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Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults.

Abstract：

:This study examined the effect of congestive heart failure (CHF) on immune responses to influenza vaccination (2000-2001 preparation) in three groups of older adults including healthy, Class II and Class III/IV CHF. Serum antibody titers measured by hemagglutination inhibition (HI), and interferon-gamma (IFN-gamma), interleukin-10 (IL-10) and granzyme B (GrzB) levels in ex vivo virus-activated mononuclear cell cultures showed significant responses from pre-vaccination to 4 and 12 weeks post-vaccination (P<0.01). There was a trend for lower GrzB and higher IFN-gamma and IL-10 levels in healthy versus CHF groups (P<0.06) for all viral strains at 4 weeks. HI titers did not differ between groups. In the regression model, Grz B levels were significantly predicted by the IFN-gamma:IL-10 ratio and performance on the 6 min Walk Test; age and CHF dropped out of the model. In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences.

journal_name

Vaccine

journal_title

Vaccine

authors

McElhaney JE,Herre JM,Lawson ML,Cole SK,Burke BL,Hooton JW

doi

10.1016/j.vaccine.2003.08.032

subject

Has Abstract

pub_date

2004-01-26 00:00:00

pages

681-8

issue

5-6

eissn

0264-410X

issn

1873-2518

pii

S0264410X03006455

journal_volume

22

pub_type

杂志文章

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