Abstract：
:Nearly half of the proteins in the complement system serve in regulation. Control at the central step of C3 activation is provided by an orchestrated interplay of membrane and plasma regulators. A model system employing Chinese hamster ovary (CHO) cells transfected with human regulators was employed to assist in making functional comparisons. Also, in this experimental setup, the pathway and magnitude of complement activation can be varied while monitoring C4b/C3b deposition and cleavage as well as cytotoxicity. This review describes lessons learned and the application of this model for functionally characterizing mutations in regulators associated with atypical hemolytic uremic syndrome.
journal_name
Vaccinejournal_title
Vaccineauthors
Liszewski MK,Fang CJ,Atkinson JPdoi
10.1016/j.vaccine.2008.11.001subject
Has Abstractpub_date
2008-12-30 00:00:00pages
I22-7eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)01508-9journal_volume
26 Suppl 8pub_type
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