Secondary in vitro B lymphocyte (antibody) response to microbial antigens: use in appraisal of vaccine immunogenicity and cytokine immunoregulation.

Abstract:

:In order to perform preliminary evaluations of subunit vaccine candidates before extensive trials in large food-producing animals, an in vitro B-lymphocyte response assay, based on the principles of an ELISA, was established. The assay was developed in detail for the porcine system using antigens from the Gram-negative bacterium Actinobacillus pleuropneumoniae, but is shown to be applicable to other species and antigens, including viral components. It is further shown that B-cell activity in the assay is dependent on T-helper cells as well as macrophages and/or their secretory products. Thus, in addition to providing a tool for evaluation of T and B memory cell activity, the system also lends itself to dissection of T-B cell collaboration and the regulatory functions of interleukins in secondary (in vitro) antibody responses.

journal_name

Vaccine

journal_title

Vaccine

authors

Ohmann HB,McDougall L,Potter A

doi

10.1016/0264-410x(91)90149-z

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

170-6

issue

3

eissn

0264-410X

issn

1873-2518

pii

0264-410X(91)90149-Z

journal_volume

9

pub_type

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