An ingenious design for peptide vaccines.

abstract：:The Decade of Vaccines (DoV) initiative, launched in 2010, has as its mission "to extend, by 2020 and beyond, the full benefits of immunization to all people, regardless of where they are born, who they are, or where they live". Through their life-saving vaccines, the research-based vaccine companies represented by th...

journal_title：Vaccine

authors： Keith JA,Agostini Bigger L,Arthur PA,Maes E,Daems R

更新日期：2013-04-18 00:00:00

abstract：BACKGROUND:China is the most populous country in the world, with an annual birth cohort of approximately 16 million, requiring an average of 500 million vaccine doses administered annually. In China, over 30 domestic and less than 10 overseas vaccine manufacturers supply over 60 licensed vaccine products, representing ...

journal_title：Vaccine

authors： Guo B,Page A,Wang H,Taylor R,McIntyre P

更新日期：2013-01-11 00:00:00

abstract：:Prevention of lifestyle-related diseases and promotion of physical and mental well-being in adolescents require an understanding of how life situations place adolescents at risk. The most important risk factors for hepatitis B virus (HBV) infection are sexual activity with more than one partner and injecting drug use....

journal_title：Vaccine

authors： Meheus A

更新日期：2000-02-18 00:00:00

abstract：:We have covalently conjugated an N-terminus Plasmodium vivax apical membrane antigen-1 (AMA-1) peptide to functionalized carbon nanotubes (f-CNT). Immunological characterization of this molecular conjugate revealed that the immunogen-AMA-1 peptide was appropriately presented after being conjugated to CNTs as well as b...

journal_title：Vaccine

authors： Yandar N,Pastorin G,Prato M,Bianco A,Patarroyo ME,Lozano JM

更新日期：2008-10-29 00:00:00

abstract：:Since vaccination against human papillomavirus (HPV) became available, awareness of HPV has dramatically increased. Implementation of a vaccine program varies internationally yet no studies have explored the influence this has on the public's knowledge of HPV. The present study aimed to explore differences in awarenes...

journal_title：Vaccine

authors： Marlow LA,Zimet GD,McCaffery KJ,Ostini R,Waller J

更新日期：2013-01-21 00:00:00

abstract：:Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's Disease, a chronic granulomatous enteritis of ruminants. Recently, an association of MAP bacilli with Crohn's disease in humans has been proposed. Due to genetic similarities and serological cross-reactivity of the M. avium complex wit...

journal_title：Vaccine

authors： Sechi LA,Ahmed N,Felis GE,Duprè I,Cannas S,Fadda G,Bua A,Zanetti S

更新日期：2006-01-16 00:00:00

abstract：:Reconstituted influenza virus (A/PR/8 strain) envelopes (RIVE) and influenza virus (A/Sichuan/87 (H3N2) strain) surface antigens were entrapped in dehydration-rehydration vesicles (DRV liposomes) composed of egg phosphatidylcholine (PC) or distearoyl phosphatidylcholine (DSPC DRV) and equimolar (32 mumol) cholesterol....

journal_title：Vaccine

authors： Gregoriadis G,Tan L,Ben-Ahmeida ET,Jennings R

更新日期：1992-01-01 00:00:00

abstract：:Increases in global travel, trade and urbanisation are leading to greater incidence of zoonotic disease, and livestock are often a key link in the spread of disease to humans. As such, livestock vaccination strategies, as a part of broader biosecurity solutions, are critical to both animal and human health. Importantl...

journal_title：Vaccine

authors： Layton DS,Choudhary A,Bean AGD

更新日期：2017-10-20 00:00:00

abstract：:The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronega...

journal_title：Vaccine

authors： Givens MD,Riddell KP,Walz PH,Rhoades J,Harland R,Zhang Y,Galik PK,Brodersen BW,Cochran AM,Brock KV,Carson RL,Stringfellow DA

更新日期：2007-01-15 00:00:00

abstract：:Optimal protection against malaria may require induction of high levels of protective antibody and CD8(+) and CD4(+) T cell responses. In humans, malaria DNA vaccines elicit CD8(+) cytotoxic T cells (CTL) and IFNgamma responses as measured by short-term (ex vivo) ELISPOT assays, and recombinant proteins elicit antibod...

journal_title：Vaccine

authors： Epstein JE,Charoenvit Y,Kester KE,Wang R,Newcomer R,Fitzpatrick S,Richie TL,Tornieporth N,Heppner DG,Ockenhouse C,Majam V,Holland C,Abot E,Ganeshan H,Berzins M,Jones T,Freydberg CN,Ng J,Norman J,Carucci DJ,Cohen J

更新日期：2004-04-16 00:00:00

abstract：:Humoral immunity against tick-borne encephalitis virus (TBEV) in patients with a well-documented history of naturally acquired tick-borne encephalitis (TBE) was compared with immunity resulting from vaccination in a carefully controlled immunization programme. The vaccination study was performed with a highly purified...

journal_title：Vaccine

authors： Klockmann U,Bock HL,Kwasny H,Praus M,Cihlová V,Tomková E,Krivanec K

更新日期：1991-01-01 00:00:00

abstract：:Measles transmission has been well documented in healthcare facilities. Healthcare personnel who are unvaccinated and who lack other evidence of measles immunity put themselves and their patients at risk for measles. We conducted a systematic literature review of measles vaccination policies and their implementation i...

journal_title：Vaccine

authors： Fiebelkorn AP,Seward JF,Orenstein WA

更新日期：2014-08-27 00:00:00

abstract：:Carbopol is a polyanionic carbomer gel used in man for a variety of topical applications and drug delivery purposes. Here we show that subcutaneous administration of carbopol with glycoprotein antigens elicits unusually strong specific adaptive immune responses in mice. Recombinant soluble HIV-1 envelope glycoprotein ...

journal_title：Vaccine

authors： Krashias G,Simon AK,Wegmann F,Kok WL,Ho LP,Stevens D,Skehel J,Heeney JL,Moghaddam AE,Sattentau QJ

更新日期：2010-03-16 00:00:00

abstract：:In recent years, collaborations often between mathematical and computational biologists and scientists in the World Health Organization (WHO) global influenza surveillance network, have resulted in a number of mathematical and computational advances including: increasing the resolution at which antigenic surveillance ...

journal_title：Vaccine

authors： Smith DJ

更新日期：2003-05-01 00:00:00

abstract：:This study investigated the immune response and safety in 430 adults, when boosted more than 3 years after primary or booster TBE immunisation as measured by neutralization test (NT) and ELISA. Tested by NT, the post-booster day 21 geometric mean titer (GMT) was 331 and 142 for the 18-49 and > or =50 years old, respec...

journal_title：Vaccine

authors： Rendi-Wagner P,Kundi M,Zent O,Banzhoff A,Jaehnig P,Stemberger R,Dvorak G,Grumbeck E,Laaber B,Kollaritsch H

更新日期：2004-12-09 00:00:00

abstract：:Since inactivated influenza vaccines mainly confer protective immunity by inducing strain-specific antibodies to the viral hemagglutinin, these vaccines only afford protection against infection with antigenically matching influenza virus strains. Due to the continuous emergence of antigenic drift variants of seasonal ...

journal_title：Vaccine

authors： Altenburg AF,Rimmelzwaan GF,de Vries RD

更新日期：2015-01-15 00:00:00

abstract：:Previously, we showed that intracutaneous vaccination of rabbits with DNA vectors encoding ubiquitin-fused versions of the cottontail rabbit papillomavirus (CRPV) early proteins E1, E2, E6 and E7 protected against subsequent challenge with CRPV. Here, we tested the immunotherapeutic activity of a vaccine composed of t...

journal_title：Vaccine

authors： Brandsma JL,Shlyankevich M,Zelterman D,Su Y

更新日期：2007-08-14 00:00:00

abstract：:Promotional campaigns recommend immunisation against influenza in healthcare workers (HCWs) but the uptake in this group remains low. We conducted a survey study during the 2008-2009 influenza vaccination period amongst future HCWs to quantify uptake and identify barriers to immunisation. Overall uptake was 8.0% (95% ...

journal_title：Vaccine

authors： Blank DL,Bodansky DM,Forbes A,Garde E,Story F,Roalfe AK,Tait L

更新日期：2010-06-23 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus nucleocapsid protein (SARS-CoV N) is one of the major targets for SARS vaccine due to its high potency in triggering immune responses. In this study, we have identified a novel HLA-A*0201 restricted epitope, N220 (LALLLLDRL), of the SARS-CoV N-protein through bioinform...

journal_title：Vaccine

authors： Cheung YK,Cheng SC,Sin FW,Chan KT,Xie Y

更新日期：2007-08-10 00:00:00

abstract：:We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with the injection and the attitude of parents concerning these events. A total of 505 ...

journal_title：Vaccine

authors： Halperin SA,Scheifele D,Mills E,Guasparini R,Humphreys G,Barreto L,Smith B

更新日期：2003-06-02 00:00:00

abstract：:Measles is one of the most important diseases of mankind, which is so highly contagious and evokes such persistent immunity that the virus cannot be sustained in a population of less than about 500,000 persons. The first of the licensed live virus vaccines against measles was developed empirically and was approved in ...

journal_title：Vaccine

authors： Hilleman MR

更新日期：2001-12-12 00:00:00

abstract：:The global health community is beginning to gain an understanding of the global burden of norovirus-associated disease, which appears to have significant burden in both developed- and developing-country populations. Of particular importance is the growing recognition of norovirus as a leading cause of gastroenteritis ...

journal_title：Vaccine

authors： Riddle MS,Walker RI

更新日期：2016-06-03 00:00:00

abstract：:Two cyclic peptide analogues corresponding to residues 139-146 (site A) of influenza A virus haemagglutinin (strain X31) were synthesized. The ability of these peptides to react with anti-influenza virus antibodies was found to depend on the conformation of the loop and on the orientation in which the peptide was pres...

journal_title：Vaccine

authors： Muller S,Plaué S,Samama JP,Valette M,Briand JP,Van Regenmortel MH

更新日期：1990-08-01 00:00:00

abstract：INTRODUCTION:The World Health Organization (WHO) recommends vaccination of health workers against influenza, but uptake in low-resource settings remains low. To complement routine global data collection efforts we conducted a detailed survey on influenza vaccination policies for health workers in low-income and middle-...

journal_title：Vaccine

authors： Maltezou HC,Theodoridou K,Tseroni M,Raftopoulos V,Bolster A,Kraigsley A,Bresee J,Lambach P

更新日期：2020-11-03 00:00:00

abstract：:In 2017, the World Health Organization (WHO) published a document aimed at facilitating influenza vaccine introduction and use in low- and middle-income countries. The document "The Immunological Basis for Immunization Series: Influenza Vaccines" is freely available on the WHO website. The main purpose of this documen...

journal_title：Vaccine

authors： Ortiz JR,Hombach J

更新日期：2018-09-05 00:00:00

abstract：INTRODUCTION:In recent years, vaccine preventable diseases such as measles and pertussis have been re-emerging in Western countries, maybe because of decreasing participation in childhood vaccination programs in some countries. There is clear evidence for vaccine efficacy and the risk of adverse effects is low. This ne...

journal_title：Vaccine

authors： Óskarsson Ý,Guðnason Þ,Jónsdóttir GA,Kristinsson KG,Briem H,Haraldsson Á

更新日期：2015-12-16 00:00:00

abstract：:Foot and Mouth Disease (FMD) is an acute disease caused by Foot and Mouth Disease Virus (FMDV) which causes important economy losses, this is why it is necessary to obtain a vaccine that stimulates a rapid and long-lasting protective immune response. Cliptox is a mineral microparticle that in earlier studies has shown...

journal_title：Vaccine

authors： Batista A,Quattrocchi V,Olivera V,Langellotti C,Pappalardo JS,Di Giacomo S,Mongini C,Portuondo D,Zamorano P

更新日期：2010-08-31 00:00:00

abstract：:Despite the extensive use of efficacious pertussis vaccines, Bordetella pertussis infections are still among the main causes for childhood morbidity and mortality. Severe pertussis occurs mostly in very young children, often too young to be sufficiently protected by current vaccines, which require several administrati...

journal_title：Vaccine

authors： Feunou PF,Ismaili J,Debrie AS,Huot L,Hot D,Raze D,Lemoine Y,Locht C

更新日期：2008-10-23 00:00:00

abstract：:Tuberculosis (TB) is the biggest cause of human mortality from an infectious disease. The only vaccine currently available, bacille Calmette-Guérin (BCG), demonstrates some protection against disseminated disease in childhood but very variable efficacy against pulmonary disease in adults. A greater understanding of pr...

journal_title：Vaccine

authors： Bull NC,Kaveh DA,Garcia-Pelayo MC,Stylianou E,McShane H,Hogarth PJ

更新日期：2018-09-05 00:00:00

abstract：:On 1 February 2016, in the context of the ongoing Zika virus epidemic, the WHO declared that the recently reported clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern (PHEIC). In response, WHO in collaboration with UNICEF and a working group of indep...

journal_title：Vaccine

authors： Vannice KS,Giersing BK,Kaslow DC,Griffiths E,Meyer H,Barrett A,Durbin AP,Wood D,Hombach J

更新日期：2019-11-28 00:00:00