Abstract：
:Vibrio cholerae O139 Bengal strain was the causative agent of the recent epidemics of cholera in India and Bangladesh. We studied antibacterial and antitoxin immune responses in acute and convalescent phase paired sera collected from seven of these cholera patients. Significant rise in the levels of both antibacterial and antitoxin antibodies was demonstrable in the sera of convalescent cholera patients. Antibacterial antibodies, directed primarily against O139 lipopolysaccharides (LPS), belonged to IgM class, while antitoxin antibodies were of IgG and IgA class and neutralized cholera toxin. The convalescent sera, however, showed no increase in the reactivity towards V. cholerae O1 whole cells or their LPS preparation. Immunoblotting experiments revealed that the convalescent, but not the acute, phase serum recognized the truncated form of LPS characteristics of O139 strains. Convalescent serum also induced definite protection against O139, but not O1, challenge in experimental animal model. Further studies showed that such protection was probably mediated by antibodies inhibiting intestinal colonization of O139 organisms. These results suggest that critical difference(s) exists between the immunogenic somatic components of V. cholerae O1 and O139 organisms that are of considerable importance in protection against cholera.
journal_name
Vaccinejournal_title
Vaccineauthors
Nandy RK,Albert MJ,Ghose ACdoi
10.1016/0264-410x(96)00035-7subject
Has Abstractpub_date
1996-08-01 00:00:00pages
1137-42issue
12eissn
0264-410Xissn
1873-2518pii
0264410X96000357journal_volume
14pub_type
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