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Tat mutations in an African cohort that do not prevent transactivation but change its immunogenic properties.

Abstract：

:Humoral responses against extra-cellular HIV-1 Tat may be beneficial as Tat has been implicated in the viral pathogenesis associated with HIV-1 disease progression. We determined the levels of anti-Tat IgG in sera of HIV-1 seropositive individuals from the Rural Clinical Cohort in Uganda using nine different Tat proteins representative of the major subtypes presently accounting for 97% of infections worldwide. We observed the presence of anti-Tat IgG able to react against the various subtypes tested, although none cross-reacted against all nine variants. We show that 46.25% of seropositive patients were able to recognise at least one Tat variant with 1:1000 sera dilution. We also show that the C terminus of Tat is the most variable region and an important epitope that might explain the limitation of cross-recognition of Tat antibodies regarding Tat variants. This study shows in seropositive patients that Tat can tolerate mutations without modification of its primary function but with changes in its immunogenic properties. These findings should be considered when designing Tat-based HIV-1 vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Campbell GR,Senkaali D,Watkins J,Esquieu D,Opi S,Yirrell DL,Kaleebu P,Loret EP

doi

10.1016/j.vaccine.2007.09.070

subject

Has Abstract

pub_date

2007-12-05 00:00:00

pages

8441-7

issue

50

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)01092-4

journal_volume

25

pub_type

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