Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention.


BACKGROUND:Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine live (ZVL) is licensed for people 50 years and older to prevent HZ and PHN. This study evaluated vaccine effectiveness (VE) of ZVL against PHN. METHODS:We conducted an open cohort study within Kaiser Permanente Northern California with continuous accrual of people as they became age-eligible for ZVL. We defined PHN using a PHN diagnosis between 90 and 365 days after an incident episode of HZ. We estimated VE against PHN using Cox regression with a calendar timeline stratified by year of birth and adjusted for sex, race, influenza vaccination, outpatient visit frequency, comorbidities, and immune compromise status. RESULTS:From 2007 to 2016, 1·5 million people entered the study population and 33% received ZVL. During 7·6 million person-years of follow-up, there were 62,205 HZ cases, 4150 (6·7%) of which went on to develop PHN. Overall VE for PHN was 64·8% (95% CI 61·3, 68). VE was 82·8% (95% CI 77·6, 86·7) during the first year after vaccination, 58·3% (95% CI 50.1, 65.2) during the third year, and then waned more gradually to 48·7% (95% CI 30·2, 62·3) during the eighth year. VE in persons vaccinated when aged 80 years or older was similar to VE in younger vaccinees. VE in persons vaccinated when immune compromised was similar to VE in immune competent. CONCLUSIONS:Overall, ZVL was 65% effective against PHN. It was effective in all age groups and provided moderate protection through 8 years.






Klein NP,Bartlett J,Fireman B,Marks MA,Hansen J,Lewis E,Aukes L,Saddier P




Has Abstract


2019-08-23 00:00:00
















  • A comparative study of PENTA vaccine booster doses given at 12, 15, or 18 months of age.

    abstract::For infants immunized with Haemophilus influenzae type b conjugate vaccines, booster immunization is usually recommended in the second year of life, typically between 12 and 18 months. This study assessed the effect of age at booster immunization on pre-immunization antibody trough levels and on subsequent responses, ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scheifele DW,Guasparini R,Lavigne P

    更新日期:1999-02-12 00:00:00

  • Long-lasting balanced immunity and protective efficacy against respiratory syncytial virus in mice induced by a recombinant protein G1F/M2.

    abstract::Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract illness in young children. We have engineered a recombinant candidate vaccine G1F/M2, consisting of a cytotoxic T lymphocyte (CTL) epitope of RSV-M2 protein and a domain of RSV-G protein. In this study, the long-term immunogenici...


    pub_type: 杂志文章


    authors: Zeng R,Qi X,Gong W,Mei X,Wei L,Ma C,Yin X

    更新日期:2007-10-16 00:00:00

  • Immunogenicity and protection conferred by an optimized purified inactivated Zika vaccine in mice.

    abstract::After decades of inconsequential infections, and sporadic outbreaks in the Asia-Pacific region between 2007 and 2013, Zika virus caused a widespread epidemic in South America in 2015 that was complicated by severe congenital infections. After the WHO declared a Public Health Emergency of International Concern in Febru...


    pub_type: 杂志文章


    authors: Lecouturier V,Bernard MC,Berry C,Carayol S,Richier E,Boudet F,Heinrichs J

    更新日期:2019-05-06 00:00:00

  • Expanding immunization coverage in rural India: a review of evidence for the role of community health workers.

    abstract::Poor routine immunization coverage in India has led to a large burden of vaccine-preventable diseases borne by children under 5 years of age. Despite efforts to strengthen infrastructure and service delivery in the past decade, immunization coverage rates have reached a plateau. To meet the formidable needs of India's...


    pub_type: 杂志文章,评审


    authors: Patel AR,Nowalk MP

    更新日期:2010-01-08 00:00:00

  • Development and optimisation of a procedure for the production of Parapoxvirus ovis by large-scale microcarrier cell culture in a non-animal, non-human and non-plant-derived medium.

    abstract::For the production of a chemically inactivated Parapoxvirus ovis (PPVO), an adherent bovine kidney cell line was cultivated on Cytodex-3 microcarriers in suspension culture. The inactivated and purified virus particles have shown immune modulatory activity in several animal models. PPVO was produced by a biphasic batc...


    pub_type: 杂志文章


    authors: Pohlscheidt M,Langer U,Minuth T,Bödeker B,Apeler H,Hörlein HD,Paulsen D,Rübsamen-Waigmann H,Henzler HJ,Reichl U

    更新日期:2008-03-17 00:00:00

  • Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins.

    abstract::Modified vaccinia Ankara (MVA) recombinants expressing single or multiple RSV surface proteins (F or G) are promising potential vaccines. We studied humoral and cellular responses induced by MVA-F and MVA-G in mice, comparing them to a formalin inactivated RSV preparation (FI-RSV) known to increase disease severity. M...


    pub_type: 杂志文章


    authors: Olszewska W,Suezer Y,Sutter G,Openshaw PJ

    更新日期:2004-11-25 00:00:00

  • Immunity to mumps before and after MMR vaccination at 12 years of age in the first generation offered the two-dose immunization programme.

    abstract::Sweden was the first country in the world to introduce a two-dose programme of vaccination against measles, mumps and rubella with a combined vaccine (MMR). It was commenced in 1982 and the vaccination was carried out at the ages of 18 months and 12 years. In 1992-93 the first age-group vaccinated at 18 months reached...


    pub_type: 杂志文章


    authors: Broliden K,Abreu ER,Arneborn M,Böttiger M

    更新日期:1998-01-01 00:00:00

  • Seroprevalence of Bordetella pertussis antibodies and anti-pertussis antibody response after a single dose of reduced-antigen combined diphtheria, tetanus, and acellular pertussis vaccine (Tdap) in pregnant Thai women.

    abstract:BACKGROUND:Maternal immunization with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) has recently been implemented to prevent infant pertussis. Tdap is still not routinely recommended in Thailand, and there are limited data to support or challenge this strategy. OBJECTIVES:The primar...


    pub_type: 杂志文章


    authors: Sompagdee N,Anuwutnavin S,Phongsamart W,Senawong S,Umrod P,Robkhonburi A

    更新日期:2020-03-10 00:00:00

  • Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil.

    abstract::The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the intro...


    pub_type: 杂志文章


    authors: Ribeiro GS,Lima JB,Reis JN,Gouveia EL,Cordeiro SM,Lobo TS,Pinheiro RM,Ribeiro CT,Neves AB,Salgado K,Silva HR,Reis MG,Ko AI

    更新日期:2007-05-30 00:00:00

  • Antibody persistence following booster vaccination against tick-borne encephalitis: 3-year post-booster follow-up.

    abstract::In order to evaluate the long-term immunity 2 and 3 years after booster vaccination against tick-borne encephalitis (TBE) following time intervals 3 years and longer since last TBE immunization, 195 (mean age 50.5+/-15.1 years) and 240 subjects (mean age 47.0+/-15.4 years), respectively, who had received a single boos...


    pub_type: 杂志文章


    authors: Rendi-Wagner P,Paulke-Korinek M,Kundi M,Wiedermann U,Laaber B,Kollaritsch H

    更新日期:2007-06-28 00:00:00

  • The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice.

    abstract::Recently the urgency of developing a pandemic influenza vaccine has lead to the re-evaluation of the use of whole virus vaccine. We have compared the humoral immune response and the protective efficacy of whole and split influenza virus vaccines in mice. Whole virus vaccine was more immunogenic particularly after the ...


    pub_type: 杂志文章


    authors: Cox RJ,Hovden AO,Brokstad KA,Szyszko E,Madhun AS,Haaheim LR

    更新日期:2006-11-10 00:00:00

  • Comparative evaluation of oral and intranasal priming with replication-competent adenovirus 5 host range mutant (Ad5hr)-simian immunodeficiency virus (SIV) recombinant vaccines on immunogenicity and protective efficacy against SIV(mac251).

    abstract::Oral, replication-competent Ad-HIV vaccines are advancing to human trials. Previous evaluation of protective efficacy in non-human primates has primarily followed upper respiratory tract administrations. Here we compared sequential oral (O/O) versus intranasal/oral (I/O) priming of rhesus macaques with Ad5 host range ...


    pub_type: 杂志文章


    authors: Zhou Q,Hidajat R,Peng B,Venzon D,Aldrich MK,Richardson E,Lee EM,Kalyanaraman VS,Grimes G,Gómez-Román VR,Summers LE,Malkevich N,Robert-Guroff M

    更新日期:2007-11-19 00:00:00

  • Gene-based neonatal immune priming potentiates a mucosal adenoviral vaccine encoding mycobacterial Ag85B.

    abstract::Tuberculosis remains a major public health hazard worldwide, with neonates and young infants potentially more susceptible to infection than adults. BCG, the only vaccine currently available, provides some protection against tuberculous meningitis in children but variable efficacy in adults, and is not safe to use in i...


    pub_type: 杂志文章


    authors: Dai G,Rady HF,Huang W,Shellito JE,Mason C,Ramsay AJ

    更新日期:2016-12-07 00:00:00

  • Cost of plasma-derived hepatitis B vaccine production.

    abstract::It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...


    pub_type: 杂志文章


    authors: Mahoney RT

    更新日期:1990-08-01 00:00:00

  • The effect of pneumococcal conjugate vaccines on the incidence of invasive pneumococcal disease caused by ten non-vaccine serotypes in Denmark.

    abstract:BACKGROUND:Surveillance data on invasive pneumococcal disease (IPD) in Denmark (1999-2014) was analysed regarding the incidence and age-distribution due to ten selected non-PCV serotypes (10-Non-PCV). The effect of PCV-7 and PCV-13 vaccines on the 10-Non-PCV IPD incidence was examined. METHODS:IPD cases caused by sero...


    pub_type: 杂志文章


    authors: Slotved HC,Dalby T,Hoffmann S

    更新日期:2016-02-03 00:00:00

  • Relation of activation-induced deaminase (AID) expression with antibody response to A(H1N1)pdm09 vaccination in HIV-1 infected patients.

    abstract::The relevance of CD4+T-cells, viral load and age in the immunological response to influenza infection and vaccination in HIV-1 infected individuals has previously been pointed out. Our study aimed at assessing, in the setting of 2009 A(H1N1)pdm09 influenza vaccination, whether quantification of activation-induced deam...


    pub_type: 杂志文章


    authors: Cagigi A,Pensieroso S,Ruffin N,Sammicheli S,Thorstensson R,Pan-Hammarström Q,Hejdeman B,Nilsson A,Chiodi F

    更新日期:2013-04-26 00:00:00

  • Induction of humoral immune response against Pseudomonas aeruginosa flagellin(1-161) using gold nanoparticles as an adjuvant.

    abstract::Flagellin of Pseudomonas aeruginosa is an important vaccine candidate. N-terminal domains are highly conserved in both type a and type b flagellins. The efficacy of gold nanoparticles (AuNPs) conjugated to N-terminal domains of P. aeruginosa flagellin (flagellin(1-161)), as an immunogen in mice, has been assessed. The...


    pub_type: 杂志文章


    authors: Dakterzada F,Mohabati Mobarez A,Habibi Roudkenar M,Mohsenifar A

    更新日期:2016-03-14 00:00:00

  • Impact of postpartum information about pertussis booster to parents in a university maternity hospital.

    abstract::Parent-to-infant transmission of pertussis remains an issue in France. Although adult booster vaccination was introduced in 2004 as part of a cocooning strategy targeted primarily to parents of young infants, vaccination coverage in this population has remained low. The aim of this study was to evaluate the impact on ...


    pub_type: 杂志文章


    authors: Leboucher B,Sentilhes L,Abbou F,Henry E,Grimprel E,Descamps P

    更新日期:2012-08-10 00:00:00

  • BCG vaccine may generate cross-reactive T cells against SARS-CoV-2: In silico analyses and a hypothesis.

    abstract::The world is facing the rising emergency of SARS-CoV-2. The outbreak of COVID-19 has caused a global public health and economic crisis.Recent epidemiological studies have shown that a possible association of BCG vaccination program with decreased COVID-19-related risks, suggesting that BCG may provide protection again...


    pub_type: 杂志文章


    authors: Tomita Y,Sato R,Ikeda T,Sakagami T

    更新日期:2020-09-22 00:00:00

  • Compliance with immunization against hepatitis B. A pragmatic study in sexually transmitted disease clinics.

    abstract::The efficacy of a vaccine is based primarily on the adherence of the subject to the immunization schedule. This paper compares the compliance rates (CR) for the third dose of hepatitis B virus (HBV) vaccine given according to one of two vaccination schedules among subjects attending two sexually transmitted disease (S...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Dal-Ré R,González A,Ramirez V,Ballesteros J,del Romero J,Bru F

    更新日期:1995-02-01 00:00:00

  • Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis.

    abstract::Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a ...


    pub_type: 杂志文章


    authors: Tewary P,Saxena S,Madhubala R

    更新日期:2006-03-20 00:00:00

  • Brucella abortus vaccine strain RB51 produces low levels of M-like O-antigen.

    abstract::Brucella abortus RB51 is a rough (R) stable vaccine strain used in cattle and is believed to be devoid of O-side chain. We analyzed by use of a panel of monoclonal antibodies (MAbs) directed against seven previously defined O-polysaccharide (O-PS) epitopes the O-chain expression in strain RB51. Two MAbs specific for t...


    pub_type: 杂志文章


    authors: Cloeckaert A,Zygmunt MS,Guilloteau LA

    更新日期:2002-03-15 00:00:00

  • Oral vaccination of broiler chickens against necrotic enteritis using a non-virulent NetB positive strain of Clostridium perfringens type A.

    abstract::Necrotic enteritis (NE) is a severe disease of chickens and turkeys caused by some strains of Clostridium perfringens type A. The disease is well controlled by the use of in-feed antibiotic growth promoters (AGPs). However, due to worldwide public and regulatory pressure to reduce the use of AGPs inter alia, there is ...


    pub_type: 杂志文章


    authors: Mishra N,Smyth JA

    更新日期:2017-12-14 00:00:00

  • The expanding vaccine development pipeline, 1995-2008.

    abstract::Successful launches of recently licensed vaccines contrast with pharmaceutical industry concerns about unfavorable market conditions, making the status and future of vaccine development uncertain. We assessed trends in private-sector vaccine research and development for the period 1995-2008, using a global pharmaceuti...


    pub_type: 历史文章,杂志文章,评审


    authors: Davis MM,Butchart AT,Coleman MS,Singer DC,Wheeler JR,Pok A,Freed GL

    更新日期:2010-02-03 00:00:00

  • Towards the rational design of Th1 adjuvants.

    abstract::Finding adjuvants in order to enhance immune responses against target immunogens has been a major and recurrent issue for the vaccine industry. It is yet to be solved, most particularly in the context of a growing interest in designing new types of vaccines capable of eliciting Th1 immune responses. A review of synthe...


    pub_type: 杂志文章,评审


    authors: Moingeon P,Haensler J,Lindberg A

    更新日期:2001-08-14 00:00:00

  • A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF).

    abstract::The anti-tumor immunologic effects of plasmid DNA vaccines encoding human carcinoembryonic antigen (CEA) fused to mouse granulocyte/macrophage colony-stimulating factor (GM-CSF) were examined. Immunization of C57BL/6 mice with the CEA-GMCSF fusion plasmids in a three injection, high-dose immunization schedule led to T...


    pub_type: 杂志文章


    authors: Lima J,Jenkins C,Guerrero A,Triozzi PL,Shaw DR,Strong TV

    更新日期:2005-01-26 00:00:00

  • Immune response induced by Salmonella typhimurium defective in ppGpp synthesis.

    abstract::Systemic infection by Salmonella typhimurium requires coordinated expression of virulence genes found primarily in Salmonella Pathogenecity Islands (SPIs). We have previously reported that the intracellular signal that induces these virulence genes is a stringent signal molecule, ppGpp [Song et al. J Biol Chem 2003;27...


    pub_type: 杂志文章


    authors: Na HS,Kim HJ,Lee HC,Hong Y,Rhee JH,Choy HE

    更新日期:2006-03-15 00:00:00

  • Analysis of relationships between polymorphisms in the genes encoding the pentameric complex and neutralization of clinical cytomegalovirus isolates.

    abstract:INTRODUCTION:As congenital cytomegalovirus (CMV) infection is one of the major causes of birth defects and developmental abnormalities, it is essential to develop vaccines and therapeutic antibodies against CMV. Clinical trials demonstrated that the subunit vaccine based on glycoprotein B, which had been believed to be...


    pub_type: 杂志文章


    authors: Kobayashi R,Abe M,Oguri K,Torikai M,Nishimura T,Mori H,Koshizuka T,Inoue N

    更新日期:2018-09-25 00:00:00

  • Attenuation and immunogenicity in primates of vaccinia virus recombinants expressing human interleukin-2.

    abstract::Vector-directed lymphokine expression represents a novel approach to the attenuation of live recombinant viruses which might be used as vaccines. Expression of interleukin-2 (IL-2) by recombinant vaccinia virus has been shown to significantly attenuate virus virulence in rodent species without diminishing immunogenici...


    pub_type: 杂志文章


    authors: Flexner C,Moss B,London WT,Murphy BR

    更新日期:1990-02-01 00:00:00

  • Revaccination with 23-valent pneumococcal polysaccharide vaccine in the Japanese elderly is well tolerated and elicits immune responses.

    abstract:BACKGROUND:Following primary vaccination of adults ⩾65years of age with 23-valent pneumococcal polysaccharide vaccine (PPSV23), immune responses increase and thereafter appear to decrease over time. With increased life expectancy worldwide, revaccination with PPSV23 may be required for continued protection of the elder...


    pub_type: 杂志文章,多中心研究


    authors: Kawakami K,Kishino H,Kanazu S,Toshimizu N,Takahashi K,Sterling T,Wang M,Musey L

    更新日期:2016-07-19 00:00:00