Haptoglobin polymorphism and the immune response after hepatitis B vaccination.

Abstract:

:One hundred healthy Caucasian medical students (age 22 +/- 1 years) were vaccinated with a recombinant hepatitis B vaccine and their haptoglobin types were determined. A relationship between haptoglobin type and immune response to the vaccine was observed. Subjects with a 2-2 haptoglobin phenotype produced significantly lower hepatitis B antibody titres than those having a 1-1 or 2-1 haptoglobin phenotype. The haptoglobin phenotypes not only influenced the magnitude but also the kinetics of the anti-HBs response. For all haptoglobin types, haptoglobin concentration and immune response to the vaccine behaved independently.

journal_name

Vaccine

journal_title

Vaccine

authors

Louagie H,Delanghe J,Desombere I,De Buyzere M,Hauser P,Leroux-Roels G

doi

10.1016/0264-410x(93)90041-u

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

1188-90

issue

12

eissn

0264-410X

issn

1873-2518

pii

0264-410X(93)90041-U

journal_volume

11

pub_type

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