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Age-dependent tolerance to an endogenous tumor-associated antigen.

Abstract：

:Immunologic tolerance to endogenous antigens reduces antitumor responses. Gp70 is an endogenous tumor-associated antigen (TAA) of the BALB/c-derived colon carcinoma CT26. We found that expression of gp70 mRNA is detectable in tissues of mice 8 months of age and older. We showed that expression of gp70 establishes immunologic tolerance and affects antitumor immunity in a similarly age-dependent manner using gp70-deficient mice. We found that tumors grew in all gp70-sufficient mice, while approximately half of gp70-deficient mice controlled tumor growth with endogenous T-cell responses. Protection in gp70-deficient mice correlated with more robust gp70-specific CTL responses, and increased numbers and avidity of responding antigen-specific T cells after vaccination. We conclude that immunosurveillance may decline with age due to increased or de novo peripheral expression of endogenous TAAs.

journal_name

Vaccine

journal_title

Vaccine

authors

McWilliams JA,Sullivan RT,Jordan KR,McMahan RH,Kemmler CB,McDuffie M,Slansky JE

doi

10.1016/j.vaccine.2008.01.052

subject

Has Abstract

pub_date

2008-03-28 00:00:00

pages

1863-1873

issue

15

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00123-0

journal_volume

26

pub_type

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