Secondary in vitro B lymphocyte (antibody) response to microbial antigens: use in appraisal of vaccine immunogenicity and cytokine immunoregulation.

abstract：:This study was designed to evaluate the immunogenicity of autoclaved and nonautoclaved preparations of a vaccine composed of whole antigens from killed promastigotes of Leishmania amazonensis. Leishmanin skin-test (LST)-negative volunteers were immunized with either autoclaved or nonautoclaved vaccine preparations (32...

journal_title：Vaccine

authors： De Luca PM,Mayrink W,Alves CR,Coutinho SG,Oliveira MP,Bertho AL,Toledo VP,Costa CA,Genaro O,Mendonça SC

更新日期：1999-03-05 00:00:00

abstract：:Immunization of hairless mice with a TK-, ACVr, non-pathogenic herpes simplex virus (HSV) type 1 mutant protected the mice against reinfection with lethal doses of the parental pathogenic HSV strain. The protection conferred by the mutant against the establishment of latency after reinfection with the parental strain ...

journal_title：Vaccine

authors： Klein RJ,Kaley LA,Friedman-Kien AE

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Simplified vaccine preparation steps would save time and reduce potential immunisation errors. The aim of the study was to assess vaccine preparation time with fully-liquid hexavalent vaccine (DTaP-IPV-HB-PRP-T, Sanofi Pasteur MSD) versus non-fully liquid hexavalent vaccine that needs reconstitution...

journal_title：Vaccine

authors： De Coster I,Fournie X,Faure C,Ziani E,Nicolas L,Soubeyrand B,Van Damme P

更新日期：2015-07-31 00:00:00

abstract：:Vaccines are needed to control zoonotic Schistosoma japonicum infection and several vaccine candidates have now been identified. Two of these (Sj28GST and Sj23) have shown particular promise in sheep when injected with Freund's adjuvants. The objective of the present work was to find a vaccine formulation which may ha...

journal_title：Vaccine

authors： Shi F,Zhang Y,Ye P,Lin J,Cai Y,Shen W,Bickle QD,Taylor MG

更新日期：2001-11-12 00:00:00

abstract：:The study evaluated the immunogenicity and efficacy of a trivalent subunit MF59-adjuvanted influenza vaccine (A/Wisconsin/67/05 (H3N2), A/Solomon Islands/3/06 (H1N1) and B/Malaysia/2506/04) in preventing serologically diagnosed infections in a group of 67 institutionalized elderly volunteers during 2007/2008 winter, c...

journal_title：Vaccine

authors： Camilloni B,Neri M,Lepri E,Basileo M,Sigismondi N,Puzelli S,Donatelli I,Iorio AM

更新日期：2010-11-03 00:00:00

abstract：:We show here that the immunogenicity of the Modified Vaccinia Ankara MVA vaccine strain can be improved by deletion of the A35 gene, without diminishing the ability of the virus to replicate. Deletion of the A35 gene resulted in increased virus-specific immunoglobulin production, class switching to IgG isotypes, and v...

journal_title：Vaccine

authors： Rehm KE,Roper RL

更新日期：2011-04-12 00:00:00

abstract：:Oral and inactivated poliomyelitis vaccines (OPV and IPV), were given to 160 children two months old, in a low income population at Rio de Janeiro. The vaccination was repeated 2 and 4 months later, always in association with diphtheria, tetanus and pertussis (DPT) vaccine. Blood specimens were collected before vaccin...

journal_title：Vaccine

authors： Schatzmayr HG,Maurice Y,Fujita M,de Fillipis AM

更新日期：1986-06-01 00:00:00

abstract：:Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenici...

journal_title：Vaccine

authors： Villa LL,Ault KA,Giuliano AR,Costa RL,Petta CA,Andrade RP,Brown DR,Ferenczy A,Harper DM,Koutsky LA,Kurman RJ,Lehtinen M,Malm C,Olsson SE,Ronnett BM,Skjeldestad FE,Steinwall M,Stoler MH,Wheeler CM,Taddeo FJ,Yu J,

更新日期：2006-07-07 00:00:00

abstract：:Rabies virus remains an important burden of disease claiming an estimated 60,000 lives each year, mainly children, and having a huge economical and societal cost. Post-exposure prophylaxis (PEP) is highly effective, however in patients that present with neurological symptoms the case-fatality ratio is extremely high (...

journal_title：Vaccine

authors： Jochmans D,Neyts J

更新日期：2019-08-02 00:00:00

abstract：:Human papillomavirus (HPV) infection is highly prevalent and can lead to cancer; the development of safe and efficacious vaccines for HPV is a major public health concern. The two licensed HPV vaccines contain recombinant virus-like particles of HPV 16 and 18; one of such vaccines also protects against HPV types 6 and...

journal_title：Vaccine

authors： Giacomet V,Penagini F,Trabattoni D,Viganò A,Rainone V,Bernazzani G,Bonardi CM,Clerici M,Bedogni G,Zuccotti GV

更新日期：2014-09-29 00:00:00

abstract：:The aims of this study were to evaluate the impact of hepatitis B vaccination on the changing pattern of HBV infection in a former hyperendemic area (Afragola, South Italy), and to assess the long-term persistence of anti-HBs in two cohorts of individuals vaccinated as infants 18 and 23 years ago. Our data shows a sig...

journal_title：Vaccine

authors： Da Villa G,Romanò L,Sepe A,Iorio R,Paribello N,Zappa A,Zanetti AR

更新日期：2007-04-20 00:00:00

abstract：BACKGROUND:The relative importance of different attitudes in predicting vaccination among healthcare personnel (HCP) is unclear. We hypothesized that HCP who feel at risk without vaccination or say they would regret not getting vaccinated would be more likely to get vaccinated than HCP who do not expect these emotional...

journal_title：Vaccine

authors： Thompson MG,Gaglani MJ,Naleway A,Ball S,Henkle EM,Sokolow LZ,Brennan B,Zhou H,Foster L,Black C,Kennedy ED,Bozeman S,Grohskopf LA,Shay DK

更新日期：2012-05-21 00:00:00

abstract：:Two hundred and fifty children born in 1967 and vaccinated with killed polio vaccine in Sweden were followed for 18 years and tested for neutralizing antibodies against polio. All of them had demonstrable antibodies at the age of 18. Sixty-four children were tested in samples collected throughout the years. After a mo...

journal_title：Vaccine

authors： Böttiger M

更新日期：1990-10-01 00:00:00

abstract：:The aim of this study was to determine the rubella seroprevalence in women of reproductive age. This cross-sectional study was conducted on women aged 15-49 years. Serologic studies were performed by using the ELISA method. The number of women enrolled in the study was 607, the mean age was 30.7+/-9.3 years and 13.2% ...

journal_title：Vaccine

authors： Sasmaz T,Kurt AO,Ozturk C,Bugdayci R,Oner S

更新日期：2007-01-15 00:00:00

abstract：:This study examines the potential clinical and economic benefits for adults arising from paediatric pneumococcal vaccination in the UK. A UK birth cohort model with a 10-year horizon and using a primary 4-dose paediatric 7-valent pneumococcal conjugate vaccine (PCV) schedule was populated with 1999 morbidity and morta...

journal_title：Vaccine

authors： McIntosh ED,Conway P,Willingham J,Hollingsworth R,Lloyd A

更新日期：2005-02-25 00:00:00

abstract：:Human papilloma virus (HPV) found in 99.7% of cervical cancers represents an attractive immunotherapeutic target for novel adjuvant dendritic cell (DC) immunotherapy. DC primed with HPV antigens have been shown to be capable of inducing CTL responses powerful enough to eradicate established murine tumours expressing H...

journal_title：Vaccine

authors： Adams M,Navabi H,Jasani B,Man S,Fiander A,Evans AS,Donninger C,Mason M

更新日期：2003-01-30 00:00:00

abstract：:GPI-0100 is a semi-synthetic saponin with modifications designed to augment stability and diminish toxicity. Two batches of GPI-0100 (the second with higher purity) were tested with doses ranging between 100 and 5000 microg in groups of five treated prostate cancer patients who had no evidence of disease except for ri...

journal_title：Vaccine

authors： Slovin SF,Ragupathi G,Fernandez C,Jefferson MP,Diani M,Wilton AS,Powell S,Spassova M,Reis C,Clausen H,Danishefsky S,Livingston P,Scher HI

更新日期：2005-05-02 00:00:00

abstract：:In a Phase 2a trial of the RTS,S/AS vaccine, we described significant association between protection against infection and vaccine-induced CD4 T cells. To determine whether processing of the circumsporozoite protein as a component of the RTS,S particulate antigen yields the same HLA-DR-restricted epitopes as those rec...

journal_title：Vaccine

authors： Schwenk R,Lumsden JM,Rein LE,Juompan L,Kester KE,Heppner DG,Krzych U

更新日期：2011-11-08 00:00:00

abstract：:Streptococcus pneumoniae is the leading cause of bacterial pneumonia, meningitis and sepsis in children worldwide. Despite available evidence on pneumococcal conjugate vaccine (PCV) impact on pneumonia hospitalizations in children, studies demonstrating PCV impact in morbidity and mortality in middle-income countries ...

journal_title：Vaccine

authors： Suarez V,Michel F,Toscano CM,Bierrenbach AL,Gonzales M,Alencar AP,Ruiz Matus C,Andrus JK,de Oliveira LH

更新日期：2016-09-07 00:00:00

abstract：:Patients with malignancies are considered to be at increased risk of acquiring influenza. Because of higher complication and case fatality rates, preventive measures such as vaccination are of great interest. The objective of this study was to assess the acceptability, tolerability and immunogenicity of an adjuvant-fr...

journal_title：Vaccine

authors： Lagler H,Tobudic S,Ramharter M,Elandt K,Sperr WR,Redlberger-Fritz M,Popow-Kraupp T,Jäger U,Zielinski CC,Burgmann H

更新日期：2012-11-06 00:00:00

abstract：:The canarypox vaccine vector (ALVAC) technology has been used to develop and license several vaccines for companion animals and horses in the European Union and USA. ALVAC is a ubiquitous vector with high biosafety since it is non-replicative in mammalians, is genetically and physically stable, and able to induce both...

journal_title：Vaccine

authors： Poulet H,Minke J,Pardo MC,Juillard V,Nordgren B,Audonnet JC

更新日期：2007-07-26 00:00:00

abstract：:Influenza becomes epidemic worldwide every year, and many individuals receive vaccination annually. Quality control relating to safety and potency of influenza vaccines is important to maintain public confidence. The safety of influenza vaccines has been assessed by clinical trials, and animal safety tests are perform...

journal_title：Vaccine

authors： Momose H,Sasaki E,Kuramitsu M,Hamaguchi I,Mizukami T

更新日期：2018-10-15 00:00:00

abstract：OBJECTIVES:We aimed to estimate vaccine effectiveness against severe measles based on the number of vaccine doses administered and the time since last vaccination. PATIENTS AND METHODS:We included measles cases aged at least 2 years and born since 1980 who were notified in France between 2006 and mid-2019. We consider...

journal_title：Vaccine

authors： Bonneton M,Antona D,Danis K,Aït-Belghiti F,Levy-Bruhl D

更新日期：2020-06-15 00:00:00

abstract：:A recombinant fowlpox vaccine with an H5 hemagglutinin gene insert protected chickens against clinical signs and death following challenge by nine different highly pathogenic H5 avian influenza viruses. The challenge viruses had 87.3 to 100% deduced hemagglutinin amino acid sequence similarity with the recombinant vac...

journal_title：Vaccine

authors： Swayne DE,Garcia M,Beck JR,Kinney N,Suarez DL

更新日期：2000-01-06 00:00:00

abstract：:Tuberculosis (TB) is the biggest cause of human mortality from an infectious disease. The only vaccine currently available, bacille Calmette-Guérin (BCG), demonstrates some protection against disseminated disease in childhood but very variable efficacy against pulmonary disease in adults. A greater understanding of pr...

journal_title：Vaccine

authors： Bull NC,Kaveh DA,Garcia-Pelayo MC,Stylianou E,McShane H,Hogarth PJ

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:Several chronic disease states have been identified as pneumococcal vaccination indications due to their ability to increase pneumococcal disease development and subsequent mortality. However, the risk of mortality according to the number of these disease states present is unknown. We sought to determine the...

journal_title：Vaccine

authors： Morton JB,Morrill HJ,LaPlante KL,Caffrey AR

更新日期：2017-03-23 00:00:00

abstract：:Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD50. The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challen...

journal_title：Vaccine

authors： Eldar A,Shapiro O,Bejerano Y,Bercovier H

更新日期：1995-06-01 00:00:00

abstract：:Meat contamination by Salmonella spp. is emerging as a major cause of human enteric infections in industrialized countries. The attempts to reduce human cases of salmonellosis encompass pre- and post-harvest interventions. In this context, vaccination of pigs may represent an effective instrument in eliminating/reduci...

journal_title：Vaccine

authors： Pesciaroli M,Gradassi M,Martinelli N,Ruggeri J,Pistoia C,Raffatellu M,Magistrali CF,Battistoni A,Pasquali P,Alborali GL

更新日期：2013-06-12 00:00:00

abstract：:Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vaccine based on the atte...

journal_title：Vaccine

authors： Cook E,Russell G,Grant D,Mutisya C,Omoto L,Dobson E,Lankester F,Nene V

更新日期：2019-09-20 00:00:00

abstract：:Seasonal influenza epidemics represent a substantial public health burden, causing significant morbidity and mortality. Influenza in humans can be caused by influenza type A and type B viruses, and although influenza A is responsible for the majority of seasonal influenza infections, influenza B disease is common in c...

journal_title：Vaccine

authors： Belshe RB

更新日期：2010-09-07 00:00:00