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A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF).

Abstract：

:The anti-tumor immunologic effects of plasmid DNA vaccines encoding human carcinoembryonic antigen (CEA) fused to mouse granulocyte/macrophage colony-stimulating factor (GM-CSF) were examined. Immunization of C57BL/6 mice with the CEA-GMCSF fusion plasmids in a three injection, high-dose immunization schedule led to T cell and antibody responses specific for CEA. Mice injected with CEA-GMCSF fusion plasmids also developed IgG autoantibodies to GM-CSF. Tumor challenge with the CEA-expressing syngeneic mouse adenocarcinoma line, MC38-CEA-2, showed delayed tumor growth in mice immunized with the CEA-GMCSF fusion plasmids but complete protection in mice immunized with plasmid encoding CEA alone. In contrast, a single low-dose immunization with CEA-GMCSF fusion plasmids provided better tumor protection than low-dose CEA plasmid alone and resulted in lower titers of GM-CSF antibodies.

journal_name

Vaccine

journal_title

Vaccine

authors

Lima J,Jenkins C,Guerrero A,Triozzi PL,Shaw DR,Strong TV

doi

10.1016/j.vaccine.2004.08.043

subject

Has Abstract

pub_date

2005-01-26 00:00:00

pages

1273-83

issue

10

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(04)00677-2

journal_volume

23

pub_type

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