Abstract：
:The smallpox vaccine Vaccinia was successfully used to eradicate smallpox, but although very effective, it was a very reactogenic vaccine and responsible for the deaths of one or two people per million vaccinated. Modified Vaccinia virus Ankara (MVA) is a replication-deficient and attenuated derivative, also used in the smallpox eradication campaign and now being developed as a recombinant viral vector to produce vaccines against infectious diseases and cancer. Many clinical trials of these new vaccines have been conducted, and the findings of these trials are reviewed here. The safety of MVA is now well documented, immunogenicity is influenced by the dose and vaccination regimen, and information on the efficacy of MVA-vectored vaccines is now beginning to accumulate.
journal_name
Vaccinejournal_title
Vaccineauthors
Gilbert SCdoi
10.1016/j.vaccine.2013.03.020subject
Has Abstractpub_date
2013-09-06 00:00:00pages
4241-6issue
39eissn
0264-410Xissn
1873-2518pii
S0264-410X(13)00304-6journal_volume
31pub_type
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