Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide.

Abstract:

:Staphylococci have become the most common causes of nosocomial bacterial infections, and this fact, along with increasing problems associated with antimicrobial resistance, spurs the need for finding immunotherapeutic alternatives to prevent and possibly treat these infections. Most virulent, clinical isolates of both coagulase-negative staphylococci (CoNS) and Staphylococcus aureus carry the ica locus which encodes proteins that synthesize a polymer of beta-1-6 linked N-acetyl glucosamine residues (PNAG). Animal studies have shown purified PNAG can elicit protective immunity against both CoNS and S. aureus, suggesting its potential as a broadly protective vaccine for many clinically important strains of staphylococci.

journal_name

Vaccine

journal_title

Vaccine

authors

Maira-Litran T,Kropec A,Goldmann D,Pier GB

doi

10.1016/j.vaccine.2003.11.033

subject

Has Abstract

pub_date

2004-02-17 00:00:00

pages

872-9

issue

7

eissn

0264-410X

issn

1873-2518

pii

S0264410X03008302

journal_volume

22

pub_type

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