Abstract:
:The anti-tumor immunologic effects of plasmid DNA vaccines encoding human carcinoembryonic antigen (CEA) fused to mouse granulocyte/macrophage colony-stimulating factor (GM-CSF) were examined. Immunization of C57BL/6 mice with the CEA-GMCSF fusion plasmids in a three injection, high-dose immunization schedule led to T cell and antibody responses specific for CEA. Mice injected with CEA-GMCSF fusion plasmids also developed IgG autoantibodies to GM-CSF. Tumor challenge with the CEA-expressing syngeneic mouse adenocarcinoma line, MC38-CEA-2, showed delayed tumor growth in mice immunized with the CEA-GMCSF fusion plasmids but complete protection in mice immunized with plasmid encoding CEA alone. In contrast, a single low-dose immunization with CEA-GMCSF fusion plasmids provided better tumor protection than low-dose CEA plasmid alone and resulted in lower titers of GM-CSF antibodies.
journal_name
Vaccinejournal_title
Vaccineauthors
Lima J,Jenkins C,Guerrero A,Triozzi PL,Shaw DR,Strong TVdoi
10.1016/j.vaccine.2004.08.043subject
Has Abstractpub_date
2005-01-26 00:00:00pages
1273-83issue
10eissn
0264-410Xissn
1873-2518pii
S0264-410X(04)00677-2journal_volume
23pub_type
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