当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.

Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.

Abstract：

:Optimal protection against malaria may require induction of high levels of protective antibody and CD8(+) and CD4(+) T cell responses. In humans, malaria DNA vaccines elicit CD8(+) cytotoxic T cells (CTL) and IFNgamma responses as measured by short-term (ex vivo) ELISPOT assays, and recombinant proteins elicit antibodies and excellent T cell responses, but no CD8(+) CTL or CD8(+) IFNgamma-producing cells as measured by ex vivo ELISPOT. Priming with DNA and boosting with recombinant pox virus elicits much better T cell responses than DNA alone, but not antibody responses. In an attempt to elicit antibodies and enhanced T cell responses, we administered RTS,S/AS02A, a partially protective Plasmodium falciparum recombinant circumsporozoite protein (CSP) vaccine in adjuvant, to volunteers previously immunized with a P. falciparum CSP DNA vaccine (VCL-2510) and to naïve volunteers. This vaccine regimen was well tolerated and safe. The volunteers who received RTS,S/AS02A alone had, as expected, antibody and CD4(+) T cell responses, but no CD8(+) T cell responses. Volunteers who received PfCSP DNA followed by RTS,S/AS02A had antibody and CD8(+) and CD4(+) T cell responses (Wang et al., submitted). Sequential immunization with DNA and recombinant protein, also called heterologous prime-boost, led to enhanced immune responses as compared to DNA or recombinant protein alone, suggesting that it might provide enhanced protective immunity.

journal_name

Vaccine

journal_title

Vaccine

authors

Epstein JE,Charoenvit Y,Kester KE,Wang R,Newcomer R,Fitzpatrick S,Richie TL,Tornieporth N,Heppner DG,Ockenhouse C,Majam V,Holland C,Abot E,Ganeshan H,Berzins M,Jones T,Freydberg CN,Ng J,Norman J,Carucci DJ,Cohen J

doi

10.1016/j.vaccine.2004.01.031

subject

Has Abstract

pub_date

2004-04-16 00:00:00

pages

1592-603

issue

13-14

eissn

0264-410X

issn

1873-2518

pii

S0264410X04000799

journal_volume

22

pub_type

临床试验,杂志文章

相关文献

VACCINE文献大全
  • Oral immunization of chickens with avirulent Salmonella vaccine strain carrying C. jejuni 72Dz/92 cjaA gene elicits specific humoral immune response associated with protection against challenge with wild-type Campylobacter.

    abstract：:It is well documented that poultry and poultry products are the major source of human campylobacteriosis and salmonellosis. This study examined the general efficacy of avirulent Salmonella vaccine strains expressing Campylobacter antigen as a bivalent chicken vaccine prototype. Three C. jejuni genes: cjaA (cj0982c), c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.11.001

    authors： Wyszyńska A,Raczko A,Lis M,Jagusztyn-Krynicka EK

    更新日期：2004-03-29 00:00:00

  • Genetic diversity and population dynamics of Bordetella pertussis in China between 1950-2007.

    abstract：:Pertussis is an acute respiratory infectious disease caused by the bacterium Bordetella pertussis. Although pertussis vaccination was introduced in the 1960s, pertussis is still an endemic disease in China. To better understand the genetic diversity of the Chinese B. pertussis population, we characterized 115 clinical...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.09.040

    authors： Xu Y,Zhang L,Tan Y,Wang L,Zhang S,Wang J

    更新日期：2015-11-17 00:00:00

  • A fish specific expression vector containing the interferon regulatory factor 1A (IRF1A) promoter for genetic immunization of fish.

    abstract：:DNA plasmid vectors were constructed with inducible rainbow trout promoters to take the place of the cytomegalovirus immediate early promoter in DNA vaccines for fish. DNA fragments containing the promoter regions upstream of the rainbow trout Mx1 and interferon regulatory factor 1A (IRF1A) genes were obtained and the...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00749-1

    authors： Alonso M,Johnson M,Simon B,Leong JA

    更新日期：2003-04-02 00:00:00

  • Preclinical development of a dengue tetravalent recombinant subunit vaccine: Immunogenicity and protective efficacy in nonhuman primates.

    abstract：:We describe here the preclinical development of a dengue vaccine composed of recombinant subunit carboxy-truncated envelope (E) proteins (DEN-80E) for each of the four dengue serotypes. Immunogenicity and protective efficacy studies in Rhesus monkeys were conducted to evaluate monovalent and tetravalent DEN-80E vaccin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.06.067

    authors： Govindarajan D,Meschino S,Guan L,Clements DE,ter Meulen JH,Casimiro DR,Coller BA,Bett AJ

    更新日期：2015-08-07 00:00:00

  • Protection against tick-borne encephalitis virus isolated in Japan by active and passive immunization.

    abstract：:In order to establish a firm preventive measure for tick-borne encephalitis (TBE) in Japan, we evaluated the immune response of European vaccine against Japanese TBE virus strain (Oshima 5-10) for man and mouse. Furthermore, the efficacy of pre- and post-exposure protection by a polyclonal rabbit anti-TBE virus serum ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00360-0

    authors： Chiba N,Osada M,Komoro K,Mizutani T,Kariwa H,Takashima I

    更新日期：1999-03-17 00:00:00

  • Immunogenicity of multivalent Shigella-ETEC candidate vaccine strains in a guinea pig model.

    abstract：:Shigella and enterotoxigenic Escherichia coli continue to be significant causes of diarrheal disease in infants and young children in developing countries as well as prevalent agents of traveler's diarrhea. A vaccine which provides protection against disease caused by both pathogens would serve common at-risk populati...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.07.013

    authors： Barry EM,Wang J,Wu T,Davis T,Levine MM

    更新日期：2006-05-01 00:00:00

  • Cost of plasma-derived hepatitis B vaccine production.

    abstract：:It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(90)90101-q

    authors： Mahoney RT

    更新日期：1990-08-01 00:00:00

  • Gene gun DNA vaccination with Rev-independent synthetic HIV-1 gp160 envelope gene using mammalian codons.

    abstract：:DNA immunization with HIV envelope plasmids induce only moderate levels of specific antibodies which may in part be due to limitations in expression influenced by a species-specific and biased HIV codon usage. We compared antibody levels, Th1/Th2 type and CTL responses induced by synthetic genes encoding membrane boun...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00474-5

    authors： Vinner L,Nielsen HV,Bryder K,Corbet S,Nielsen C,Fomsgaard A

    更新日期：1999-04-23 00:00:00

  • Antigenicity and immunogenicity of unique prefusion-mimic F proteins presented on enveloped virus-like particles.

    abstract：:Pre-fusion stabilizing mutations (DS-Cav1) in soluble fusion (F) proteins of human respiratory syncytial virus (RSV) were previously reported. Here we investigated the antigenic and immunogenic properties of pre-fusion like RSV F proteins on enveloped virus-like particles (VLP). Additional mutations were introduced to...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.09.041

    authors： Kwon YM,Lee Y,Kim KH,Jung YJ,Li Z,Jeeva S,Lee S,Moore ML,Kang SM

    更新日期：2019-10-16 00:00:00

  • Vaccinator device for delivering propellant-driven aerosols of Streptococcus suis bacterin into the respiratory tracts of swine.

    abstract：:Metered-dose propellant-driven small particle aerosols of a killed whole bacterium, Streptococcus suis, were produced and characterized for their aerodynamic particle sizes and antigenicity as potential respiratory mucosal vaccines against S. suis infections in swine. To facilitate the efficient delivery of such vacci...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00297-1

    authors： Brown AR,George DW,Matteson DK

    更新日期：1997-08-01 00:00:00

  • Immunisation with a plasmid DNA vaccine encoding gonadotrophin releasing hormone (GnRH-I) and T-helper epitopes in saline suppresses rodent fertility.

    abstract：:Research into active immunisation against gonadotrophin releasing hormone (GnRH-I) has gained widespread acceptance as a means of controlling reproduction and behaviour of farm, companion and wild animals. Many studies describe the use of multiple copies of the self-peptide in linear alignment and conjugation with a l...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.12.052

    authors： Khan MA,Ogita K,Ferro VA,Kumasawa K,Tsutsui T,Kimura T

    更新日期：2008-03-04 00:00:00

  • Immunogenic virus-like particles continuously expressed in mammalian cells as a veterinary rabies vaccine candidate.

    abstract：:Rabies is one of the most lethal infectious diseases in the world, with a mortality approaching 100%. There are between 60,000 and 70,000 reported annual deaths, but this is probably an underestimation. Despite the fact that there are vaccines available for rabies, there is a real need of developing more efficacious a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.03.088

    authors： Fontana D,Kratje R,Etcheverrigaray M,Prieto C

    更新日期：2015-08-20 00:00:00

  • An inactivated poliovirus vaccine using Sabin strains produced on the serum-free PER.C6® cell culture platform is immunogenic and safe in a non-human primate model.

    abstract：BACKGROUND:The World Health Organization recommends the development of affordable next-generation inactivated poliovirus vaccines (IPV) using attenuated poliovirus Sabin strains. Previously, we introduced a novel PER.C6® cell culture platform, which allows for high yield production of an affordable trivalent Sabin IPV ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.09.068

    authors： Bockstal V,Tiemessen MM,Achterberg R,Van Wordragen C,Knaapen AM,Serroyen J,Marissen WE,Schuitemaker H,Zahn R

    更新日期：2018-11-12 00:00:00

  • Pneumococcal vaccination in patients with systemic lupus erythematosus: A multicenter placebo-controlled randomized double-blind study.

    abstract：BACKGROUND:Invasive pneumococcal disease and respiratory tract infections are both frequent and severe in patients with systemic lupus erythematosus (SLE). This study aimed to compare the immunological efficacy and safety of pneumococcal vaccination with the 23-valent polysaccharide (PPS) vaccine alone to a sequential ...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2017.07.094

    authors： Grabar S,Groh M,Bahuaud M,Le Guern V,Costedoat-Chalumeau N,Mathian A,Hanslik T,Guillevin L,Batteux F,Launay O,VACCILUP study group.

    更新日期：2017-09-05 00:00:00

  • A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis.

    abstract：:Adult patients with mucosal leishmaniasis (ML) were enrolled in a randomized, double-blind, placebo-controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE vaccine (consisting of 5, 10, or 20 μg recombinant Leishmania polyprotein LEISH-F1 antigen+...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2010.08.092

    authors： Llanos-Cuentas A,Calderón W,Cruz M,Ashman JA,Alves FP,Coler RN,Bogatzki LY,Bertholet S,Laughlin EM,Kahn SJ,Beckmann AM,Cowgill KD,Reed SG,Piazza FM

    更新日期：2010-10-28 00:00:00

  • Synergistic action of cholera toxin B subunit (and Escherichia coli heat-labile toxin B subunit) and a trace amount of cholera whole toxin as an adjuvant for nasal influenza vaccine.

    abstract：:Cholera toxin B subunit (CTB) and Escherichia coli heat-labile toxin (LTB) (2 micrograms), each supplemented with a trace amount of cholera toxin (CT) (0.02-20 ng), were examined for the adjuvant effect on antibody (Ab) response against influenza inactivated HA (haemagglutinin) vaccine in Balb/c mice. Each mouse recei...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(94)90118-x

    authors： Tamura S,Yamanaka A,Shimohara M,Tomita T,Komase K,Tsuda Y,Suzuki Y,Nagamine T,Kawahara K,Danbara H

    更新日期：1994-04-01 00:00:00

  • Predictive value of seizure ICD-9 codes for vaccine safety research.

    abstract：:Post-licensure vaccine safety studies often monitor for seizures using automated screening of ICD-9 codes. This study assessed the positive predictive value (PPV) of ICD-9 codes used to identify seizure visits in children aged 6 weeks to 23 months who were enrolled in seven managed care organizations during January 20...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2009.06.092

    authors： Shui IM,Shi P,Dutta-Linn MM,Weintraub ES,Hambidge SJ,Nordin JD,Lieu TA,Vaccine Safety Datalink Research Team.

    更新日期：2009-08-27 00:00:00

  • Evaluation of protective immunity of Leptospira immunoglobulin like protein A (LigA) DNA vaccine against challenge in hamsters.

    abstract：:We demonstrated earlier that immunization with recombinant Leptospira immunoglobulin like protein A (LigA) induced significant protection against virulent Leptospira interrogans serovar Pomona challenge in hamsters. However, the protective immune mechanism remains unclear. In the present study we demonstrated the prot...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.10.029

    authors： Faisal SM,Yan W,Chen CS,Palaniappan RU,McDonough SP,Chang YF

    更新日期：2008-01-10 00:00:00

  • Management of acute and fulminant hepatitis A.

    abstract：:Symptomatic viral hepatitis A usually only requires supportive therapy and the majority of cases are managed in the community. The prodromal symptoms of nausea, anorexia and lethargy tend to improve with the onset of clinical jaundice. Fulminant hepatic failure is said to be an uncommon complication, occurring in only...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/0264-410x(92)90535-r

    authors： O'Grady J

    更新日期：1992-01-01 00:00:00

  • Decline of varicella vaccination in German surveillance regions after recommendation of separate first-dose vaccination for varicella and measles-mumps-rubella.

    abstract：BACKGROUND:Germany introduced routine varicella (V) vaccination in 2004. Due to a slightly increased risk of febrile convulsions after first-dose application of combined measles-mumps-rubella-varicella (MMRV) vaccine separate first-dose vaccinations with MMR and monovalent V vaccine were recommended in September 2011. ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.12.065

    authors： Streng A,Liese JG

    更新日期：2014-02-12 00:00:00

  • Use of o-phthalaldehyde assay to determine protein contents of Alhydrogel-based vaccines.

    abstract：:Aluminum based adjuvants (alum), including aluminum hydroxide (Alhydrogel) and aluminum phosphate are the most commonly used adjuvant in the US. In order to ensure quality of vaccines, regulatory authorities require evaluation of antigen content in final vaccine products. Currently, there are no generic methods availa...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.07.067

    authors： Zhu D,Saul A,Huang S,Martin LB,Miller LH,Rausch KM

    更新日期：2009-10-09 00:00:00

  • New neutralizing antibody epitopes in hepatitis C virus envelope glycoproteins are revealed by dissecting peptide recognition profiles.

    abstract：:One of the greatest challenges to HCV vaccine development is the induction of effective immune responses using recombinant proteins or vectors. In order to better understand which vaccine-induced antibodies contribute to neutralization of HCV the quality of polyclonal anti-E1E2 antibody responses in immunized mice and...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.10.045

    authors： Kachko A,Kochneva G,Sivolobova G,Grazhdantseva A,Lupan T,Zubkova I,Wells F,Merchlinsky M,Williams O,Watanabe H,Ivanova A,Shvalov A,Loktev V,Netesov S,Major ME

    更新日期：2011-12-09 00:00:00

  • South Asia symposium on pneumococcal disease and the promise of vaccines - Meeting report.

    abstract：:Despite the licensure of the pneumococcal conjugate vaccine (PCV) in the US and other Western countries for over 14 years, as of September 2014 only 4 South Asian countries were using PCV in their universal immunization program. To generate momentum toward addressing this issue a "South Asia symposium on pneumococcal ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.03.071

    authors： Kumar R,Arora N,Santosham M

    更新日期：2016-05-17 00:00:00

  • Flagellin enhances the immunoprotection of formalin-inactivated Edwardsiella tarda vaccine in turbot.

    abstract：:Edwardsiella tarda is an important fish pathogen that causes extensive losses in farmed fish around the world. Various types of vaccines have been developed against E. tarda infection, such as inactivated vaccine, live attenuated vaccine and subunit vaccine. However, inactivated vaccine exhibits poor immune protection...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.11.031

    authors： Liu X,Zhang H,Jiao C,Liu Q,Zhang Y,Xiao J

    更新日期：2017-01-05 00:00:00

  • Safety and immunogenicity of a DTaP-IPV(Vero) (serum-free) combination vaccine in comparison to DTaP-IPV(Mkc) when administered simultaneously with Haemophilus influenzae type B conjugate vaccine (PRP-T) in children at 2, 3.5, 5 and 16 months of age.

    abstract：:In a phase III, double blind, randomized, noninferiority, multi-centre clinical trial, 817 infants were included and randomly assigned to vaccination with DTaP-IPV(Vero) (N=410) or DTaP-IPV(Mkc) (N=407) vaccines (Statens Serum Institut (SSI), Denmark) in the right thigh. All infants were vaccinated with Act-HIB (Sanof...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2008.07.033

    authors： Pietrzyk JJ,Wysocki J,Pejcz J,Galaj A,Majda-Stanislawska E,Käyhty H,Thierry-Carstensen B,Jensen AM

    更新日期：2008-09-26 00:00:00

  • A randomized, double-blind, controlled clinical trial to evaluate the safety and immunogenicity of an intranasally administered trivalent inactivated influenza vaccine with adjuvant LTh(αK): A phase I study.

    abstract：BACKGROUND:A nasal influenza vaccine has been available only in a live attenuated form, which limits the range of recipients to immune-competent individuals. The present study evaluated a newly developed intranasal inactivated influenza vaccine with a novel adjuvant, heat-labile enterotoxin (LT) derived from E. coli (L...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2019.02.006

    authors： Pan SC,Hsieh SM,Lin CF,Hsu YS,Chang M,Chang SC

    更新日期：2019-03-28 00:00:00

  • Willingness to participate in Ebola viral disease vaccine trials and receive vaccination by health workers in a tertiary hospital in Ile-Ife, Southwest Nigeria.

    abstract：BACKGROUND:Ebola viral disease (EVD) epidemic need to be contained through means which include vaccination of susceptible population. Vaccination has eradicated major killer diseases. OBJECTIVE:The study determined the health workers willingness to participate in EVD vaccine clinical trials and receive EVD vaccine. M...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.10.004

    authors： Olowookere SA,Abioye-Kuteyi EA,Adekanle O

    更新日期：2016-11-11 00:00:00

  • Vaccine hesitancy towards childhood immunisation amongst urban pregnant mothers in Malaysia.

    abstract：BACKGROUND:Vaccine hesitancy is a complex behaviour which involves various degrees of indecision about specific vaccines or vaccination uptake. Access to antenatal care had been associated with positive vaccine behavior. OBJECTIVE:To determine the prevalence of vaccine hesitancy towards childhood immunisation amongst ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.01.043

    authors： Kalok A,Loh SYE,Chew KT,Abdul Aziz NH,Shah SA,Ahmad S,Mohamed Ismail NA,Abdullah Mahdy Z

    更新日期：2020-02-24 00:00:00

  • Expanding immunization coverage in rural India: a review of evidence for the role of community health workers.

    abstract：:Poor routine immunization coverage in India has led to a large burden of vaccine-preventable diseases borne by children under 5 years of age. Despite efforts to strengthen infrastructure and service delivery in the past decade, immunization coverage rates have reached a plateau. To meet the formidable needs of India's...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2009.10.108

    authors： Patel AR,Nowalk MP

    更新日期：2010-01-08 00:00:00

  • A dose-escalation safety and immunogenicity study of a new live attenuated human rotavirus vaccine (Rotavin-M1) in Vietnamese children.

    abstract：:We tested a candidate live, oral, rotavirus vaccine (Rotavin-M1™) derived from an attenuated G1P [8] strain (KH0118-2003) isolated from a child in Vietnam. The vaccine was tested first for safety in 29 healthy adults. When deemed safe, it was further tested for safety and immunogenicity in 160 infants (4 groups) aged ...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2011.07.118

    authors： Dang DA,Nguyen VT,Vu DT,Nguyen TH,Nguyen DM,Yuhuan W,Baoming J,Nguyen DH,Le TL,Rotavin-M1 Vaccine Trial Group.

    更新日期：2012-04-27 00:00:00