Secondary in vitro B lymphocyte (antibody) response to microbial antigens: use in appraisal of vaccine immunogenicity and cytokine immunoregulation.

abstract：:To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 microg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 microg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only lo...

journal_title：Vaccine

authors： Couch RB,Winokur P,Brady R,Belshe R,Chen WH,Cate TR,Sigurdardottir B,Hoeper A,Graham IL,Edelman R,He F,Nino D,Capellan J,Ruben FL

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:Observational studies of influenza vaccine effectiveness often study persons seeking medical care for acute respiratory infection (ARI). We conducted a pilot study to determine if vaccine effectiveness could be estimated in the general population with a novel rolling cross-sectional survey sampling design ...

journal_title：Vaccine

authors： Donahue JG,Kieke BA,Szilagy PG,Blumkin AK,Hilgemann D,Flanders WD,Shay DK,Meece J,Gallivan S,Treanor J,Belongia EA

更新日期：2014-11-12 00:00:00

abstract：:Since smallpox eradication by the WHO during the 1980s, potency of new vaccines is compared to vaccines that were used during the eradication campaign. In this work we characterize the tail scarification technique in mice as a model for scarification in humans. Similar to humans, mice develop "clinical take" which is ...

journal_title：Vaccine

authors： Melamed S,Paran N,Katz L,Ben-Nathan D,Israely T,Schneider P,Levin R,Lustig S

更新日期：2007-11-07 00:00:00

abstract：:The efficacy of antibody immunity against Streptococcus pneumoniae stems from the ability of opsonic, serotype (ST)-specific antibodies to pneumococcal capsular polysaccharide (PPS) to facilitate killing of the homologous ST by host phagocytes. However, PPS-specific antibodies have been identified that are protective ...

journal_title：Vaccine

authors： Fabrizio K,Manix C,Tian H,van Rooijen N,Pirofski LA

更新日期：2010-11-03 00:00:00

abstract：:The shelf life and thermal stability of an antifertility vaccine, in which gonadotropin subunits are linked to carriers such as tetanus toxoid and cholera toxin chain B and has successfully completed phase-I clinical trials at five centres in India, was studied. The vaccine adsorbed on alum was stored at three tempera...

journal_title：Vaccine

authors： Alam A,Singh O,Talwar GP

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated a correlation between Clostridium difficile anti-toxin A serum antibodies and protection against symptomatic disease and recurrence. METHODS:A neutralizing monoclonal antibody to C. difficile toxin A (CDA1) developed by MBL and Medarex, Inc. was studied in a phase II, rand...

journal_title：Vaccine

authors： Leav BA,Blair B,Leney M,Knauber M,Reilly C,Lowy I,Gerding DN,Kelly CP,Katchar K,Baxter R,Ambrosino D,Molrine D

更新日期：2010-01-22 00:00:00

abstract：:Effects of cholera toxin B subunits supplemented with 0.1% cholera toxin (CTB*) on systemic IgE antibody responses to ovalbumin (OVA) were examined in BDFI (H-2b/d), Balb/c (H-2d) and C3H (H-2k) mice given OVA intragastrically or intranasally. Two successive doses of OVA intragastrically administered to Balb/c and C3H...

journal_title：Vaccine

authors： Tamura S,Shoji Y,Hasiguchi K,Aizawa C,Kurata T

更新日期：1994-10-01 00:00:00

abstract：:Ticks (Acari: Ixodidae) are considered to be the most important vectors of disease-causing pathogens in domestic and wild animals, and emerging and re-emerging tick-borne diseases (TBD) exert an enormous impact on them. Wild ungulates are hosts for a wide variety of tick species and tick-borne pathogens that affect hu...

journal_title：Vaccine

authors： Contreras M,San José C,Estrada-Peña A,Talavera V,Rayas E,Isabel León C,Luis Núñez J,García Fernández de Mera I,de la Fuente J

更新日期：2020-09-22 00:00:00

abstract：:The aim of current study was to evaluate the prospects of somatostatin DNA vaccine. Two copies of somatostatin (SS) genes were fused with the hepatitis B surface antigen (HBsAg) S gene using genetic engineering methods, the identified recombinant plasmid designated as pcS/2SS was transfected into HeLa cells to detect ...

journal_title：Vaccine

authors： Liang A,Cao S,Han L,Yao Y,Moaeen-Ud-Din M,Yang L

更新日期：2008-06-02 00:00:00

abstract：:Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the e...

journal_title：Vaccine

authors： Kennedy LJ,Lunt M,Barnes A,McElhinney L,Fooks AR,Baxter DN,Ollier WE

更新日期：2007-12-12 00:00:00

abstract：:Typhoid vaccination is recommended in the United States before travel to countries where typhoid fever is endemic, though little information is available on its effectiveness in travelers. We estimated typhoid vaccination effectiveness (VE) by comparing vaccination status in cases of typhoid fever and paratyphoid feve...

journal_title：Vaccine

authors： Mahon BE,Newton AE,Mintz ED

更新日期：2014-06-17 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) from unvaccinated and vaccinated bovine calves were employed to study the alteration of different T-cell subpopulations, functional competence and detection of foot-and-mouth disease virus (FMDV) at different hours post in vitro infection (hpi) with FMDV serotype either O or ...

journal_title：Vaccine

authors： Joshi G,Sharma R,Kakker NK

更新日期：2009-11-12 00:00:00

abstract：:Protein C deletion mutants of West Nile virus (WNV) were evaluated for their potential use as live virus vaccine candidates in vivo. Double and triple mutants carrying small deletions and second-site point mutations, as well as mutants with large deletions of 36 and 37 amino acid residues were tested in a stringent mo...

journal_title：Vaccine

authors： Schlick P,Kofler RM,Schittl B,Taucher C,Nagy E,Meinke A,Mandl CW

更新日期：2010-08-16 00:00:00

abstract：:A new 13-valent conjugated polysaccharide vaccine (PCV13) against Streptococcus pneumoniae infections, which replaced the 7-valent vaccine (PCV7) in the regional immunization programmes for newborns and children who started but not completed the 3 doses schedule of PCV7, is available in Italy since 2010. The opportuni...

journal_title：Vaccine

authors： Boccalini S,Azzari C,Resti M,Valleriani C,Cortimiglia M,Tiscione E,Bechini A,Bonanni P

更新日期：2011-11-28 00:00:00

abstract：:The induction of antigen specific memory CD8(+) T cells in vivo is very important to new vaccines against infectious diseases. In the present study, we aimed to evaluate the immune responses of peptide-specific CD8(+) T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SA...

journal_title：Vaccine

authors： Zhao K,Wang H,Wu C

更新日期：2011-09-02 00:00:00

abstract：:The feasibility of developing a prophylactic vaccine against SARS was assessed by comparing the immune responses elicited by immunizing mice with a recombinant SARS spike glycoprotein (S-protein) formulated with different adjuvants, given by different routes. In both young and aged mice, an intranasal Protollin-formul...

journal_title：Vaccine

authors： Hu MC,Jones T,Kenney RT,Barnard DL,Burt DS,Lowell GH

更新日期：2007-08-21 00:00:00

abstract：:Vaccine hesitancy is increasing and failure to vaccinate is well-recognised in Europe as a contributing factor to outbreaks of infectious diseases. In Lothian and Scotland, low vaccine uptake has been seen in migrants - notably in the Polish group who have arrived since 2004. The recent Vaccine Confidence in European ...

journal_title：Vaccine

authors： Gorman DR,Bielecki K,Willocks LJ,Pollock KG

更新日期：2019-05-06 00:00:00

abstract：BACKGROUND:During the past decade, in the United States, an increasing number of hepatitis B outbreaks have been reported in assisted living facilities (ALFs) as a result of breaches in infection control practices. We evaluated the seroprotection rates conferred by hepatitis B vaccine among older adults during a respon...

journal_title：Vaccine

authors： Tohme RA,Awosika-Olumo D,Nielsen C,Khuwaja S,Scott J,Xing J,Drobeniuc J,Hu DJ,Turner C,Wafeeg T,Sharapov U,Spradling PR

更新日期：2011-11-21 00:00:00

abstract：:Groups of calves (20 per group) were vaccinated subcutaneously with a single dose of BCG Pasteur (6 x 10(4) or 6 x 10(6) colony forming units) and two months later, 15 calves from each group were challenged intratracheally with virulent Mycobacterium bovis. Vaccination with either dose of BCG induced significant prote...

journal_title：Vaccine

authors： Buddle BM,de Lisle GW,Pfeffer A,Aldwell FE

更新日期：1995-08-01 00:00:00

abstract：:These studies were performed to determine the effects of GPI-0100, a semi synthetic Quillaja Saponin analog, formulated with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) on immunity to HSV. SKH-1 hairless mice, used as a model of herpes labialis, inoculated with HSV-1 results in facial lesions, virus replic...

journal_title：Vaccine

authors： Quenelle DC,Collins DJ,Marciani DJ,Kern ER

更新日期：2006-03-06 00:00:00

abstract：:Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a highly contagious and often fatal disease. We have previously reported the construction and characterization of a single gene apxIIC deletion mutant HB04C(-) based on A. pleuropneumoniae serovar 7 which produces ApxII toxin and ApxIV....

journal_title：Vaccine

authors： Liu J,Chen X,Lin L,Tan C,Chen Y,Guo Y,Jin M,Guo A,Bei W,Chen H

更新日期：2007-11-01 00:00:00

abstract：:We evaluated the prevalence and concentration of serum antibodies 18-24 months after primary inoculation with anthrax and botulinum vaccines, and assessed the reactogenicity and immunogenicity of a significantly delayed booster dose of these vaccines. Five hundred and eight male active-duty military personnel received...

journal_title：Vaccine

authors： Pittman PR,Hack D,Mangiafico J,Gibbs P,McKee KT Jr,Friedlander AM,Sjogren MH

更新日期：2002-05-15 00:00:00

abstract：:The smallpox vaccine Vaccinia was successfully used to eradicate smallpox, but although very effective, it was a very reactogenic vaccine and responsible for the deaths of one or two people per million vaccinated. Modified Vaccinia virus Ankara (MVA) is a replication-deficient and attenuated derivative, also used in t...

journal_title：Vaccine

authors： Gilbert SC

更新日期：2013-09-06 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In t...

journal_title：Vaccine

authors： Goetsch L,Plotnicky-Gilquin H,Aubry JP,De-Lys P,Haeuw JF,Bonnefoy JY,Nguyen NT,Corvaïa N,Velin D

更新日期：2001-07-16 00:00:00

abstract：BACKGROUND:High incidence and serotype diversity of invasive pneumococcal disease (IPD) in Indigenous children in remote Australia led to rapid introduction of 7-valent conjugate pneumococcal vaccine (7vPCV) at 2, 4 and 6 months in 2001, followed by 23-valent polysaccharide pneumococcal vaccine (23vPPV) in the second y...

journal_title：Vaccine

authors： Jayasinghe S,Chiu C,Menzies R,Lehmann D,Cook H,Giele C,Krause V,McIntyre P

更新日期：2015-11-27 00:00:00

abstract：BACKGROUND:Despite its high worldwide morbidity and mortality, there is yet no licensed vaccine for shigellosis. We reported the safety and immunogenicity of Shigella O-specific polysaccharide-protein conjugates in adults and young children and efficacy of Shigella sonnei conjugate in young adults. METHODS:A double-bl...

journal_title：Vaccine

authors： Passwell JH,Ashkenazi S,Banet-Levi Y,Ramon-Saraf R,Farzam N,Lerner-Geva L,Even-Nir H,Yerushalmi B,Chu C,Shiloach J,Robbins JB,Schneerson R,Israeli Shigella Study Group.

更新日期：2010-03-02 00:00:00

abstract：:Three recombinant strains of Mycobacterium bovis Bacille Calmette Guerin (rBCG) were prepared in which the immunogenic B subunit of human Escherichia coli heat labile enterotoxin (LT-Bh) was expressed either as a cytoplasm protein, a cell wall associated lipoprotein or a secreted protein. Intraperitoneal immunisation ...

journal_title：Vaccine

authors： Hayward CM,O'Gaora P,Young DB,Griffin GE,Thole J,Hirst TR,Castello-Branco LR,Lewis DJ

更新日期：1999-03-05 00:00:00

abstract：:The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV...

journal_title：Vaccine

authors： Akari H,Suzuki T,Ikeda K,Hoshino H,Tomono T,Murotsuka T,Terao K,Ito H,Yoshikawa Y

更新日期：1997-08-01 00:00:00

abstract：:Hepatitis B surface antigen (HBsAg) was detected in 3.3% of 7162 pregnant Tunisian women tested and HBeAg in 9.6% of the HBsAg-positive mothers. Family members of 46 of these HBsAg-positive mothers (33 husbands and 61 children aged 1-6 years) were investigated for the presence of HBV markers. HBsAg was detected in 21%...

journal_title：Vaccine

authors： Coursaget P,Gharbi Y,Khrouf N,Depril N,Boukhris N,Fritzell B,Kastally R

更新日期：1994-01-01 00:00:00

abstract：:As sensitivity to erythritol is the main feature of the Brucella abortus B19 vaccine strain, an attempt to define the genetic basis of this phenotypic trait was made in order to explore its usefulness as a means of molecular identification of strain B19. With this purpose, an erythritol-sensitive derivative of B. abor...

journal_title：Vaccine

authors： Sangari FJ,Agüero J

更新日期：1994-04-01 00:00:00