Choice of measures of vaccination and estimates of risk of pediatric pertussis.

Abstract:

BACKGROUND:Vaccination uptake at the individual level can be assessed in a variety of ways, including traditional measures of being up-to-date (UTD), measures of UTD that consider dose timing, like age-appropriate vaccination, and risk reduction from individual doses. This analysis compared methods of operationalizing vaccination uptake and corresponding risk of pertussis infection. METHODS:City-wide case-control study of children in Philadelphia aged 3 months through 6 years, between 2001 and 2013. Multiple logistic regression was used to isolate the independent effects of each measure of vaccination uptake and the corresponding relative odds of pertussis. RESULTS:Being UTD on vaccinations was associated with a 52% reduction in risk of pertussis (OR 0.48, 95% CI: 0.34, 0.69). Evaluation of delayed receipt of vaccine versus on-time UTD yielded similar results. There was a decrease in risk of pertussis for each additional dose received with the greatest reduction in pertussis infection observed from the first (OR 0.48, 95% CI: 0.28, 0.83) and second dose (OR 0.17, 95% CI: 0.08, 0.34). Additional doses conferred minimal additional protection in this age group. CONCLUSION:Examining vaccination status by individual doses may offer improved predictive capacity for identifying children at risk for pertussis infection compared to the traditional UTD measure.

journal_name

Vaccine

journal_title

Vaccine

authors

Goldstein ND,Newbern EC,Evans AA,Drezner K,Welles SL

doi

10.1016/j.vaccine.2015.06.033

subject

Has Abstract

pub_date

2015-07-31 00:00:00

pages

3970-5

issue

32

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(15)00822-1

journal_volume

33

pub_type

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