Mucosal inoculation with an attenuated mouse pneumovirus strain protects against virulent challenge in wild type and interferon-gamma receptor deficient mice.

abstract：BACKGROUND:To block transmission of measles, the China Ministry of Health endorsed the "2006-2012 National Measles Elimination Action Plan (NMEAP)" on November 11, 2006, while no published studies used mathematical models to assess the impact of this action. Also, the problem of residuals autocorrelation due to auto-co...

journal_title：Vaccine

authors： Xu L,Chen J,Zhan Z,Chen T,Liu W,Qian J,Ou C

更新日期：2020-06-09 00:00:00

abstract：:Since the introduction to the Swiss market in 1997, Crucell (former Berna Biotech Ltd.), has sold over 41 million doses worldwide of the virosomal adjuvanted influenza vaccine, Inflexal V. Since 1992, 29 company sponsored clinical studies investigating the efficacy and safety of Inflexal V have been completed in which...

journal_title：Vaccine

authors： Herzog C,Hartmann K,Künzi V,Kürsteiner O,Mischler R,Lazar H,Glück R

更新日期：2009-07-16 00:00:00

abstract：:Hepatitis B is a parenterally and sexually transmitted disease of global importance. It associates with hepatitis D in a consistent proportion of cases. The disease most frequently runs a subclinical and anicteric course, with a significant number of cases that become chronic. Chronic hepatitis may progress to cirrhos...

journal_title：Vaccine

authors： Nisini R,Rizzetto M

更新日期：1993-01-01 00:00:00

abstract：:The aim of the study was to compare the responses of homosexual men (HM) receiving a standard course of recombinant hepatitis B vaccine with those of healthcare workers vaccinated in the same hospital over the same period. Boosters for inadequate responders and repeat courses for non-responders were given. Forty of 61...

journal_title：Vaccine

authors： Das S,Brassington M,Drake SM,Boxall E

更新日期：2003-09-08 00:00:00

abstract：BACKGROUND:Haemophilus influenzae type b (Hib) conjugate vaccines have significantly limited Hib's disease impact in every country where it was introduced. We previously estimated invasive Hib disease incidence in Singapore at ∼4.4 per 100,000 children <5 years (from 1994 to 2003, period 1), but the vaccine was not inc...

journal_title：Vaccine

authors： Thoon KC,Tee NW,Chew L,Chong CY

更新日期：2014-10-07 00:00:00

abstract：:Humoral responses against extra-cellular HIV-1 Tat may be beneficial as Tat has been implicated in the viral pathogenesis associated with HIV-1 disease progression. We determined the levels of anti-Tat IgG in sera of HIV-1 seropositive individuals from the Rural Clinical Cohort in Uganda using nine different Tat prote...

journal_title：Vaccine

authors： Campbell GR,Senkaali D,Watkins J,Esquieu D,Opi S,Yirrell DL,Kaleebu P,Loret EP

更新日期：2007-12-05 00:00:00

abstract：:The safety and immunogenicity of two PorA-based meningococcal outer membrane vesicle (OMV) vaccines against the P1.4 serosubtype adsorbed with AlPO(4) or Al(OH)(3) were studied in 134 toddlers. Vaccinations were given three times with an interval of 3-6 weeks or twice with an interval of 6-10 weeks. A vaccination was ...

journal_title：Vaccine

authors： de Kleijn ED,de Groot R,Lafeber AB,Labadie J,van Limpt KC,Visser J,Berbers GA,van Alphen L,Rümke HC

更新日期：2000-12-08 00:00:00

abstract：:In the present study, cross-protection to bovine herpesvirus type 5 (BHV-5) induced by bovine herpesvirus type 1 (BHV-1) vaccination was examined following inoculation of rabbits and calves with a glycoprotein E (gE)-negative BHV-1 vaccine and subsequent challenge with BHV-5. Rabbits (n=5) and calves (n=8) were vaccin...

journal_title：Vaccine

authors： Silva AD,Spilki FR,Franco AC,Esteves PA,Hübner SO,Driemeier D,Oliveira AP,Rijsewijk F,Roehe PM

更新日期：2006-04-12 00:00:00

abstract：INTRODUCTION:Streptococcus pneumoniae is a capsulated bacterium that can cause severe infection in patients with thalassemia major, particularly those who have undergone splenectomy. The absence of the spleen as well as zinc deficiency in splenectomized patients with thalassemia major increases the possibility of devel...

journal_title：Vaccine

authors： Sari TT,Akib AAP,Gatot D,Roswita Harahap A,Bardosono S,Hadinegoro SRS

更新日期：2017-08-16 00:00:00

abstract：:We previously demonstrated that recombinant raccoonpox (RCN) virus could serve as a vector for an influenza vaccine. RCN constructs expressing the hemagglutinin (HA) from H5N1 viruses were immunogenic in chickens. In the current study, we generated several recombinant RCN constructs expressing influenza (H5N1) antigen...

journal_title：Vaccine

authors： Kingstad-Bakke B,Brewoo JN,Mai le Q,Kawaoka Y,Osorio JE

更新日期：2012-10-05 00:00:00

abstract：:Staphylococci have become the most common causes of nosocomial bacterial infections, and this fact, along with increasing problems associated with antimicrobial resistance, spurs the need for finding immunotherapeutic alternatives to prevent and possibly treat these infections. Most virulent, clinical isolates of both...

journal_title：Vaccine

authors： Maira-Litran T,Kropec A,Goldmann D,Pier GB

更新日期：2004-02-17 00:00:00

abstract：:Protopanaxadiol saponins (Rg3, Rd, Rc, Rb1 and Rb2) and protopanaxatriol saponins (Rg1, Re and Rg2) isolated from the root of Panax ginseng C.A. Meyer were evaluated for their adjuvant effects on the immune responses to ovalbumin (OVA) in mice. BALB/c mice were subcutaneously injected twice at a 3-week interval with 1...

journal_title：Vaccine

authors： Sun J,Hu S,Song X

更新日期：2007-01-22 00:00:00

abstract：:After decades of inconsequential infections, and sporadic outbreaks in the Asia-Pacific region between 2007 and 2013, Zika virus caused a widespread epidemic in South America in 2015 that was complicated by severe congenital infections. After the WHO declared a Public Health Emergency of International Concern in Febru...

journal_title：Vaccine

authors： Lecouturier V,Bernard MC,Berry C,Carayol S,Richier E,Boudet F,Heinrichs J

更新日期：2019-05-06 00:00:00

abstract：:The ability to protect mice against respiratory infections with virulent Francisella tularensis has been problematic and the role of antibody-versus-cell-mediated immunity controversial. In this study, we tested the hypothesis that protective immunity can develop in mice that were given antibiotic therapy following in...

journal_title：Vaccine

authors： Klimpel GR,Eaves-Pyles T,Moen ST,Taormina J,Peterson JW,Chopra AK,Niesel DW,Carness P,Haithcoat JL,Kirtley M,Nasr AB

更新日期：2008-12-09 00:00:00

abstract：:MAGE-A3 is highly expressed in epithelial ovarian cancer (EOC), making it a promising candidate for immunotherapy. We investigated whether dendritic cells (DCs) transduced with a rAAV-6 capsid mutant vector Y445F could elicit effective MAGE-A3-specific anti-tumor cytotoxic T lymphocyte (CTL) responses in vitro. MAGE-A...

journal_title：Vaccine

authors： Batchu RB,Gruzdyn OV,Moreno-Bost AM,Szmania S,Jayandharan G,Srivastava A,Kolli BK,Weaver DW,van Rhee F,Gruber SA

更新日期：2014-02-12 00:00:00

abstract：:Varied doses of Taishan Pinus massoniana pollen polysaccharide (TPPPS) and Astragalus polysaccharide (APS) extracted by hot water extraction and ethanol precipitation method were added to the vaccine in order to prepare polysaccharide-rabbit haemorrhagic disease (RHD) tissue inactivated vaccine. The purpose was to stu...

journal_title：Vaccine

authors： Wei K,Sun Z,Yan Z,Tan Y,Wang H,Zhu X,Wang X,Sheng P,Zhu R

更新日期：2011-03-21 00:00:00

abstract：:An effective vaccination strategy against human immunodeficiency virus type 1 (HIV-1) should include the induction of potent cellular immune responses against conserved HIV-1 antigens. We have generated five replication competent recombinant influenza viruses (rFlu/SIV Gag nos. 1-5) expressing different portions of Ga...

journal_title：Vaccine

authors： Nakaya Y,Zheng H,García-Sastre A

更新日期：2003-05-16 00:00:00

abstract：INTRODUCTION:Immunization education for physicians-in-training is crucial to address vaccine concerns in clinical practice. Vaccine education is not standardized across residency programs. The Collaboration for Vaccination Education and Research (CoVER) team developed an online curriculum for pediatric (Peds) and famil...

journal_title：Vaccine

authors： Pahud B,Elizabeth Williams S,Lee BR,Lewis KO,Middleton DB,Clark S,Humiston SG

更新日期：2020-10-27 00:00:00

abstract：:To evaluate the safety and immunogenicity of a diphtheria, tetanus, acellular pertussis and Haemophilus infuenzae Type b (DTaP/Hib) combination vaccine first developed by a Chinese manufacturer, a randomized, two-stage, parallel controlled, single center clinical trial was conducted in Dafeng, Jiangsu Province of Chin...

journal_title：Vaccine

authors： Li G,Zhang H,Zhou W,Ye Q,Li F,Wang H,Hou Q,Xu Y,Ma X,Tan Y,Wang L,Li Y,Li H,Meng F,Liang Q,Liu A,Qin C,Wei W,Liu J,Ruan C,Tao W,Zhang S,Zheng H,Zhu F

更新日期：2010-06-07 00:00:00

abstract：:This study examines the potential clinical and economic benefits for adults arising from paediatric pneumococcal vaccination in the UK. A UK birth cohort model with a 10-year horizon and using a primary 4-dose paediatric 7-valent pneumococcal conjugate vaccine (PCV) schedule was populated with 1999 morbidity and morta...

journal_title：Vaccine

authors： McIntosh ED,Conway P,Willingham J,Hollingsworth R,Lloyd A

更新日期：2005-02-25 00:00:00

abstract：:After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the infant national immunization program (NIP) in the Netherlands in 2006, Streptococcus pneumoniae strains of the non-vaccine serotype 19A emerged and became the dominant serotype in carriage in children and their parents. Similar patterns we...

journal_title：Vaccine

authors： Bosch AATM,van Houten MA,Bruin JP,Wijmenga-Monsuur AJ,Trzciński K,Bogaert D,Rots NY,Sanders EAM

更新日期：2016-01-20 00:00:00

abstract：:FHbp is a major serogroup B meningococcal vaccine antigen. Binding of complement Factor H (FH) to FHbp is specific for human and some non-human primate FH. In previous studies, FH binding to FHbp vaccines impaired protective anti-FHbp antibody responses. In this study we investigated anti-FHbp antibody responses to a ...

journal_title：Vaccine

authors： Giuntini S,Beernink PT,Granoff DM

更新日期：2015-12-16 00:00:00

abstract：:Mucin1 (MUC1) is expressed ubiquitously on breast cancer cells and is a potential target for the generation of cytotoxic T cells for vaccination against breast cancer. Thus far studies of the immunogenicity of MUC1 have used peptides from the variable number of tandem repeat (VNTR); mice so immunised can generate stro...

journal_title：Vaccine

authors： Pietersz GA,Li W,Osinski C,Apostolopoulos V,McKenzie IF

更新日期：2000-04-03 00:00:00

abstract：:Rotavirus (RV) is the primary etiologic agent of severe gastroenteritis in human infants. Although two attenuated RV-based vaccines have been licensed to be applied worldwide, they are not so effective in low-income countries, and the induced protection mechanisms have not been clearly established. Thus, it is importa...

journal_title：Vaccine

authors： Badillo-Godinez O,Gutierrez-Xicotencatl L,Plett-Torres T,Pedroza-Saavedra A,Gonzalez-Jaimes A,Chihu-Amparan L,Maldonado-Gama M,Espino-Solis G,Bonifaz LC,Esquivel-Guadarrama F

更新日期：2015-08-20 00:00:00

abstract：:Because of the serious economic and medical consequences of brucellosis, efforts are to prevent infection of domestic animals through vaccines. Many disadvantages are associated with the current Brucella melitensis Rev.1 vaccine prompting development of alternative vaccines and delivery. Escherichia coli (DH5α) was en...

journal_title：Vaccine

authors： Gupta VK,Radhakrishnan G,Harms J,Splitter G

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Protein-polysaccharide conjugate vaccines such as Haemophilus influenzae type b (Hib), meningococcal, and pneumococcal vaccine, induce immunological memory and longer lasting protection than plain polysaccharide vaccines. The most common proteins used as carriers are tetanus toxoid (TT) and cross reacting ma...

journal_title：Vaccine

authors： Voysey M,Sadarangani M,Clutterbuck E,Bolgiano B,Pollard AJ

更新日期：2016-07-25 00:00:00

abstract：:DNA vaccination is particularly efficient for induction of cytotoxic T-lymphocyte (CTL) response. In our experiments, we used MHC(B) congenic chicken lines CB and CC (regressors and progressors of v-src-induced tumours, respectively) and a mutated, non-oncogenic v-src gene construct as the DNA vaccine. A high degree o...

journal_title：Vaccine

authors： Plachý JV,Hejnar JV,Trtková K,Trejbalová K,Svoboda J,Hála K

更新日期：2001-08-14 00:00:00

abstract：:The adjuvant properties of polyglucosamine/squalene-based nanocapsules (PG-nanocapsules) associated with different subunit antigens has been previously reported. Thus, the aim of the present study was to monitor the biodistribution of PG-nanocapsules and their affinity for the draining lymph nodes after subcutaneous (...

journal_title：Vaccine

authors： Vicente S,Goins BA,Sanchez A,Alonso MJ,Phillips WT

更新日期：2014-03-26 00:00:00

abstract：:The induction of antigen specific memory CD8(+) T cells in vivo is very important to new vaccines against infectious diseases. In the present study, we aimed to evaluate the immune responses of peptide-specific CD8(+) T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SA...

journal_title：Vaccine

authors： Zhao K,Wang H,Wu C

更新日期：2011-09-02 00:00:00

abstract：:To date, most peptide-based vaccines evaluated for the treatment of cancer have consisted of one or few peptides. However, as a greater number of peptide antigens become available for use in experimental therapies, it is important to establish the feasibility of combining multi-peptide reagents as individual peptide m...

journal_title：Vaccine

authors： Chianese-Bullock KA,Lewis ST,Sherman NE,Shannon JD,Slingluff CL Jr

更新日期：2009-03-10 00:00:00