine and subunit vaccine. However, inactivated vaccine exhibits poor immune protection...

journal_title：Vaccine

authors： Liu X,Zhang H,Jiao C,Liu Q,Zhang Y,Xiao J

更新日期：2017-01-05 00:00:00

abstract：:In 2003 Italy adopted the National Plan for Measles and Congenital Rubella Elimination, but some outbreaks of measles are still occurring, as the target coverage rate (≥ 95%) for new-borns has currently not been achieved. In order to support the monitoring of the measles elimination programme, the authors carried out ...

journal_title：Vaccine

authors： Tafuri S,Gallone MS,Gallone MF,Pappagallo MT,Larocca A,Germinario C

更新日期：2016-04-19 00:00:00

abstract：OBJECTIVE:To compare the use of four different social media sites to recruit men who have sex with men (MSM) and transgender women to a phase 2b HIV prevention vaccine trial, HVTN 505. DESIGN:Retrospective, observational study. METHODS:The University of Pennsylvania HIV Vaccine Trials Unit (Penn HVTU) employed street...

journal_title：Vaccine

authors： Buckingham L,Becher J,Voytek CD,Fiore D,Dunbar D,Davis-Vogel A,Metzger DS,Frank I

更新日期：2017-06-14 00:00:00

abstract：:In this study, the impact of Th1-inducing cytokine gene co-delivery and antigen boosting on humoral and cellular responses induced by multiepitopic DNA immunization in mice have been investigated. Intramuscular injection of mixed DNA constructs encoding for HIV-1 Gag, Tat and Nef proteins, co-administered with the DNA...

journal_title：Vaccine

authors： Billaut-Mulot O,Idziorek T,Loyens M,Capron A,Bahr GM

更新日期：2001-04-06 00:00:00

abstract：:Enterotoxigenic E. coli (ETEC) are an important cause of diarrhea in developing countries, especially among indigenous children and travelers. In this randomized, double-blind, placebo-controlled trial, a live, attenuated CS1/CS3 ETEC strain, PTL-003, was tested as a potential vaccine strain. Thirty-three subjects dra...

journal_title：Vaccine

authors： McKenzie R,Darsley M,Thomas N,Randall R,Carpenter C,Forbes E,Finucane M,Sack RB,Hall E,Bourgeois AL

更新日期：2008-08-26 00:00:00

abstract：INTRODUCTION:In 2005, in Finland, the whole-cell pertussis vaccine was replaced by acellular given at 3-5-12months, and boosters at 4 and 11-15years of age. From July 2012, military conscripts have been offered a pertussis booster dose. Conscription is mandatory for Finnish men, and >95% were 19-21years old when enroll...

journal_title：Vaccine

authors： Zöldi V,Sane J,Nohynek H,Virkki M,Hannila-Handelberg T,Mertsola J

更新日期：2017-09-18 00:00:00

abstract：BACKGROUND:Adjuvants like AS01B increase the immunogenicity of vaccines and generally cause increased transient reactogenicity compared with Alum. A phase II randomized trial was conducted to characterize the response to AS01B and Alum adjuvanted vaccines. A post-hoc analysis was performed to examine the associations b...

journal_title：Vaccine

authors： Burny W,Marchant A,Hervé C,Callegaro A,Caubet M,Fissette L,Gheyle L,Legrand C,Ndour C,Tavares Da Silva F,van der Most R,Willems F,Didierlaurent AM,Yarzabal J,ECR-008 study group.

更新日期：2019-03-28 00:00:00

abstract：:Human papillomavirus type 16 (HPV16)-transformed mouse TC-1 cells are extensively used in the evaluation of efficacy of experimental vaccines against tumours induced by HPVs. As these cells strongly express MHC class I molecules and downregulation of MHC class I surface expression is one of the important mechanisms th...

journal_title：Vaccine

authors： Smahel M,Síma P,Ludvíková V,Marinov I,Pokorná D,Vonka V

更新日期：2003-03-07 00:00:00

abstract：:Antibodies have the potential to be therapeutic reagents for malaria. Here we describe the production of a novel phage antibody display library against the C-terminal 19kDa region of the Plasmodium yoelii YM merozoite surface protein-1 (MSP1(19)). In vivo studies against homologous lethal malaria challenge show an ant...

journal_title：Vaccine

authors： Vukovic P,Chen K,Qin Liu X,Foley M,Boyd A,Kaslow D,Good MF

更新日期：2002-06-21 00:00:00

abstract：:For humoral immunization, it may be possible to make effective and safe peptide vaccines for various diseases by selection of proper B-cell epitopes. However, a lack of T-cell epitopes on short peptides, such as those associated with major histocompatibility complex (MHC)-restriction, is a major problem for peptide va...

journal_title：Vaccine

authors： Yano A,Onozuka A,Asahi-Ozaki Y,Imai S,Hanada N,Miwa Y,Nisizawa T

更新日期：2005-03-18 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired diarrhea, also known as C. difficile associated diarrhea. The two major toxins, toxin A and toxin B are produced by most C. difficile bacteria, but some strains, such as BI/NAP1/027 isolates, produce a third toxin called binary toxin. The precise biologic...

journal_title：Vaccine

authors： Wang S,Rustandi RR,Lancaster C,Hong LG,Thiriot DS,Xie J,Secore S,Kristopeit A,Wang SC,Heinrichs JH

更新日期：2016-03-04 00:00:00

abstract：:Although the theoretical concern of genetic recombination has been raised related to the use of live attenuated flavivirus vaccines [Seligman, Gould, Lancet 2004;363:2073-5], it has little foundation [e.g., Monath TP, Kanesa-Thasan N, Guirakhoo F, Pugachev K, Almond J, Lang J, et al. Vaccine 2005;23:2956-8]. To invest...

journal_title：Vaccine

authors： Pugachev KV,Schwaiger J,Brown N,Zhang ZX,Catalan J,Mitchell FS,Ocran SW,Rumyantsev AA,Khromykh AA,Monath TP,Guirakhoo F

更新日期：2007-09-17 00:00:00

abstract：:A family of platyhelminth tegument-specific proteins comprising of one or two calcium ion binding EF-hand and a dynein light chain-like domain, termed tegumental proteins, are considered as candidates of vaccine. In this study, we cloned and characterized SjTP22.4, a novel membrane-anchored tegumental protein in Schis...

journal_title：Vaccine

authors： Zhang Z,Xu H,Gan W,Zeng S,Hu X

更新日期：2012-07-20 00:00:00

abstract：INTRODUCTION:Diarrhea is one of the leading causes of death in children under 5, and an estimated 39% of these deaths are attributable to rotavirus. Currently two live, oral rotavirus vaccines have been introduced on the market; however, the herd immunity effect associated with rotavirus vaccine has not yet been quanti...

journal_title：Vaccine

authors： Pollard SL,Malpica-Llanos T,Friberg IK,Fischer-Walker C,Ashraf S,Walker N

更新日期：2015-07-31 00:00:00

abstract：:We performed a genome-wide association study (GWAS) of antibody levels in a multi-ethnic group of 1071 healthy smallpox vaccine recipients. In Caucasians, the most prominent association was found with promoter SNP rs10489759 in the LOC647132 pseudogene on chromosome 1 (p=7.77×10(-8)). In African-Americans, we identifi...

journal_title：Vaccine

authors： Ovsyannikova IG,Kennedy RB,O'Byrne M,Jacobson RM,Pankratz VS,Poland GA

更新日期：2012-06-13 00:00:00

abstract：BACKGROUND:In 2008, China introduced live, attenuated hepatitis A vaccine (L-HepA, licensed in 1992) and inactivated hepatitis A vaccine (I-HepA, licensed in 2002) nationwide, and is currently the only country using L-HepA in routine immunization. We assessed seropositivity and its duration following vaccination, safet...

journal_title：Vaccine

authors： Xiaojin S,Rodewald LE,Guomin Z,Hui Z,Ning M,Fuzhen W,Zundong Y

更新日期：2020-12-14 00:00:00

abstract：:In a severe pandemic, rapid production and deployment of vaccines will potentially be critical in mitigating the impact on populations and essential services. We compared access to vaccines and timing of delivery relative to identification of A(H1N1)pdm09 and the geographic progression of the pandemic in the WHO Europ...

journal_title：Vaccine

authors： Jorgensen P,Wasley A,Mereckiene J,Cotter S,Weber JT,Brown CS

更新日期：2013-08-28 00:00:00

abstract：:Porcine circovirus type-2b (PCV2b) is the primary global causative agent of porcine circovirus-associated disease (PCVAD). In this study, we first constructed a novel chimeric virus (PCV1-2b) with the PCV2b capsid gene cloned into the backbone of non-pathogenic PCV1. A pathogenicity study conducted in caesarean-derive...

journal_title：Vaccine

authors： Beach NM,Ramamoorthy S,Opriessnig T,Wu SQ,Meng XJ

更新日期：2010-12-16 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of serious acute lower respiratory illness in infants and young children and a significant cause of disease burden in the elderly and immunocompromised. There are no licensed RSV vaccines to address this significant public health need. While advances in vaccin...

journal_title：Vaccine

authors： Roberts JN,Graham BS,Karron RA,Munoz FM,Falsey AR,Anderson LJ,Marshall V,Kim S,Beeler JA

更新日期：2016-09-22 00:00:00