Comparative safety study of three inactivated BTV-8 vaccines in sheep and cattle under field conditions.

abstract：BACKGROUND:India has faced considerable challenges in eradicating polio. Uttar Pradesh (UP) and Bihar are the two states in India where transmission of polio has never been interrupted. Private pediatricians are important stakeholders for vaccine delivery and maintaining public confidence in vaccines. The purpose of th...

journal_title：Vaccine

authors： Choudhury P,Thacker N,Gargano LM,Weiss PS,Vashishtha VM,Amladi T,Pazol K,Orenstein WA,Omer SB,Hughes JM

更新日期：2011-10-26 00:00:00

abstract：:Outer membrane protein (OMP) vaccines are being developed against Neisseria meningitidis serogroup B which may provide protection against common circulating serotypes and serosubtypes in some countries. However, limited data is available in Europe from genosubtyping meningococci. We therefore undertook a retrospective...

journal_title：Vaccine

authors： Clarke SC,Diggle MA,Mölling P,Unemo M,Olcén P

更新日期：2003-06-02 00:00:00

abstract：:Plasmodium vivax is responsible for an approximate 35 million yearly human cases of malaria. Unfortunately, due to the low mortality rate associated with it and the difficulties of continuously in vitro culturing of this parasite, vaccine development against this human malaria has been largely neglected. In here, the ...

journal_title：Vaccine

authors： de Oliveira CI,Wunderlich G,Levitus G,Soares IS,Rodrigues MM,Tsuji M,del Portillo HA

更新日期：1999-08-06 00:00:00

abstract：:This work describes the nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various ligands capable of triggering individual TLRs, and then focuses on the efficacy and safety of those agents for which clinical results ar...

journal_title：Vaccine

authors： Steinhagen F,Kinjo T,Bode C,Klinman DM

更新日期：2011-04-12 00:00:00

abstract：:A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protect...

journal_title：Vaccine

authors： Tang LH,Lim JH,Kuah LF,Lau YF

更新日期：2014-09-22 00:00:00

abstract：BACKGROUND:Vaccinations are an effective choice to stop disease outbreaks, including COVID-19. There is little research on individuals' COVID-19 vaccination decision-making. OBJECTIVE:We aimed to determine individual preferences for COVID-19 vaccinations in China, and to assess the factors influencing vaccination deci...

journal_title：Vaccine

authors： Leng A,Maitland E,Wang S,Nicholas S,Liu R,Wang J

更新日期：2021-01-08 00:00:00

abstract：:Experimental whole-parasite immunization through concurrent administration of infectious Plasmodium sporozoites with drugs that prevent pathogenic blood-stage infection represents the current benchmark in malaria vaccine development. Key questions concerning translation remain, including the requirement for single-dos...

journal_title：Vaccine

authors： Pfeil J,Sepp KJ,Heiss K,Meister M,Mueller AK,Borrmann S

更新日期：2014-10-14 00:00:00

abstract：:Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1-polarizing adjuvan...

journal_title：Vaccine

authors： Orbegozo-Medina RA,Martínez-Sernández V,González-Warleta M,Castro-Hermida JA,Mezo M,Ubeira FM

更新日期：2018-04-05 00:00:00

abstract：:Iscoms, with rCTB incorporated via the GM1 receptor, enhanced in mice the mucosal immunogenicity of rCTB as antigen after intranasal (i.n.) administration both by inducing IgA response in the remote intestinal tract mucosa and by a 100-fold increase of the specific IgA locally in the lungs. Iscom-matrix as a separate ...

journal_title：Vaccine

authors： Ekström J,Hu KF,Bengtsson KL,Morein B

更新日期：1999-06-04 00:00:00

abstract：:Safety of individuals at risk of immune suppression is an important concern for live vaccines. The new-generation tuberculosis vaccine candidate MTBVAC, a genetically engineered doubly attenuated Mycobacterium tuberculosis mutant with deletions in phoP and fadD26 virulence genes has demonstrated comparable safety in d...

journal_title：Vaccine

authors： Solans L,Uranga S,Aguilo N,Arnal C,Gomez AB,Monzon M,Badiola JJ,Gicquel B,Martin C

更新日期：2014-09-08 00:00:00

abstract：PURPOSE:Human Papillomavirus (HPV) vaccine uptake remains low. Although publicly funded programs provide free or low cost vaccines to low-income children, barriers aside from cost may prevent disadvantaged girls from getting vaccinated. Prior studies have shown distance to health care as a potential barrier to utilizin...

journal_title：Vaccine

authors： Tsui J,Singhal R,Rodriguez HP,Gee GC,Glenn BA,Bastani R

更新日期：2013-04-12 00:00:00

abstract：:Ten prospective clinical trials conducted in elderly and high-risk adults have failed to show that pneumococcal vaccine prevents pneumococcal bacteraemia and all pneumonia. Several of these trials focused on unrepresentative populations and most had serious methodological problems. Few adequately considered sample siz...

journal_title：Vaccine

authors： Fedson DS,Liss C

更新日期：2004-02-25 00:00:00

abstract：:Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenici...

journal_title：Vaccine

authors： Villa LL,Ault KA,Giuliano AR,Costa RL,Petta CA,Andrade RP,Brown DR,Ferenczy A,Harper DM,Koutsky LA,Kurman RJ,Lehtinen M,Malm C,Olsson SE,Ronnett BM,Skjeldestad FE,Steinwall M,Stoler MH,Wheeler CM,Taddeo FJ,Yu J,

更新日期：2006-07-07 00:00:00

abstract：:The identification of new vaccine candidates for leptospirosis is of great interest. This paper describes the identification of two homologous immunogenic proteins, LigA-m and LigB-m, of Leptospira interrogans serovar manilae strain UP-MMC-NIID, which show strong similarity with LigA found recently in L. interrogans s...

journal_title：Vaccine

authors： Koizumi N,Watanabe H

更新日期：2004-03-29 00:00:00

abstract：:The purpose of the present research work is to explore the potential of dendrosomes in genetic immunization against hepatitis B. Plasmid DNA encoding pRc/CMV-HBs[S] (5.6 kb), encoding the small region of the hepatitis B surface antigen, was complexed with 5th generation poly(propyleneimine) dendrimer (PPI) in differen...

journal_title：Vaccine

authors： Dutta T,Garg M,Jain NK

更新日期：2008-06-25 00:00:00

abstract：BACKGROUND:Cross-clade immunogenic stockpiled H5N1 vaccines may decrease the morbidity and transmission of infection during the initial phase of influenza pandemic. Meta-analysis of cross-reactive antibodies induced by oil-in-water emulsion adjuvanted (OWEA) influenza H5N1 virus monovalent vaccines with circulating het...

journal_title：Vaccine

authors： Chada KE,Forshee R,Golding H,Anderson S,Yang H

更新日期：2017-05-31 00:00:00

abstract：:Fertile turkey eggs after 24 days of incubation were vaccinated in ovo with a commercial live attenuated subtype A avian pneumovirus (APV) vaccine. Hatchability was not adversely affected. When a high dose (10 times maximum commercial dose) of vaccine was tested in maternal antibody negative (MA-) eggs, mild clinical ...

journal_title：Vaccine

authors： Worthington KJ,Sargent BA,Davelaar FG,Jones RC

更新日期：2003-03-28 00:00:00

abstract：:Recombinant hepatitis B surface antigen (HBsAg) particles derived from Chinese hamster ovary (CHO) cells were stored at various conditions for 12-18 months in their naked form or adsorbed to alum (HBV vaccine). The physical, chemical and immunological parameters during storage at -20 degrees C, 4 degrees C, room tempe...

journal_title：Vaccine

authors： Diminsky D,Moav N,Gorecki M,Barenholz Y

更新日期：1999-08-20 00:00:00

abstract：:Dengue is a significant threat to public health worldwide. Currently, there are no licensed vaccines available for dengue. Takeda Vaccines Inc. is developing a live, attenuated tetravalent dengue vaccine candidate (TDV) that consists of an attenuated DENV-2 strain (TDV-2) and three chimeric viruses containing the prM ...

journal_title：Vaccine

authors： Osorio JE,Partidos CD,Wallace D,Stinchcomb DT

更新日期：2015-12-10 00:00:00

abstract：:Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replicatio...

journal_title：Vaccine

authors： James CM,Abdad MY,Mansfield JP,Jacobsen HK,Vind AR,Stumbles PA,Bartlett EJ

更新日期：2007-02-26 00:00:00

abstract：:In March 2010, Brazil introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in the routine infant immunization program using a 4-dose schedule and catch-up for children <23months. We investigated PCV10 effect on nasopharyngeal carriage with vaccine-type Streptococcus pneumoniae (Spn) and non-typeable Haemoph...

journal_title：Vaccine

authors： Brandileone MC,Zanella RC,Almeida SCG,Brandao AP,Ribeiro AF,Carvalhanas TMP,Sato H,Andrade AL,Verani JR,Pneumococcal Carriage Study Group.

更新日期：2016-11-04 00:00:00

abstract：:Through the specific and tight interaction between streptavidin and biotin, a novel platform was developed to allow for rapid (less than 2h), efficient and durable display of streptavidin-tagged bioactive GM-CSF on the surface of biotinylated B16.F10 tumor cells. This technology involved biotinylation of the cell memb...

journal_title：Vaccine

authors： Gao J,Huang S,Li M,Luo R,Wang X,Takashima A

更新日期：2006-06-19 00:00:00

abstract：:Cytotoxic T cells are the main antigen-specific effector cells of the cellular immune system and MHC class I restricted cytotoxic T-lymphocyte (CTL) responses in mice, acting against the HIV-1 envelope protein, are known to be predominantly directed against an amino acid sequence in the third hypervariable domain. We ...

journal_title：Vaccine

authors： Achour A,Picard O,Mbika JP,Willer A,Snart R,Bizzini B,Carelli C,Burny A,Zagury D

更新日期：1993-01-01 00:00:00

abstract：:Ticks (Acari: Ixodidae) are considered to be the most important vectors of disease-causing pathogens in domestic and wild animals, and emerging and re-emerging tick-borne diseases (TBD) exert an enormous impact on them. Wild ungulates are hosts for a wide variety of tick species and tick-borne pathogens that affect hu...

journal_title：Vaccine

authors： Contreras M,San José C,Estrada-Peña A,Talavera V,Rayas E,Isabel León C,Luis Núñez J,García Fernández de Mera I,de la Fuente J

更新日期：2020-09-22 00:00:00

abstract：:The critical first step in the clinical development of a malaria vaccine, based on live-attenuated Plasmodium falciparum sporozoites, is the guarantee of complete arrest in the liver. We report on an approach for assessing adequacy of attenuation of genetically attenuated sporozoites in vivo using the Plasmodium bergh...

journal_title：Vaccine

authors： Annoura T,Ploemen IH,van Schaijk BC,Sajid M,Vos MW,van Gemert GJ,Chevalley-Maurel S,Franke-Fayard BM,Hermsen CC,Gego A,Franetich JF,Mazier D,Hoffman SL,Janse CJ,Sauerwein RW,Khan SM

更新日期：2012-03-30 00:00:00

abstract：:The emergence of lineage 2 strains of WNV in Europe as a cause of clinical disease and mortality in horses raised the question whether the existing WNV vaccines, all based on lineage 1 strains, protect against circulating lineage 2 strains of WNV. In the present paper we have determined the level of cross protection p...

journal_title：Vaccine

authors： Minke JM,Siger L,Cupillard L,Powers B,Bakonyi T,Boyum S,Nowotny N,Bowen R

更新日期：2011-06-20 00:00:00

abstract：:After the publication of case reports of hepatitis B vaccinees with onset or relapse of multiple sclerosis (MS), followed by a media-driven scare campaign in France, the perception that hepatitis B vaccine causes MS has developed. This has led to a fall in the acceptance of hepatitis B vaccination particularly in Fren...

journal_title：Vaccine

authors： Monteyne P,André FE

更新日期：2000-04-03 00:00:00

abstract：:Since many years Afssaps applies the 3R's strategy (replacement, reduction and refinement) for the use of laboratory animal testing in the framework of vaccine batch release. In this context, for Hepatitis A vaccines, a study was carried out to assess the feasibility of replacing the in vivo "Gold Standard" potency as...

journal_title：Vaccine

authors： Poirier B,Variot P,Delourme P,Maurin J,Morgeaux S

更新日期：2010-02-17 00:00:00

abstract：:Anti-angiogenesis represents an indispensible strategy for cancer therapy. As a strictly endothelial-specific adhesion molecule, vascular endothelial cadherin (VE-cadherin, VE-cad) is a promising anti-angiogenesis target. In this study a recombinant adenovirus vector modified with mannan was used to deliver VE-cad (Ad...

journal_title：Vaccine

authors： Zhao Z,Yao Y,Ding Z,Chen X,Xie K,Luo Y,Zhang J,Chen X,Wu X,Xu J,Zhao J,Niu T,Liu J,Li Q,Zhang W,Wen Y,Su J,Hu B,Bu H,Wei Y,Wu Y

更新日期：2011-06-06 00:00:00

abstract：:Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in about 150,000 individuals in Eurasia, and several hundred cases of hantavirus pulmonary syndrome (HPS) on the American continent annually. There is consequently a need for rapid diagnostics and effective prevention of hantaviral infections. In this stu...

journal_title：Vaccine

authors： Lindkvist M,Lahti K,Lilliehöök B,Holmström A,Ahlm C,Bucht G

更新日期：2007-02-19 00:00:00