Leprosy--in pursuit of a vaccine.

Abstract:

:Clinical leprosy is characterized by varying manifestations between tuberculoid and lepromatous leprosy. In the former state the patient is able to elicit a cell-mediated immune response whereas in the latter, there is usually a humoral response. An understanding of this immunological balance is crucial in the search for a vaccine which will control the disease. The development of a possible anti-Mycobacterium leprae vaccine has been advanced by the isolation of organisms from the infected tissues of the nine-banded armadillo, Dasypus novemcinctus; 125 000 doses can be prepared from one animal. In addition, recent studies on the biochemical activities of these organisms may provide the knowledge required to allow cultivation on a laboratory medium. Eventually it may be possible to produce a combined leprosy:tuberculosis vaccine for use in those parts of the world where both diseases are prevalent.

journal_name

Vaccine

journal_title

Vaccine

authors

Stewart-Tull DE

doi

10.1016/0264-410x(84)90037-9

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

238-48

issue

4

eissn

0264-410X

issn

1873-2518

pii

0264-410X(84)90037-9

journal_volume

2

pub_type

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