Therapeutic vaccination of rabbits with a ubiquitin-fused papillomavirus E1, E2, E6 and E7 DNA vaccine.

abstract：:A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...

journal_title：Vaccine

authors： Edmunds WJ,Brisson M,Melegaro A,Gay NJ

更新日期：2002-01-31 00:00:00

abstract：:Leishmania donovani promastigote soluble antigens (sLAg) were encapsulated in non-phosphatidylcholine (non-PC) liposomes (escheriosomes) prepared from E. coli lipids. The escheriosome-based vaccine was investigated for its potential to elicit a protective immune response against experimental visceral leishmaniasis. Th...

journal_title：Vaccine

authors： Sharma SK,Dube A,Nadeem A,Khan S,Saleem I,Garg R,Mohammad O

更新日期：2006-03-10 00:00:00

abstract：:We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...

journal_title：Vaccine

authors： Mendelson I,Gat O,Aloni-Grinstein R,Altboum Z,Inbar I,Kronman C,Bar-Haim E,Cohen S,Velan B,Shafferman A

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:We performed a pooled analysis of randomised clinical trials (RCT) on HPV vaccine efficacy in preventing cervical persistent infection. METHODS:We carried out a bibliographic search on electronic databases and we selected RCT to perform the meta-analyses. RESULTS:We selected five studies. The first meta-...

journal_title：Vaccine

authors： La Torre G,de Waure C,Chiaradia G,Mannocci A,Ricciardi W

更新日期：2007-12-05 00:00:00

abstract：:Vaccine effects of in vivo gene-vaccinated skin graft were evaluated against Toxoplasma gondii (T. gondii) infection. By using a gene gun, cDNA coding T. gondii SAG1 molecule was intracutaneously vaccinated into C57BL/6 (B6; a susceptible strain), BALB/c (a resistant strain) and (C57BL/6 x BALB/c) F1 (CBF1) mice, and ...

journal_title：Vaccine

authors： Saito S,Aosai F,Rikihisa N,Mun HS,Norose K,Chen M,Kuroki T,Asano T,Ochiai T,Hata H,Ichinose M,Yano A

更新日期：2001-02-28 00:00:00

abstract：:We exploited the powerful adjuvant properties of cholera holotoxin (CT) to create a mucosally administered subunit vaccine against respiratory syncytial virus (RSV). A genetically detoxified mutant CT with an E to H substitution at amino acid 29 of the CT-A1 subunit (CT-E29H) was compared to wild type CT for toxicity ...

journal_title：Vaccine

authors： Tebbey PW,Scheuer CA,Peek JA,Zhu D,LaPierre NA,Green BA,Phillips ED,Ibraghimov AR,Eldridge JH,Hancock GE

更新日期：2000-06-01 00:00:00

abstract：:The objectives of this study were to evaluate the effects of a therapeutic vaccine intervention with a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine on the dynamics of a heterologous viral infection in a population of pigs, and to determine the clinical and virological response of p...

journal_title：Vaccine

authors： Cano JP,Dee SA,Murtaugh MP,Pijoan C

更新日期：2007-05-30 00:00:00

abstract：:Vaccine exposure to temperatures below recommended ranges in the cold chain may decrease vaccine potency of freeze-sensitive vaccines leading to a loss of vaccine investments and potentially places children at risk of contracting vaccine preventable illnesses. This literature review is an update to one previously publ...

journal_title：Vaccine

authors： Hanson CM,George AM,Sawadogo A,Schreiber B

更新日期：2017-04-19 00:00:00

abstract：:The toxicity of Clostridium difficile large clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations. However, a TcdB mutant with five point mutations (referred to herein as mTcdB) still has residual toxicity that can be detected in cell-based assays and in-viv...

journal_title：Vaccine

authors： Wang B,Wang S,Rustandi RR,Wang F,Mensch CD,Hong L,Kristopeit A,Secore S,Dornadula G,Kanavage A,Heinrichs JH,Mach H,Blue JT,Thiriot DS

更新日期：2015-01-01 00:00:00

abstract：:Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case-control design in Navarre, Spain. We included children 3-59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and...

journal_title：Vaccine

authors： Castilla J,Beristain X,Martínez-Artola V,Navascués A,García Cenoz M,Alvarez N,Polo I,Mazón A,Gil-Setas A,Barricarte A

更新日期：2012-01-11 00:00:00

abstract：BACKGROUND:Since 2006, two rotavirus vaccines have been licensed in Taiwan, either as a 2- (RV1) or 3-dose (RV5) schedule administered at ages 2, 4, and 6 months. This study assessed the risk of intussusception and Kawasaki disease (KD) associated with rotavirus vaccines among infants. METHODS:Cases of intussusception...

journal_title：Vaccine

authors： Huang WT,Juan YC,Liu CH,Yang YY,Chan KA

更新日期：2020-09-11 00:00:00

abstract：:A vaccine against the gonadotrophin-releasing hormone (GnRH) is being developed as an immunological method for treatment of prostatic hypertrophy, based on the observation that active immunization against GnRH leads to the production of anti-GnRH antibodies which results in the shrinkage of the prostate gland. We have...

journal_title：Vaccine

authors： Sad S,Chauhan VS,Arunan K,Raghupathy R

更新日期：1993-01-01 00:00:00

abstract：METHODS AND OBJECTIVES:To estimate the infant vaccination coverage in Belgium, a random cluster sample according to the expanded program on immunization (EPI) cluster sampling technique was performed in 1999 in the Flemish (Flanders) and French (Wallonia) speaking community of Belgium. The objective was to document the...

journal_title：Vaccine

authors： Swennen B,Van Damme P,Vellinga A,Coppieters Y,Depoorter AM

更新日期：2001-10-15 00:00:00

abstract：:It has been hypothesized that antibody induced by Plasmodium falciparum circumsporozoite protein vaccine would be effective against endemic human malaria. In a malaria endemic region of Kenya, 76 volunteers, in 38 pairs sleeping adjacently, were immunized with subunit circumsporozoite protein Asn-Ala-Asn-Pro tetrapept...

journal_title：Vaccine

authors： Sherwood JA,Copeland RS,Taylor KA,Abok K,Oloo AJ,Were JB,Strickland GT,Gordon DM,Ballou WR,Bales JD Jr,Wirtz RA,Wittes J,Gross M,Que JU,Cryz SJ,Oster CN,Roberts CR,Sadoff JC

更新日期：1996-06-01 00:00:00

abstract：:Tuberculosis caused by Mycobacterium tuberculosis continues to be one of the major public health problems in the world. The eventual control of this disease will require the development of a safe and effective vaccine. One of the approaches receiving a great deal of attention recently is subunit vaccination. An effica...

journal_title：Vaccine

authors： Sable SB,Plikaytis BB,Shinnick TM

更新日期：2007-02-19 00:00:00

abstract：BACKGROUND:The burden of influenza is increasingly recognised in Africa. The WHO recommends introducing influenza vaccination to high-risk groups: pregnant women, children <5 years, and the elderly. The Gambia currently has no influenza vaccination policy, but the NASIMMUNE study, a clinical trial of intranasal live at...

journal_title：Vaccine

authors： Armitage EP,Camara J,Bah S,Forster AS,Clarke E,Kampmann B,de Silva TI

更新日期：2018-03-20 00:00:00

abstract：:Influenza is a zoonotic disease caused by a constantly varying RNA virus resulting in a need for continuous surveillance to update human vaccines. Our knowledge indicates that the intermittent pandemics of influenza originate from influenza viruses or gene segments from influenza viruses in lower animals and birds. Th...

journal_title：Vaccine

authors： Webster RG

更新日期：2002-05-15 00:00:00

abstract：:We created and produced a novel self-assembling nanoparticle platform for delivery of peptide epitopes that induces CD8(+) and CD4(+)T cells that are protective against Toxoplasma gondii infection. These self-assembling polypeptide nanoparticles (SAPNs) are composed of linear peptide (LP) monomers which contain two co...

journal_title：Vaccine

authors： El Bissati K,Zhou Y,Dasgupta D,Cobb D,Dubey JP,Burkhard P,Lanar DE,McLeod R

更新日期：2014-05-30 00:00:00

abstract：:In a phase I/II dose escalation study, varying volumes (0.1 ml, 0.5 ml, 1.0 ml and 2.0 ml) of 7-valent pneumococcal conjugate vaccine (PCV) (Prevnar or 0.5 ml of 23-valent pneumococcal polysaccharide vaccine (PPV) were administered to 220 adults 70 through 79 years of age previously vaccinated with 0.5 ml PPV at age 6...

journal_title：Vaccine

authors： Jackson LA,Neuzil KM,Whitney CG,Starkovich P,Dunstan M,Yu O,Nelson JC,Feikin DR,Shay DK,Baggs J,Carste B,Nahm MH,Carlone G

更新日期：2005-05-25 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of the monovalent rotavirus vaccine (RV1) to prevent rotavirus diarrhea admissions to emergency departments (ED) in Colombia. METHODS:A multicenter case-control study was carried out in six Colombian cities from 2011 to January, 2013. Cases were laboratory confirmed rotavirus diar...

journal_title：Vaccine

authors： Cotes-Cantillo K,Paternina-Caicedo A,Coronell-Rodríguez W,Alvis-Guzmán N,Parashar UD,Patel M,De la Hoz-Restrepo F

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:The Global Vaccine Action Plan highlights the need for immunisation programmes to have sustainable access to predictable funding. A good understanding of current and future funding needs, commitments, and gaps is required to enhance planning, improve resource allocation and mobilisation, and to avoid funding...

journal_title：Vaccine

authors： Guthrie T,Zikusooka C,Kwesiga B,Abewe C,Lagony S,Schutte C,Marinda E,Humphreys K,Motlogelwa K,Nombewu ZC,Brenzel L,Kinghorn A

更新日期：2015-05-07 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is the most common cause of bacterial diarrhea worldwide and is an important cause of infant morbidity and mortality in developing nations. ETEC colonization factors (CF) are virulence determinants that appear to be protective antigens in humans and are the major target of vacci...

journal_title：Vaccine

authors： de Lorimier AJ,Byrd W,Hall ER,Vaughan WM,Tang D,Roberts ZJ,McQueen CE,Cassels FJ

更新日期：2003-06-02 00:00:00

abstract：:We have recently shown that immunization against the extra domain-B (ED-B) of fibronectin, using Freund's adjuvant, reduces tumor growth in mice by 70%. In the present study we compare the immune response generated against ED-B using the non-toxic and biodegradable adjuvant Montanide ISA 720/CpG with the response elic...

journal_title：Vaccine

authors： Huijbers EJ,Femel J,Andersson K,Björkelund H,Hellman L,Olsson AK

更新日期：2012-01-05 00:00:00

abstract：:Respiratory syncytial virus causes a significant public health burden, particularly in very young infants and the frail elderly. The legacy of enhanced RSV disease (ERD) from a whole formalin-inactivated RSV vaccine, and the complex biology of the virus and the neonate have delayed the development of effective vaccine...

journal_title：Vaccine

authors： Graham BS

更新日期：2016-06-24 00:00:00

abstract：:There is accumulating evidence that many invertebrates including insects can acquire enhanced immune protection against subsequently pathogens infection through immune priming. However, whether the toxin protein from pathogenic bacteria can induce such priming response remains unclear. Here we cloned, expressed and pu...

journal_title：Vaccine

authors： Wu G,Yi Y,Sun J,Li M,Qiu L

更新日期：2015-11-17 00:00:00

abstract：:Prior to routine immunisation, Haemophilus influenzae serotype b (Hib) was a major cause of serious bacterial infections, particularly in young children. In the United Kingdom, introduction of the Hib conjugate vaccine into the national childhood immunisation schedule has led to a sustained decline in invasive Hib dis...

journal_title：Vaccine

authors： Townsend K,Ladhani SN,Findlow H,Borrow R

更新日期：2014-09-29 00:00:00

abstract：:Patients with malignancies are considered to be at increased risk of acquiring influenza. Because of higher complication and case fatality rates, preventive measures such as vaccination are of great interest. The objective of this study was to assess the acceptability, tolerability and immunogenicity of an adjuvant-fr...

journal_title：Vaccine

authors： Lagler H,Tobudic S,Ramharter M,Elandt K,Sperr WR,Redlberger-Fritz M,Popow-Kraupp T,Jäger U,Zielinski CC,Burgmann H

更新日期：2012-11-06 00:00:00

abstract：:The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternat...

journal_title：Vaccine

authors： Pyo HM,Masic A,Woldeab N,Embury-Hyatt C,Lin L,Shin YK,Song JY,Babiuk S,Zhou Y

更新日期：2012-02-08 00:00:00

abstract：:Immunization with Mycobacterium bovis Bacille Calmette-Guerin (BCG) did not induce adequate Th1 responses to the latency antigen, HspX of M. tuberculosis. To increase the immunogenicity and protective efficacy of BCG, a recombinant BCG strain over-expressing antigen HspX (rBCG::X) was constructed. The recombinant stra...

journal_title：Vaccine

authors： Shi C,Chen L,Chen Z,Zhang Y,Zhou Z,Lu J,Fu R,Wang C,Fang Z,Fan X

更新日期：2010-07-19 00:00:00

abstract：:Autovaccines are therapeutic vaccines manufactured from a disease causing micro-organism for individual treatment of patients, animals, or sometimes herds to treat chronic or recurrent infections. Despite the common use of autovaccines in veterinary medicine, their mechanism of action, i.e. the immunologic effector me...

journal_title：Vaccine

authors： Nolte O,Morscher J,Weiss HE,Sonntag H

更新日期：2001-04-30 00:00:00