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Development of lactococcal GEM-based pneumococcal vaccines.

Abstract：

:We report the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed Lactococcus lactis-derived delivery system, called Gram-positive Enhancer Matrix (GEM). The GEM particles induced the production of the proinflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) by macrophages as well as the maturation of dendritic cells. The pneumococcal proteins IgA1 protease (IgA1p), putative proteinase maturation protein A (PpmA) and streptococcal lipoprotein A (SlrA) were anchored in trans to the surface of the GEM particles after recombinant production of the antigens in L. lactis as hybrids with a lactococcal cell wall binding domain, named Protein Anchor domain (PA). Intranasal immunisation with the SlrA-IgA1p or trivalent vaccine combinations without additional adjuvants showed significant protection against fatal pneumococcal pneumonia in mice. The GEM-based trivalent vaccine is a potential pneumococcal vaccine candidate that is expected to be easy to administer, safe and affordable to produce.

journal_name

Vaccine

journal_title

Vaccine

authors

Audouy SA,van Selm S,van Roosmalen ML,Post E,Kanninga R,Neef J,Estevão S,Nieuwenhuis EE,Adrian PV,Leenhouts K,Hermans PW

doi

10.1016/j.vaccine.2006.09.026

subject

Has Abstract

pub_date

2007-03-22 00:00:00

pages

2497-506

issue

13

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)01028-0

journal_volume

25

pub_type

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