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Considerations in the design of vaccines that induce CD8 T cell mediated immunity.

Abstract：

:The protective capacity of many currently used vaccines is based on induction of neutralizing antibodies. Many pathogens, however, have adapted themselves in different ways to escape antibody-based immune protection. In particular, for those infections against which conventional neutralizing antibody-based vaccinations appear challenging, CD8 T-cells are considered to be promising candidates for vaccine targeting. The design of vaccines that induce robust and long-lasting protective CD8 T-cell responses however imposes new challenges, as many factors such as kinetics and efficiency of antigen-processing and presentation by antigen presenting cells, T-cell repertoire and cytokine environment during T cell priming contribute to the specificity and functionality of CD8 T-cell responses. In the following, we review the most prominent aspects that underlie CD8 T-cell induction and discuss how this knowledge may help to improve the design of efficient CD8 T-cell inducing vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Zaiss DM,Boog CJ,van Eden W,Sijts AJ

doi

10.1016/j.vaccine.2010.08.101

subject

Has Abstract

pub_date

2010-11-16 00:00:00

pages

7716-22

issue

49

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)01291-0

journal_volume

28

pub_type

杂志文章,评审

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