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Modular epitope binding predicts influenza quasispecies dominance and vaccine effectiveness: Application to 2018/19 season.

Abstract：

:The modular binding sites on the influenza A(H3N2) hemagglutinin protein are under significant pressure to acquire mutations in order to evade human antibody recognition. Analysis of these hemagglutinin epitopes in the strains circulating during 2017/18 and early 2018/19 identified the emergence of a new antigenic cluster that has grown from 4% of circulating strains to 11%. We regressed our module-based antigenic distance, pepitope, with A(H3N2) vaccine effectiveness from recent studies conducted by the US Centers for Disease Control and Prevention (r2 = 0.92), and we used this to estimate that the 2018/19 vaccines will protect against most circulating A(H3N2) strains. The pEpitope model is useful for A(H3N2) influenza vaccine virus selection and development, and it has the potential to aid national or regional regulatory authorities in making geographically localized decisions.

journal_name

Vaccine

journal_title

Vaccine

authors

Bonomo ME,Kim RY,Deem MW

doi

10.1016/j.vaccine.2019.03.068

subject

Has Abstract

pub_date

2019-05-27 00:00:00

pages

3154-3158

issue

24

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(19)30417-7

journal_volume

37

pub_type

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