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Tumour-dendritic hybrid cell vaccination for the treatment of patients with malignant melanoma: immunological effects and clinical results.

Abstract：

:Hybrid cell vaccines of autologous tumour cells fused with allogenic dendritic cells (DC) combine the tumour's antigenicity with the immune-stimulatory capacity of mature dendritic cells and allogenic MHC class II molecules to activate T cell help and induce tumour-specific cytotoxic T cells. This concept was tested in a clinical trial with melanoma stage III and IV patients. Seventeen patients were evaluated: one experienced complete, one partial response and six stable disease with long survival times. Eleven of fourteen patients, clinical responders and non-responders alike, mounted high-frequency T cell responses to various tumour-associated antigens. Failing clinical responses correlated with loss of antigenicity.

journal_name

Vaccine

journal_title

Vaccine

authors

Trefzer U,Herberth G,Wohlan K,Milling A,Thiemann M,Sharav T,Sparbier K,Sterry W,Walden P

doi

10.1016/j.vaccine.2005.01.081

subject

Has Abstract

pub_date

2005-03-18 00:00:00

pages

2367-73

issue

17-18

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00015-0

journal_volume

23

pub_type

临床试验,杂志文章

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