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DNA vaccination against v-src oncogene-induced tumours in congenic chickens.

Abstract：

:DNA vaccination is particularly efficient for induction of cytotoxic T-lymphocyte (CTL) response. In our experiments, we used MHC(B) congenic chicken lines CB and CC (regressors and progressors of v-src-induced tumours, respectively) and a mutated, non-oncogenic v-src gene construct as the DNA vaccine. A high degree of vaccine protection against oncogenic v-src challenge was achieved in the CB line chickens. CTL response was demonstrated in vitro and by adoptive transfer of immune cells to the syngeneic host and to the CC line chickens rendered tolerant to CB cells. In the CC line chickens we observed tumour growth retardation after a low-dose DNA vaccination administered to immature recipients while higher amounts of DNA vaccine in immunocompetent chickens exerted an enhancing effect.

journal_name

Vaccine

journal_title

Vaccine

authors

Plachý JV,Hejnar JV,Trtková K,Trejbalová K,Svoboda J,Hála K

doi

10.1016/s0264-410x(01)00181-5

subject

Has Abstract

pub_date

2001-08-14 00:00:00

pages

4526-35

issue

31

eissn

0264-410X

issn

1873-2518

pii

S0264410X01001815

journal_volume

19

pub_type

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