Abstract：
:Staphylococci have become the most common causes of nosocomial bacterial infections, and this fact, along with increasing problems associated with antimicrobial resistance, spurs the need for finding immunotherapeutic alternatives to prevent and possibly treat these infections. Most virulent, clinical isolates of both coagulase-negative staphylococci (CoNS) and Staphylococcus aureus carry the ica locus which encodes proteins that synthesize a polymer of beta-1-6 linked N-acetyl glucosamine residues (PNAG). Animal studies have shown purified PNAG can elicit protective immunity against both CoNS and S. aureus, suggesting its potential as a broadly protective vaccine for many clinically important strains of staphylococci.
journal_name
Vaccinejournal_title
Vaccineauthors
Maira-Litran T,Kropec A,Goldmann D,Pier GBdoi
10.1016/j.vaccine.2003.11.033subject
Has Abstractpub_date
2004-02-17 00:00:00pages
872-9issue
7eissn
0264-410Xissn
1873-2518pii
S0264410X03008302journal_volume
22pub_type
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