Abstract：
:Measles remains a major cause of worldwide infant mortality despite the use of current live attenuated vaccines. New approaches to measles virus (MV) vaccine development are critical to interrupt the spread of MV. In this study, we report the results using a DNA vaccine expressing a fusion of the measles hemagglutinin (H) protein and the complement component, C3d, to enhance the titers of neutralizing antibody. Plasmids were generated that expressed a secreted (s) form of H and the same form fused to three tandem copies of the murine homologue of C3d (sH-3C3d). Analysis of titers of the antibody raised in vaccinated mice indicated that immunizations with the DNA expressing sH-3C3d had higher titers of anti-H antibodies compared to serum from mice vaccinated with DNA expressing sH only. In addition, sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation.
journal_name
Vaccinejournal_title
Vaccineauthors
Green TD,Newton BR,Rota PA,Xu Y,Robinson HL,Ross TMdoi
10.1016/s0264-410x(01)00266-3subject
Has Abstractpub_date
2001-10-12 00:00:00pages
242-8issue
1-2eissn
0264-410Xissn
1873-2518pii
S0264410X01002663journal_volume
20pub_type
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