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Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers.

Abstract：

BACKGROUND:This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate. METHODS:Eighty subjects were enrolled in playgroups among whom there was at least one infected vaccinee in close contact with a seronegative placebo recipient over 21 days without a confounding infection with wtHPIV3. Following vaccination viral cultures were obtained on nine occasions to detect shedding and transmission of HPIV3cp45. Serum antibody titers were measured before and 7 weeks after vaccination. RESULTS:No child fulfilled the criteria for transmission of HPIV3cp45 giving a risk of transmission of 0.04 (95% CI 0.01-0.19), hence establishing that HPIV3cp45 is less infectious than wtHPIV3 and risk of transmission is not a limitation to further clinical development of this vaccine candidate.

journal_name

Vaccine

journal_title

Vaccine

authors

Madhi SA,Cutland C,Zhu Y,Hackell JG,Newman F,Blackburn N,Murphy BR,Belshe RB,Karron RA,Deatly AM,Gruber WC,Bernstein DI,Wright PF

doi

10.1016/j.vaccine.2005.12.002

subject

Has Abstract

pub_date

2006-03-20 00:00:00

pages

2432-9

issue

13

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)01224-7

journal_volume

24

pub_type

杂志文章,随机对照试验

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