Abstract:
:One hundred healthy Caucasian medical students (age 22 +/- 1 years) were vaccinated with a recombinant hepatitis B vaccine and their haptoglobin types were determined. A relationship between haptoglobin type and immune response to the vaccine was observed. Subjects with a 2-2 haptoglobin phenotype produced significantly lower hepatitis B antibody titres than those having a 1-1 or 2-1 haptoglobin phenotype. The haptoglobin phenotypes not only influenced the magnitude but also the kinetics of the anti-HBs response. For all haptoglobin types, haptoglobin concentration and immune response to the vaccine behaved independently.
journal_name
Vaccinejournal_title
Vaccineauthors
Louagie H,Delanghe J,Desombere I,De Buyzere M,Hauser P,Leroux-Roels Gdoi
10.1016/0264-410x(93)90041-usubject
Has Abstractpub_date
1993-09-01 00:00:00pages
1188-90issue
12eissn
0264-410Xissn
1873-2518pii
0264-410X(93)90041-Ujournal_volume
11pub_type
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