Abstract:
BACKGROUND:Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine live (ZVL) is licensed for people 50 years and older to prevent HZ and PHN. This study evaluated vaccine effectiveness (VE) of ZVL against PHN. METHODS:We conducted an open cohort study within Kaiser Permanente Northern California with continuous accrual of people as they became age-eligible for ZVL. We defined PHN using a PHN diagnosis between 90 and 365 days after an incident episode of HZ. We estimated VE against PHN using Cox regression with a calendar timeline stratified by year of birth and adjusted for sex, race, influenza vaccination, outpatient visit frequency, comorbidities, and immune compromise status. RESULTS:From 2007 to 2016, 1·5 million people entered the study population and 33% received ZVL. During 7·6 million person-years of follow-up, there were 62,205 HZ cases, 4150 (6·7%) of which went on to develop PHN. Overall VE for PHN was 64·8% (95% CI 61·3, 68). VE was 82·8% (95% CI 77·6, 86·7) during the first year after vaccination, 58·3% (95% CI 50.1, 65.2) during the third year, and then waned more gradually to 48·7% (95% CI 30·2, 62·3) during the eighth year. VE in persons vaccinated when aged 80 years or older was similar to VE in younger vaccinees. VE in persons vaccinated when immune compromised was similar to VE in immune competent. CONCLUSIONS:Overall, ZVL was 65% effective against PHN. It was effective in all age groups and provided moderate protection through 8 years.
journal_name
Vaccinejournal_title
Vaccineauthors
Klein NP,Bartlett J,Fireman B,Marks MA,Hansen J,Lewis E,Aukes L,Saddier Pdoi
10.1016/j.vaccine.2019.07.004subject
Has Abstractpub_date
2019-08-23 00:00:00pages
5422-5427issue
36eissn
0264-410Xissn
1873-2518pii
S0264-410X(19)30882-5journal_volume
37pub_type
杂志文章相关文献
VACCINE文献大全abstract:BACKGROUND:In the Netherlands, different hepatitis B vaccination schedules have been used for children born to HBV-infected mothers. All schedules included a birth dose of hepatitis B immunoglobuline (HBIg). We assessed determinants of perinatal HBV transmission and determinants of anti-HBs titers in infants born to HB...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.12.071
更新日期:2012-02-21 00:00:00
abstract:BACKGROUND:Use of a polysaccharide vaccine challenge to demonstrate immunologic memory after priming with capsular group C meningococcal conjugate vaccines (MenCC) risks induction of immunologic hyporesponsiveness. For this reason, MenCC vaccines are now used as probes of immunologic memory, however, no studies have de...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2016.10.038
更新日期:2016-12-07 00:00:00
abstract:OBJECTIVE:We investigated whether and to what extent the uptake of the Human Papillomavirus (HPV) vaccine by girls aged 12-18 was related to the cervical cancer screening history of age-appropriate older female household members (assumed to be their mothers) in Flanders (Belgium). METHODS:We studied administrative rec...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.08.039
更新日期:2011-10-26 00:00:00
abstract:OBJECTIVE:Implementing national-level vaccination programs involves long-term investment, which can be a significant financial burden, particularly in resource-limited settings. Although many studies have assessed the economic impacts of providing vaccinations, evidence on the positive and negative implications of huma...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.08.014
更新日期:2016-09-14 00:00:00
abstract::Through the specific and tight interaction between streptavidin and biotin, a novel platform was developed to allow for rapid (less than 2h), efficient and durable display of streptavidin-tagged bioactive GM-CSF on the surface of biotinylated B16.F10 tumor cells. This technology involved biotinylation of the cell memb...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.04.031
更新日期:2006-06-19 00:00:00
abstract::Brucella abortus RB51 is a rough (R) stable vaccine strain used in cattle and is believed to be devoid of O-side chain. We analyzed by use of a panel of monoclonal antibodies (MAbs) directed against seven previously defined O-polysaccharide (O-PS) epitopes the O-chain expression in strain RB51. Two MAbs specific for t...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00035-x
更新日期:2002-03-15 00:00:00
abstract::EG95 is a recombinant vaccine protein that elicits protection against hydatid disease in sheep. Previous studies have shown that the host-protective epitopes on EG95 depend on correct conformation and cannot be represented by simple "linear" peptides. By screening random peptide phage display libraries with polyclonal...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.11.096
更新日期:2009-02-11 00:00:00
abstract::The baculovirus-insect cell expression system is a well known tool for the production of complex proteins. The technology is also used for commercial manufacture of various veterinary and human vaccines. This review paper provides an overview of how this technology can be applied to produce a multitude of vaccine cand...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2012.01.016
更新日期:2012-02-27 00:00:00
abstract:INTRODUCTION:Annual influenza vaccine coverage for young adults (including college students) remains low, despite a 2011 US recommendation for annual immunization of all people 6 months and older. College students are at high risk for influenza morbidity given close living and social spaces and extended travel during s...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.02.033
更新日期:2015-03-30 00:00:00
abstract::Herpes zoster, a common disease, has an important impact on the health of adults, particularly the elderly, and the health system. This study evaluated the disease burden and epidemiological characteristics of herpes zoster in Taiwan. Using herpes zoster-related ICD-9-CM codes used on Taiwan's National Health Insuranc...
journal_title:Vaccine
pub_type: 历史文章,杂志文章
doi:10.1016/j.vaccine.2009.11.029
更新日期:2010-02-03 00:00:00
abstract::We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes a systemic infection allowing the isolation of viable chlamydiae from several organs for several days post-infection (p.i.). In particular, spleen infection occurred up to Day 7 p.i. in 100% of anima...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2003.09.035
更新日期:2004-03-12 00:00:00
abstract::In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(99)00236-4
更新日期:1999-10-01 00:00:00
abstract::Since vaccination against human papillomavirus (HPV) became available, awareness of HPV has dramatically increased. Implementation of a vaccine program varies internationally yet no studies have explored the influence this has on the public's knowledge of HPV. The present study aimed to explore differences in awarenes...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.11.083
更新日期:2013-01-21 00:00:00
abstract::Inactivated influenza vaccine (Ivac) has had an important impact on reducing attack rates of influenza and reducing the severity of illness amongst the vaccinees who still acquire infection. Ivac is most efficacious amongst young, otherwise healthy subjects and least effective against elderly at high risk. This is in ...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0264-410x(99)00508-3
更新日期:2000-02-25 00:00:00
abstract::Pertactin/P.69, a surface-associated polypeptide antigen of Bordetella pertussis, was expressed in a Salmonella typhimurium aroA aroD vaccine strain, BRD509, using different expression systems, and the immune response in mice against these constructs was compared. Initially, Pertactin/P.69 was expressed on the surface...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(96)00036-9
更新日期:1996-10-01 00:00:00
abstract:INTRODUCTION:The Global Vaccine Action Plan and the Regional Immunization Action Plan of the Americas call for countries to improve immunization data quality. Immunization information systems, particularly electronic immunization registries (EIRs), can help to facilitate program management and increase coverage. Howeve...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.10.083
更新日期:2018-11-29 00:00:00
abstract::Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine develop...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.02.003
更新日期:2014-04-11 00:00:00
abstract::The World Health Organization's Expanded Programme on Immunization has led to a dramatic rise in worldwide vaccination rates over the past 40years, yet 19.4 million infants remain underimmunized each year. Many of these infants have received at least one vaccine dose but may remain unprotected because they did not rec...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.05.094
更新日期:2018-05-24 00:00:00
abstract::Epitopes in HIV polymerase were analyzed by peptide binding to human leukocyte antigen (HLA) A0201 molecules, the most frequent HLA class in the Caucasian population. We found that HIV-1 protease peptides representing both the wild type and anticipated drug resistance variants of the sequence bound well to HLA-A0201. ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.08.019
更新日期:2006-05-22 00:00:00
abstract::The persistence of anti-HBs protective levels in groups of children who had been immunized against Hepatitis B 5 and 10 years earlier, in their first year of life, has been studied. The results were analyzed according to the type of vaccine (both plasma-derived and DNA recombinant) and the number of doses administered...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(96)00140-5
更新日期:1996-11-01 00:00:00
abstract::As companies, countries, and governments consider investments in vaccine production for routine immunization and outbreak response, understanding the complexity and cost drivers associated with vaccine production will help to inform business decisions. Leading multinational corporations have good understanding of the ...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2017.06.003
更新日期:2017-07-24 00:00:00
abstract:INTRODUCTION:Vaccination of health care workers (HCW) reduces transmission of influenza among patients, yet uptake of vaccination remains low. If vaccination education is integrated into the early medical school curriculum, will student attitudes toward the vaccine change? The objectives of the study were to: (1) Deter...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.11.043
更新日期:2014-01-16 00:00:00
abstract:BACKGROUND:Surveillance data on invasive pneumococcal disease (IPD) in Denmark (1999-2014) was analysed regarding the incidence and age-distribution due to ten selected non-PCV serotypes (10-Non-PCV). The effect of PCV-7 and PCV-13 vaccines on the 10-Non-PCV IPD incidence was examined. METHODS:IPD cases caused by sero...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.12.056
更新日期:2016-02-03 00:00:00
abstract:INTRODUCTION:Clinical trial data management (DM) conducted during outbreaks like that of Ebola virus disease (EVD) in West Africa, 2014-2016, has to adapt to specific, unique circumstances. CTU Bern was asked to set up a safe data capture/management system that could be launched within a few weeks and cover two differe...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.09.094
更新日期:2019-11-15 00:00:00
abstract::We investigated the therapeutic effects of romurtide, a synthetic muramyl dipeptide derivative, on experimental thrombocytopenia induced by carboplatin in cynomolgus monkeys. A prolonged thrombocytopenia due to a severe myelosuppression was induced by carboplatin. Romurtide given subcutaneously elevated significantly ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(96)00064-3
更新日期:1996-10-01 00:00:00
abstract::This study investigates the background to low uptake of nasal influenza vaccination in Polish pupils in Edinburgh, Scotland. In autumn 2018, one week after their child's nasal flu vaccination sessions, 365 Polish parents were sent a questionnaire exploring influences on their vaccination choices. The questionnaire inc...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.02.028
更新日期:2020-03-17 00:00:00
abstract::A rapid and sensitive assay using surface plasmon resonance (SPR) immunoassay has been developed for the detection of Clostridium perfringens beta-toxin. The SPR immunoassay was conducted off-line by passing fermentation broth by a sensor chip coated with a monoclonal antibody specific for C. perfringens beta-toxin. Q...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)00282-x
更新日期:1998-05-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating epizootic of porcine species. Current vaccines are inadequate to control the disease burden and outbreaks in the field. We report a novel baculovirus vaccine vector with White spot syndrome virus immediate early 1 shuttle promoter, wit...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.08.101
更新日期:2013-11-04 00:00:00
abstract::In Portugal, the 7-valent pneumococcal conjugate vaccine (PCV7) was not introduced in the national immunization plan but was commercially available between 2001 and 2010. We studied serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae carried by children in 2009 and 2010. Vaccination with PC...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.02.045
更新日期:2016-03-29 00:00:00
abstract:BACKGROUND:Shigellae cause severe disease in endemic countries, especially in children. Several efficacy trials have been conducted with candidate vaccines against Shigellae, but the lack of protection, the safety concerns, or manufacturing challenges hindered successful market approval. Conjugated vaccines have been s...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2015.06.102
更新日期:2015-08-26 00:00:00