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Potential of KM+ lectin in immunization against Leishmania amazonensis infection.

Abstract：

:In the present study we evaluated Canavalia brasiliensis (ConBr), Pisum arvense (PAA) and Artocarpus integrifolia (KM+) lectins as immunostimulatory molecules in vaccination against Leishmania amazonensis infection. Although they induced IFN-gamma production, the combination of the lectins with SLA antigen did not lead to lesion reduction. However, parasite load was largely reduced in mice immunized with KM+ lectin and SLA. KM+ induced a smaller inflammatory reaction in the air pouch model and was able to inhibit differentiation of dendritic cells (BMDC), but to induce maturation by enhancing the expression of MHC II, CD80 and CD86. These observations indicate the modulatory role of plant lectins in leishmaniasis vaccination may be related to their action on the initial innate response.

journal_name

Vaccine

journal_title

Vaccine

authors

Teixeira CR,Cavassani KA,Gomes RB,Teixeira MJ,Roque-Barreira MC,Cavada BS,da Silva JS,Barral A,Barral-Netto M

doi

10.1016/j.vaccine.2005.11.067

subject

Has Abstract

pub_date

2006-04-05 00:00:00

pages

3001-8

issue

15

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)01289-2

journal_volume

24

pub_type

杂志文章

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