Abstract：
:Two cyclic peptide analogues corresponding to residues 139-146 (site A) of influenza A virus haemagglutinin (strain X31) were synthesized. The ability of these peptides to react with anti-influenza virus antibodies was found to depend on the conformation of the loop and on the orientation in which the peptide was presented to antibodies. Antibodies raised to the peptides were able to bind in ELISA with influenza virus antigen that had been allowed to dry on the microtitre plate. When OF1 mice were immunized with cyclic peptides, approximately 80% of the animals were protected against an intranasal challenge with influenza virus.
journal_name
Vaccinejournal_title
Vaccineauthors
Muller S,Plaué S,Samama JP,Valette M,Briand JP,Van Regenmortel MHdoi
10.1016/0264-410x(90)90086-2subject
Has Abstractpub_date
1990-08-01 00:00:00pages
308-14issue
4eissn
0264-410Xissn
1873-2518pii
0264-410X(90)90086-2journal_volume
8pub_type
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