Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide.


:Staphylococci have become the most common causes of nosocomial bacterial infections, and this fact, along with increasing problems associated with antimicrobial resistance, spurs the need for finding immunotherapeutic alternatives to prevent and possibly treat these infections. Most virulent, clinical isolates of both coagulase-negative staphylococci (CoNS) and Staphylococcus aureus carry the ica locus which encodes proteins that synthesize a polymer of beta-1-6 linked N-acetyl glucosamine residues (PNAG). Animal studies have shown purified PNAG can elicit protective immunity against both CoNS and S. aureus, suggesting its potential as a broadly protective vaccine for many clinically important strains of staphylococci.






Maira-Litran T,Kropec A,Goldmann D,Pier GB




Has Abstract


2004-02-17 00:00:00
















  • Measles vaccine adverse events reported in the mass vaccination campaign of Sichuan province, China from 2007 to 2008.

    abstract::The aim of this study was to characterize the adverse events of attenuated measles vaccine in mainland China. We carried out prospective follow-up of adverse events after mass measles immunization practices, categorizing them into two groups: allergic reactions and serious adverse events. The incidence of anaphylaxis ...


    pub_type: 杂志文章


    authors: Shu M,Liu Q,Wang J,Ao R,Yang C,Fang G,Wan C,Guo W

    更新日期:2011-04-18 00:00:00

  • Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine.

    abstract::There is a substantial need to develop better influenza virus vaccines that can protect populations that are not adequately protected by the currently licensed vaccines. While live attenuated influenza virus vaccines induce superior immune responses compared to inactivated vaccines, the manufacturing process of both t...


    pub_type: 杂志文章


    authors: Kopecky-Bromberg SA,Fraser KA,Pica N,Carnero E,Moran TM,Franck RW,Tsuji M,Palese P

    更新日期:2009-06-08 00:00:00

  • Estimating the effect of measles vaccination on child growth using 191 DHS from 65 low- and middle-income countries.

    abstract:BACKGROUND:Childhood vaccinations reduce morbidity and mortality and are highly cost-effective. They may also protect children from malnutrition and lead to improved child growth. Stunting, wasting and underweight are targets used to monitor progress towards the achievement of the sustainable development goals (SDGs). ...


    pub_type: 杂志文章


    authors: Bogler L,Jantos N,Bärnighausen T,Vollmer S

    更新日期:2019-08-14 00:00:00

  • Liposomes enhance the immunogenicity of reconstituted influenza virus A/PR/8 envelopes and the formation of protective antibody by influenza virus A/Sichuan/87 (H3N2) surface antigen.

    abstract::Reconstituted influenza virus (A/PR/8 strain) envelopes (RIVE) and influenza virus (A/Sichuan/87 (H3N2) strain) surface antigens were entrapped in dehydration-rehydration vesicles (DRV liposomes) composed of egg phosphatidylcholine (PC) or distearoyl phosphatidylcholine (DSPC DRV) and equimolar (32 mumol) cholesterol....


    pub_type: 杂志文章


    authors: Gregoriadis G,Tan L,Ben-Ahmeida ET,Jennings R

    更新日期:1992-01-01 00:00:00

  • Influenza antigen-sparing by immune stimulation with Gram-positive enhancer matrix (GEM) particles.

    abstract::Gram-positive enhancer matrix (GEM) particles, produced from non-genetically modified Lactococcus lactis bacteria have an inherent immunostimulatory activity. It was investigated whether co-administration of GEM particles can reduce the amount of influenza subunit vaccine (HA) necessary to protect mice from viral infe...


    pub_type: 杂志文章


    authors: Saluja V,Visser MR,Ter Veer W,van Roosmalen ML,Leenhouts K,Hinrichs WL,Huckriede A,Frijlink HW

    更新日期:2010-11-23 00:00:00

  • Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity.

    abstract::By using a baculovirus expression system, we have successfully produced simian immunodeficiency virus (SIV)-like particles (VLPs) with high levels of biologically active SIV envelope (Env) incorporated on their surfaces. To study whether SIV VLPs represent effective mucosal immunogens, we immunized groups of mice with...


    pub_type: 杂志文章


    authors: Yao Q,Vuong V,Li M,Compans RW

    更新日期:2002-06-07 00:00:00

  • Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults.

    abstract::The safety, reactogenicity and immunogenicity of three candidate Lyme vaccines based on recombinant outer surface protein (OspA) presented in either lipidated or unlipidated forms, were assessed in 300 seronegative volunteers. Subjects received three doses of one of the three formulations at monthly intervals and were...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Van Hoecke C,Comberbach M,De Grave D,Desmons P,Fu D,Hauser P,Lebacq E,Lobet Y,Voet P

    更新日期:1996-12-01 00:00:00

  • Cross-reactive neutralizing antibody epitopes against Enterovirus 71 identified by an in silico approach.

    abstract::Currently, infections of hand, foot and mouth disease (HFMD) due to Human Enterovirus 71 (EV71) cannot be prevented or treated, as there are no suitable vaccines or antiviral drugs. This study aimed to identify potential vaccine candidates for EV71 using in silico analysis of its viral capsid proteins. A combined in s...


    pub_type: 杂志文章


    authors: Kirk K,Poh CL,Fecondo J,Pourianfar H,Shaw J,Grollo L

    更新日期:2012-11-19 00:00:00

  • Repeated dose intramuscular injection of the CIMAvax-EGF vaccine in Sprague Dawley rats induces local and systemic toxicity.

    abstract::CIMAvax-EGF consists of a human recombinant epidermal growth factor (EGF), coupled to P64k, a recombinant carrier protein from N. meningitis, and Montanide ISA 51 as adjuvant. The vaccine immunization induces a specific antibody production, inhibiting the EGF/EGF-R interaction through EGF deprivation. The objective of...


    pub_type: 杂志文章


    authors: Mancebo A,Casacó A,González B,Ledón N,Sorlozabal J,León A,Gómez D,González Y,Bada AM,González C,Arteaga ME,Ramírez H,Fuentes D

    更新日期:2012-05-09 00:00:00

  • A novel peptide isolated from phage library to substitute a complex system for a vaccine against staphylococci infection.

    abstract::Staphylococcus aureus is a major human pathogen and many of the strains are resistant to conventional antibacterial treatment. The bacteria cause disease largely due to the production of multiple toxins, whose synthesis is controlled by an RNA molecule termed RNAIII. The production of RNAIII is induced by quorum sensi...


    pub_type: 杂志文章


    authors: Yang G,Gao Y,Dong J,Xue Y,Fan M,Shen B,Liu C,Shao N

    更新日期:2006-02-20 00:00:00

  • Factors influencing frontline health service providers' likelihood to recommend a future, preventive HIV vaccine to key populations in Karnataka, south India.

    abstract::The HIV epidemic in the south Indian state of Karnataka disproportionately burdens key populations of men who have sex with men and female sex workers. Despite having successfully reduced HIV incidence among certain key populations through the use of targeted intervention, India's HIV epidemic remains one of its great...


    pub_type: 杂志文章


    authors: McClarty LM,Lorway RR,Ramanaik S,Wylie J,Becker ML

    更新日期:2015-01-29 00:00:00

  • Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.

    abstract::Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...


    pub_type: 杂志文章


    authors: Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

    更新日期:2019-01-03 00:00:00

  • Characterization of the genotype and level of attenuation of an influenza A reassortant virus produced by mating the Xia-ts donor virus with A/Beijing/70 (H1N1) wild type virus.

    abstract::Two H1N1 progeny viruses derived by mating the attenuated donor virus, the A/Ningxia/72-ts (H3N2), and the A/Beijing/70 (H1N1) wild type virus were characterized for their genotype and their level of attenuation in susceptible adult volunteers. One progeny virus, clone PX62, was not a reassortant since it received eac...


    pub_type: 临床试验,杂志文章


    authors: Tian SF,Zhang LX,Murphy BR

    更新日期:1984-09-01 00:00:00

  • Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Gúerin.

    abstract::The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycobacterium tuberculosis H37Rv, and also induced lymphocyte proliferative response in mice immunized with ribosomes. In contrast, neither ribosomal proteins nor RNA alone i...


    pub_type: 杂志文章


    authors: Miyazaki C,Ohara N,Yukitake H,Kinomoto M,Matsushita K,Matsumoto S,Mizuno A,Yamada T

    更新日期:1999-01-21 00:00:00

  • Involvement of the complement system in the protection of mice from challenge with respiratory syncytial virus Long strain following passive immunization with monoclonal antibody 18A2B2.

    abstract::Passive immunization of mice with 131 micrograms of the non-neutralizing monoclonal antibody (mAb) 18A2B2, directed against the A subgroup epitope of the G glycoprotein of respiratory syncytial virus Long strain (RSV), confers protection against viral i.n. challenge. The role of the Fc fragment of this antibody as wel...


    pub_type: 杂志文章


    authors: Corbeil S,Seguin C,Trudel M

    更新日期:1996-04-01 00:00:00

  • Detection of measles vaccine in the throat of a vaccinated child.

    abstract::Measles vaccine is widely used, most often in association with mumps and rubella vaccines. We report here the case of a child presenting with fever 8 days after vaccination with a measles-mumps-rubella vaccine. Measles virus was isolated in a throat swab taken 4 days after fever onset. This virus was then further gene...


    pub_type: 杂志文章


    authors: Morfin F,Beguin A,Lina B,Thouvenot D

    更新日期:2002-02-22 00:00:00

  • Adjuvant activity of peptidoglycan monomer and its metabolic products.

    abstract::Peptidoglycan monomer (PGM) is a natural compound of bacterial origin. It is a non-toxic, non-pyrogenic, water-soluble immunostimulator potentiating humoral immune response to ovalbumin (OVA) in mice. It is fast degraded and its metabolic products-the pentapeptide (PP) and the disaccharide (DS)-are excreted from the m...


    pub_type: 杂志文章


    authors: Halassy B,Krstanović M,Frkanec R,Tomasić J

    更新日期:2003-02-14 00:00:00

  • Minimization of chronic plasma viremia in rhesus macaques immunized with synthetic HIV-1 Tat peptides and infected with a chimeric simian/human immunodeficiency virus (SHIV33).

    abstract::HIV-1 Tat protein activates resting cells, rendering them permissive for viral replication. Replication of HIV-1 in vitro is enhanced by intercellular passage of Tat protein and inhibited by anti-Tat antibodies. Tat dependence of HIV-1 replication in vivo during acute, chronic asymptomatic and AIDS stages of infection...


    pub_type: 杂志文章


    authors: Goldstein G,Manson K,Tribbick G,Smith R

    更新日期:2000-06-15 00:00:00

  • Development of a bivalent conjugate vaccine candidate against malaria transmission and typhoid fever.

    abstract::Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a b...


    pub_type: 杂志文章


    authors: An SJ,Scaria PV,Chen B,Barnafo E,Muratova O,Anderson C,Lambert L,Chae MH,Yang JS,Duffy PE

    更新日期:2018-05-17 00:00:00

  • Internationally adopted children: what vaccines should they receive?

    abstract::It is of paramount importance to know the vaccination status in internationally adopted children, so that they can be correctly immunized. This study ascertains the seroprotection rate for vaccine-preventable diseases and the validity of the immunization cards in 637 adopted children. The absence of the immunization c...


    pub_type: 杂志文章


    authors: Cilleruelo MJ,de Ory F,Ruiz-Contreras J,González-González R,Mellado MJ,García-Hortelano M,Villota J,García-Ascaso M,Piñeiro R,Martín-Fontelos P,Herruzo R

    更新日期:2008-10-29 00:00:00

  • DNA vaccine with α-galactosylceramide at prime phase enhances anti-tumor immunity after boosting with antigen-expressing dendritic cells.

    abstract::DNA vaccines contribute to a promising new approach for the generation of cytotoxic T lymphocytes (CTL). DNA vaccines do have several disadvantages, including poor immunogenicity and oncogene expression. We used the natural killer T-cell (NKT) ligand α-galactosylceramide (α-GalCer) as an adjuvant to prime initial DNA ...


    pub_type: 杂志文章


    authors: Kim D,Hung CF,Wu TC,Park YM

    更新日期:2010-10-21 00:00:00

  • A/H1N1 pandemic influenza vaccination: A retrospective evaluation of adverse maternal, fetal and neonatal outcomes in a cohort of pregnant women in Italy.

    abstract::Although concerns about safety of influenza vaccination during pregnancy have been raised in the past, vaccination of pregnant women was recommended in many countries during the 2009 A/H1N1 pandemic influenza. A retrospective cohort study was conducted to evaluate the risk of adverse maternal, fetal and neonatal outco...


    pub_type: 杂志文章


    authors: Fabiani M,Bella A,Rota MC,Clagnan E,Gallo T,D'Amato M,Pezzotti P,Ferrara L,Demicheli V,Martinelli D,Prato R,Rizzo C

    更新日期:2015-05-05 00:00:00

  • The inactivated Cowdria ruminantium vaccine for heartwater protects against heterologous strains and against laboratory and field tick challenge.

    abstract::We previously described that an inactivated vaccine against heartwater prepared from Cowdria ruminantium (Crystal Springs strain) organisms and administered in complete Freund's adjuvant (cFA) protected sheep against homologous needle challenge. Further studies, described herein, demonstrated that this vaccine protect...


    pub_type: 杂志文章


    authors: Mahan SM,Kumbula D,Burridge MJ,Barbet AF

    更新日期:1998-07-01 00:00:00

  • Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice.

    abstract::It has been known that influenza A virus infection induces a cross-protective immunity against infection by viruses with different subtypes of viral envelope proteins, hemagglutinin (HA) and neuraminidase (NA). This heterosubtypic immunity is generally mediated by cytotoxic T lymphocytes (CTL) reactive to specific epi...


    pub_type: 杂志文章


    authors: Takada A,Matsushita S,Ninomiya A,Kawaoka Y,Kida H

    更新日期:2003-07-04 00:00:00

  • Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines - A phase II, randomised, observer-blind study in Gambian infants.

    abstract:BACKGROUND:Two conserved pneumococcal proteins, pneumolysin toxoid (dPly) and pneumococcal histidine triad protein D (PhtD), combined with 10 polysaccharide conjugates from the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) in two investigational pneumococcal vaccine (PHiD-CV/dPl...


    pub_type: 杂志文章,随机对照试验


    authors: Odutola A,Ota MOC,Antonio M,Ogundare EO,Saidu Y,Owiafe PK,Worwui A,Idoko OT,Owolabi O,Kampmann B,Greenwood BM,Alderson M,Traskine M,Swinnen K,Verlant V,Dobbelaere K,Borys D

    更新日期:2019-05-01 00:00:00

  • Association of HLA class II genes with clinical hyporesponsiveness to trivalent inactivated influenza vaccine in children.

    abstract:BACKGROUND:The primary prevention measure for influenza infection has been the use of influenza vaccines. However, even when the vaccine and circulating strains are well-matched, some healthy children do not respond to the vaccine, likely due to a genetic basis for immune hyporesponsiveness. The primary objective of th...


    pub_type: 杂志文章


    authors: Narwaney KJ,Glanz JM,Norris JM,Fingerlin TE,Hokanson JE,Rewers M,Hambidge SJ

    更新日期:2013-02-04 00:00:00

  • Breastfeeding linked to the reduction of both rotavirus shedding and IgA levels after Rotarix® immunization in Mexican infants.

    abstract::We examined potential risk factors on vaccine virus shedding and antibody seroresponse to human rotavirus vaccine (Rotarix) in Mexican infants. Two doses of Rotarix were administered to infants during the first two visits for their routine childhood immunization (∼8 and 15weeks of age) in Mexico City. Infant's charact...


    pub_type: 杂志文章


    authors: Bautista-Marquez A,Velasquez DE,Esparza-Aguilar M,Luna-Cruz M,Ruiz-Moran T,Sugata K,Jiang B,Parashar U,Patel M,Richardson V

    更新日期:2016-10-17 00:00:00

  • Sero-epidemiology of measles and mumps in Korea: impact of the catch-up campaign on measles immunity.

    abstract::A catch-up campaign targeting children aged 8-16 years using measles-rubella (MR) vaccine was conducted during 2001 in Korea. To evaluate the impact of the campaign and assess mumps immunity, human IgG antibodies were detected using ELISA for measles (5826 samples) and mumps (5890 samples) in a national sample of oppo...


    pub_type: 杂志文章,多中心研究


    authors: Kim SS,Han HW,Go U,Chung HW

    更新日期:2004-12-02 00:00:00

  • Immunogenicity and reactogenicity of the Biken acellular pertussis vaccine in young adults.

    abstract::To assess the reactogenicity and immunogenicity of the Biken acellular pertussis vaccine (Pa) following administration of a single vaccine dose to young adults with or without a history of prior pertussis immunization, 104 healthy, male and female adults without primary pertussis immunization were enrolled in Mainz (f...


    pub_type: 杂志文章


    authors: Schmitt HJ,Mohnike K,Zepp F,Herden P,Hosbach P

    更新日期:2000-10-15 00:00:00

  • The influence of gamma inulin and Algammulin on the immune response in sheep to a recombinant antigen of Taenia ovis.

    abstract::Gamma inulin and Algammulin, two new adjuvants, were examined and compared with alum and Freund's Complete/Incomplete Adjuvant (FCA/FIA), for potentiation of cell-mediated immunity (CMI) and humoral immunity in sheep to a recombinant Taenia ovis antigen. The ability to protect sheep when challenged with live T. ovis e...


    pub_type: 杂志文章


    authors: Deol HS,Palmer DG,Dunsmore T,Carnegie PR

    更新日期:1995-04-01 00:00:00