当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Comparative immunogenicity in children of mammalian cell-derived recombinant hepatitis B vaccine and plasma-derived hepatitis B vaccine.

Comparative immunogenicity in children of mammalian cell-derived recombinant hepatitis B vaccine and plasma-derived hepatitis B vaccine.

Abstract：

:Three doses of hepatitis B vaccine were given at 2, 4 and 9 months of age to 220 Senegalese infants living in the Dakar area of Senegal. Half of the infants received 5 micrograms plasma-derived hepatitis B vaccine (Hevac B) and the remainder 20 micrograms mammalian cell-derived recombinant hepatitis B vaccine (GenHevac B). Both vaccines contain S and pre-S2 encoded proteins; however, the recombinant vaccine had a much higher pre-S2 content than the plasma-derived vaccine. Adverse reactions to both vaccines were limited to mild and transient soreness at the injection site. Fever was reported in 14-21% of the infants and was likely to be related to DTP-polio vaccine which was given simultaneously. After the two first doses, seroconversion rates and geometric mean titres of anti-HBs were higher in infants receiving the recombinant vaccine than in infants receiving the plasma-derived vaccine. After completion of vaccination, all infants in both groups had protective levels of anti-HBs antibodies. The recombinant vaccine induced more rapidly antibodies directed against S and pre-S2 epitopes. Anti-pre-S2 antibodies were detected after the first injection of GenHevac B and only after the third injection of Hevac B. From the data, GenHevac B vaccine is expected to be as effective as Hevac B vaccine for controlling hepatitis B infection.

journal_name

Vaccine

journal_title

Vaccine

authors

Coursaget P,Bringer L,Sarr G,Bourdil C,Fritzell B,Blondeau C,Yvonnet B,Chiron JP,Jeannée E,Guindo S

doi

10.1016/0264-410x(92)90067-t

subject

Has Abstract,Author List Incomplete

pub_date

1992-01-01 00:00:00

pages

379-82

issue

6

eissn

0264-410X

issn

1873-2518

pii

0264-410X(92)90067-T

journal_volume

10

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Safety and immunogenicity of influenza A(H5N1) vaccine stored up to twelve years in the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS).

    abstract：BACKGROUND:As part of the U.S. Department of Health and Human Services (HHS) Pandemic Influenza Plan preparedness and response strategy, the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS) program was established by the Biomedical Advanced Research and Development Authority (BARDA) in 2005 with the goal of bu...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2018.11.069

    authors： Oshansky CM,Zhou J,Gao Y,Schweinle JE,Biscardi K,DeBeauchamp J,Pavetto C,Wollish A,BRITE Study Coordination Team.,Webby RJ,Cioce V,Donis RO,Bright RA

    更新日期：2019-01-14 00:00:00

  • Schistosoma japonicum calcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice.

    abstract：:A family of platyhelminth tegument-specific proteins comprising of one or two calcium ion binding EF-hand and a dynein light chain-like domain, termed tegumental proteins, are considered as candidates of vaccine. In this study, we cloned and characterized SjTP22.4, a novel membrane-anchored tegumental protein in Schis...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.056

    authors： Zhang Z,Xu H,Gan W,Zeng S,Hu X

    更新日期：2012-07-20 00:00:00

  • SOCS1 downregulation in dendritic cells promotes memory T-cell responses.

    abstract：:SOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and ant...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.11.020

    authors： Aldrich M,Sanders D,Lapteva N,Huang XF,Chen SY

    更新日期：2008-02-20 00:00:00

  • A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis.

    abstract：:Forty-four adult patients with cutaneous leishmaniasis (CL) were enrolled in a randomized, double-blind, controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE vaccine (consisting of 5, 10, or 20 μg recombinant Leishmania polyprotein LEISH-F1 ant...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2010.07.063

    authors： Nascimento E,Fernandes DF,Vieira EP,Campos-Neto A,Ashman JA,Alves FP,Coler RN,Bogatzki LY,Kahn SJ,Beckmann AM,Pine SO,Cowgill KD,Reed SG,Piazza FM

    更新日期：2010-09-14 00:00:00

  • Responses of varicella zoster virus (VZV)-specific immunity in seropositive adults after inhalation of inactivated or live attenuated varicella vaccine.

    abstract：:To examine boostering of varicella zoster virus (VZV)-specific immunity in seropositive adults after nasal inhalation of heat-inactivated or live attenuated varicella vaccine, we determined specific cellular immunity, IgG antibody in sera and secretory IgA antibody in saliva before and after the inhalation. The mean t...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00408-5

    authors： Terada K,Niizuma T,Ogita S,Kataoka N

    更新日期：2002-11-01 00:00:00

  • Efficacy, safety and immunogenicity of RIX4414 in Japanese infants during the first two years of life.

    abstract：:A phase III, randomized, double-blind study evaluated the efficacy, reactogenicity, safety and immunogenicity of a human rotavirus vaccine, RIX4414 in Japanese infants aged 6-14 weeks when administered as two doses (0, 1-month schedule). Efficacy against any and severe rotavirus gastroenteritis leading to medical inte...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2011.05.017

    authors： Kawamura N,Tokoeda Y,Oshima M,Okahata H,Tsutsumi H,Van Doorn LJ,Muto H,Smolenov I,Suryakiran PV,Han HH

    更新日期：2011-08-26 00:00:00

  • Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.

    abstract：:Optimized DNA vectors were constructed comprising the proteome of SIV including the structural, enzymatic, regulatory, and accessory proteins. In addition to native antigens as produced by the virus, fusion proteins and modified antigens with altered secretion, cellular localization and stability characteristics were ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.12.056

    authors： Kulkarni V,Jalah R,Ganneru B,Bergamaschi C,Alicea C,von Gegerfelt A,Patel V,Zhang GM,Chowdhury B,Broderick KE,Sardesai NY,Valentin A,Rosati M,Felber BK,Pavlakis GN

    更新日期：2011-09-09 00:00:00

  • Immunological cross-reactivity against a drug mutated HIV-1 protease epitope after DNA multi-CTL epitope construct immunization.

    abstract：:Epitopes in HIV polymerase were analyzed by peptide binding to human leukocyte antigen (HLA) A0201 molecules, the most frequent HLA class in the Caucasian population. We found that HIV-1 protease peptides representing both the wild type and anticipated drug resistance variants of the sequence bound well to HLA-A0201. ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.08.019

    authors： Boberg A,Sjöstrand D,Rollman E,Hinkula J,Zuber B,Wahren B

    更新日期：2006-05-22 00:00:00

  • A single dose of an ISCOM influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect Cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses.

    abstract：:Since the production of influenza vaccines is complicated by the continuous variation of these viruses, it would be desirable to develop vaccines that induce cross-protective immunity against influenza virus strains that circulate in subsequent winter epidemics. We have recently demonstrated that antibodies induced af...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00262-6

    authors： Rimmelzwaan GF,Baars M,van Amerongen G,van Beek R,Osterhaus AD

    更新日期：2001-10-12 00:00:00

  • Selection of novel TB vaccine candidates and their evaluation as DNA vaccines against aerosol challenge.

    abstract：:Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against Mycobacterium tuberculosis challenge in a guinea pig aerosol infection...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.05.025

    authors： Vipond J,Vipond R,Allen-Vercoe E,Clark SO,Hatch GJ,Gooch KE,Bacon J,Hampshire T,Shuttleworth H,Minton NP,Blake K,Williams A,Marsh PD

    更新日期：2006-09-11 00:00:00

  • Effectiveness of Jeryl Lynn-containing vaccine in Spanish children.

    abstract：:We evaluated the effectiveness of the Jeryl Lynn strain vaccine in a large outbreak of mumps in Navarre, Spain, 2006-2008. Each of the 241 cases of mumps occurring in children over 15 months of age born between 1998 and 2005 was compared with 5 controls individually matched by sex, birth date, district of residence an...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.02.001

    authors： Castilla J,García Cenoz M,Arriazu M,Fernández-Alonso M,Martínez-Artola V,Etxeberria J,Irisarri F,Barricarte A

    更新日期：2009-03-26 00:00:00

  • Protection against tick-borne encephalitis virus isolated in Japan by active and passive immunization.

    abstract：:In order to establish a firm preventive measure for tick-borne encephalitis (TBE) in Japan, we evaluated the immune response of European vaccine against Japanese TBE virus strain (Oshima 5-10) for man and mouse. Furthermore, the efficacy of pre- and post-exposure protection by a polyclonal rabbit anti-TBE virus serum ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00360-0

    authors： Chiba N,Osada M,Komoro K,Mizutani T,Kariwa H,Takashima I

    更新日期：1999-03-17 00:00:00

  • Deletion of the A35 gene from Modified Vaccinia Virus Ankara increases immunogenicity and isotype switching.

    abstract：:We show here that the immunogenicity of the Modified Vaccinia Ankara MVA vaccine strain can be improved by deletion of the A35 gene, without diminishing the ability of the virus to replicate. Deletion of the A35 gene resulted in increased virus-specific immunoglobulin production, class switching to IgG isotypes, and v...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.02.023

    authors： Rehm KE,Roper RL

    更新日期：2011-04-12 00:00:00

  • Age-dependent immune responses and immune protection after avian coronavirus vaccination.

    abstract：:Infectious bronchitis virus (IBV) is an endemic disease of chickens and a major contributor to economic losses for the poultry industry despite vaccination. Recent observations indicated that chicks may have an immature immune system immediately after hatching when vaccinated for IBV. Therefore we hypothesized that ea...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.04.026

    authors： van Ginkel FW,Padgett J,Martinez-Romero G,Miller MS,Joiner KS,Gulley SL

    更新日期：2015-05-28 00:00:00

  • Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis.

    abstract：:In some cases of atopic dermatitis (AD), a possible pathological contribution to disease development by Candida albicans (C. albicans) has been suggested. AD patients with severe symptoms showing positive capsulated hydrolic carrier polymer radioallergosorbent test (CAP-RAST) against C. albicans demonstrated significa...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00218-9

    authors： Suenobu N,Kweon MN,Kiyono H

    更新日期：2002-07-26 00:00:00

  • An immunogenicity study of a newly introduced purified Vero cell rabies vaccine (Abhayrab) manufactured in India.

    abstract：:Purified Vero cell culture rabies vaccine "Abhayrab" manufactured by Human Biologicals Institute, Ooty, India was subjected for immunogenicity studies. Pre-exposure study was undertaken on 60 healthy volunteers (Group I) with vaccination on days 0, 7 and 21. A group of 75 patients of category II (Group II), 67 of cate...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.08.001

    authors： Sampath G,Reddy SV,Rao ML,Rao YU,Palaniappan C

    更新日期：2005-01-04 00:00:00

  • Ultraviolet-C irradiation for inactivation of viruses in foetal bovine serum.

    abstract：:Foetal Bovine Serum (FBS) and porcine trypsin are one of the essential raw materials used in the manufacturing of cell culture based viral vaccines. Being from animal origin, these raw materials can potentially contaminate the final product by known or unknown adventitious agents. The issue is more serious in case of ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.06.008

    authors： Vaidya V,Dhere R,Agnihotri S,Muley R,Patil S,Pawar A

    更新日期：2018-07-05 00:00:00

  • Oral cholera vaccine delivery strategy in India: Routine or campaign?-A scoping review.

    abstract：:Oral Cholera Vaccine (OCV) has been recognized as an adjunct tool for prevention and control of cholera. However, policy directions are currently unavailable in India to guide the vaccine delivery. We conducted a scoping review to inform the policy about the scopes and challenges of different strategic choices of OCV ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2019.07.082

    authors： Ray A,Sarkar K,Haldar P,Ghosh R

    更新日期：2020-02-29 00:00:00

  • A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity.

    abstract：:Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.02.038

    authors： Carrion R Jr,Patterson JL,Johnson C,Gonzales M,Moreira CR,Ticer A,Brasky K,Hubbard GB,Moshkoff D,Zapata J,Salvato MS,Lukashevich IS

    更新日期：2007-05-16 00:00:00

  • Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine.

    abstract：BACKGROUND:In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys. METHODS:The cultures of SARS coronavirus (SARS-CoV) BJ-01 strain infected Vero cells we...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.06.038

    authors： Qin E,Shi H,Tang L,Wang C,Chang G,Ding Z,Zhao K,Wang J,Chen Z,Yu M,Si B,Liu J,Wu D,Cheng X,Yang B,Peng W,Meng Q,Liu B,Han W,Yin X,Duan H,Zhan D,Tian L,Li S,Wu J,Tan G,Li Y,Li Y,Liu Y,Liu H,Lv F

    更新日期：2006-02-13 00:00:00

  • Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus.

    abstract：:With the aim of studying the molecular diversity of the antigens of a new recombinant vaccine against meningococcus serogroup B, the three genes coding for the main vaccine components GNA (Genome-derived Neisseria Antigen) 1870 (fHbp, factor H Binding Protein), GNA1994 (NadA, Neisseria adhesin A) and GNA2132 were sequ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.02.098

    authors： Bambini S,Muzzi A,Olcen P,Rappuoli R,Pizza M,Comanducci M

    更新日期：2009-05-11 00:00:00

  • Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens.

    abstract：:The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulati...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.06.036

    authors： Haq K,Abdul-Careem MF,Shanmuganthan S,Thanthrige-Don N,Read LR,Sharif S

    更新日期：2010-08-02 00:00:00

  • Vero-cell rabies vaccine produced using serum-free medium.

    abstract：:A new rabies vaccine was developed from Vero cells adhered to microcarriers, cultivated in a bioreactor in serum-free medium and infected with the PV/VERO-Paris rabies virus strain. The viral suspensions were concentrated by tangential filtration, purified by chromatography and inactivated with beta-propiolactone. In ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.06.014

    authors： Frazatti-Gallina NM,Mourão-Fuches RM,Paoli RL,Silva ML,Miyaki C,Valentini EJ,Raw I,Higashi HG

    更新日期：2004-12-09 00:00:00

  • Studies on the usefulness of intranasal inactivated influenza vaccines.

    abstract：:Intranasal inactivated influenza vaccines have the advantage over parenteral vaccines in that they are not associated with the pain of an injection. However, they would be most useful if they were available for all age groups, including high-risk groups, and also would provide cross-protection against variant virus st...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2010.05.019

    authors： Tamura S

    更新日期：2010-08-31 00:00:00

  • Overview of rabies post-exposure prophylaxis access, procurement and distribution in selected countries in Asia and Africa, 2017-2018.

    abstract：BACKGROUND:Rabies is a neglected zoonotic disease with a global burden of approximately 59,000 human deaths a year. Once clinical symptoms appear, rabies is almost invariably fatal; however, with timely and appropriate post-exposure prophylaxis (PEP) consisting of wound washing, vaccine, and in some cases rabies immuno...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2019.04.024

    authors： Sreenivasan N,Li A,Shiferaw M,Tran CH,Wallace R,Blanton J,Knopf L,Abela-Ridder B,Hyde T,Working group on Rabies PEP logistics.

    更新日期：2019-10-03 00:00:00

  • Brief education to promote maternal influenza vaccine uptake: A randomized controlled trial.

    abstract：BACKGROUND:Although pregnant women are the highest priority group for seasonal influenza vaccination, maternal influenza vaccination rates remain suboptimal. The purpose of this study was to evaluate the effect of a brief education intervention on maternal influenza vaccine uptake. METHODS:During the 2013-14 and 2014-...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2016.09.019

    authors： Wong VWY,Fong DYT,Lok KYW,Wong JYH,Sing C,Choi AY,Yuen CYS,Tarrant M

    更新日期：2016-10-17 00:00:00

  • Process development for the mass production of Ehrlichia ruminantium.

    abstract：:This work describes the optimization of a cost-effective process for the production of an inactivated bacterial vaccine against heartwater and the first attempt to produce the causative agent of this disease, the rickettsia Ehrlichia ruminantium (ER), using stirred tanks. In vitro, it is possible to produce ER using c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.08.109

    authors： Marcelino I,Sousa MF,Veríssimo C,Cunha AE,Carrondo MJ,Alves PM

    更新日期：2006-03-06 00:00:00

  • Molecular epidemiology of tick-borne encephalitis virus: cross-protection between European and Far Eastern subtypes.

    abstract：:Tick-borne encephalitis virus isolates from widely separated geographic regions of the USSR, six isolates from Hungary and one from France were compared with the European and Far Eastern prototype viruses. Peptide mapping by limited proteolysis yielded similar patterns for five selected isolates from the USSR. All iso...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90376-u

    authors： Holzmann H,Vorobyova MS,Ladyzhenskaya IP,Ferenczi E,Kundi M,Kunz C,Heinz FX

    更新日期：1992-01-01 00:00:00

  • Health and economic benefits of single-dose HPV vaccination in a Gavi-eligible country.

    abstract：BACKGROUND:Although guidelines for prophylactic human papillomavirus (HPV) vaccination recommend two doses for girls ages 9-14 years, several studies have demonstrated similar protection with one dose. Our objective was to evaluate the long-term health and economic impacts of routine one-dose HPV vaccination compared t...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.04.061

    authors： Burger EA,Campos NG,Sy S,Regan C,Kim JJ

    更新日期：2018-08-06 00:00:00

  • Vaccines and Internet: characteristics of the vaccine safety net web sites and suggested improvements.

    abstract：UNLABELLED:The Internet contains a large amount of useful information on many subjects, but also information of doubtful quality. To help identify Web sites on vaccine safety that fulfil good practice, the Global Advisory Committee on Vaccine Safety of the World Health Organization (WHO) has published criteria to which...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.09.093

    authors： Martínez-Mora M,Alvarez-Pasquín MJ,Rodríguez-Salvanés F

    更新日期：2008-12-09 00:00:00