Abstract:
INTRODUCTION:Rotavirus infection mainly affects children under 5 years of age and causes 453,000 deaths annually throughout the world. Several countries in Latin America have introduced the rotavirus vaccine and the majority have epidemiological data to measure impact following vaccine introduction. OBJECTIVE:To assess the impact of rotavirus immunization on the number of all-cause diarrhea-related deaths and hospitalizations in children under 1 and 5 years of age in Bolivia, El Salvador, Honduras and Venezuela. METHODS:Interrupted time-series analyzed with the integral method and the projection method to evaluate the pre and post-vaccine introduction trend in diarrheal disease compared to Argentina as the control country. The analysis period was from 2002 to 2010, including 2 to 4 post-vaccine years depending on the country. Information sources included records from PAHO, the Ministry of Health, public hospitals, social security, the private health system, the Expanded Programme on Immunization and UNPop 2008. RESULTS:Over the period studied, reductions were observed in trends of diarrhea-related deaths and hospitalizations in children under five. In diarrhea-related deaths, under the integral method, the range of reduction was between 15.7% (13.5-17.9) and 56.8% (56.0-57.5) while with the projection method was between 19.9% (4.9-34.8) and 63.7%(56.1-71.4). In diarrhea-related hospitalizations, under the integral method was 5.6% (4.1-6.7) and 17.9% (16.7-19.1)) while with the projection method was between 5.1%(1.7-8.7) and 11.1% (5.8-16.3) CONCLUSIONS: A decrease was observed in the number of diarrhea related deaths and hospitalizations in all countries under study following introduction of the rotavirus vaccine as opposed to the control country. The impact on reduction of deaths was greater than hospitalization.
journal_name
Vaccinejournal_title
Vaccineauthors
De Oliveira LH,Giglio N,Ciapponi A,García Martí S,Kuperman M,Sanwogou NJ,Ruiz-Matus C,Marinho de Sousa MFdoi
10.1016/j.vaccine.2013.05.065subject
Has Abstractpub_date
2013-07-02 00:00:00pages
C99-108eissn
0264-410Xissn
1873-2518pii
S0264-410X(13)00667-1journal_volume
31 Suppl 3pub_type
杂志文章,评审相关文献
VACCINE文献大全abstract::The murine cytomegalovirus (MCMV) glycoprotein B (gB) gene was expressed in an adenovirus replication-deficient vector. This virus, designated Ad-gB, was used to immunize BALB/c and B6 mice by the intranasal (i.n.) route to induce an immune response. Following primary immunization, antibody was detected in serum of 10...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(03)00037-9
更新日期:2003-06-02 00:00:00
abstract::In a 12-month cohort follow-up study of 2435 children vaccinated in 2007 by Statens Serum Institute BCG strain (BCG SSI, 17.8% had an adverse event (AE): erythema 12.4%, induration 12.2%, abscesses 2.5%, ulceration 0.9%, lymphadenitis 0.1%. The factors associated with a lower risk of AE were: age at vaccination <1 yea...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2009.09.073
更新日期:2009-11-23 00:00:00
abstract::We previously demonstrated that intradermal and intramuscular vaccination with Leishmania amazonensis promastigote antigens (LaAg) increases the susceptibility of BALB/c mice to cutaneous leishmaniasis. In this study, we investigated the role played by serine and cysteine proteases as disease-promoting components of L...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.04.109
更新日期:2010-07-26 00:00:00
abstract::We successfully re-vaccinated hepatitis B virus (HBV) vaccine non-responders using a double dose of the combined hepatitis A virus (HAV) and HBV vaccine. The hope was to improve priming of hepatitis B surface antigen (HBsAg)-specific cell mediated immune response (CMI) by an increased antigen dose and a theoretical ad...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.08.054
更新日期:2008-11-05 00:00:00
abstract::Hookworm infection is a significant problem worldwide. As development of hookworm vaccine proceeds, it is essential for vaccine developers and manufacturers, policy makers, and other public health officials to understand the potential costs and benefits of such a vaccine. We developed a decision analytic model to eval...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.12.004
更新日期:2011-02-01 00:00:00
abstract::The present study assessed the efficacy of Clostridium perfringens (C. perfringens) toxoid and/or allicin - as feed additive - in rabbits for preventing or minimizing the severity of infection with locally isolated strain of C. perfringens type A. Serum biochemical, immunological and pathological investigations were a...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.02.073
更新日期:2016-04-12 00:00:00
abstract::Sequential or co-administration of vaccines has potential to alter the immune response to any of the antigens. Existing literature suggests that prior immunisation of tetanus/diphtheria-containing vaccines can either enhance or suppress immune response to conjugate pneumococcal or meningococcal vaccines. We examined t...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.vaccine.2016.10.020
更新日期:2016-11-21 00:00:00
abstract::In order to meet the global demand for rapid production of pandemic influenza vaccines, we have developed a recombinant fusion vaccine platform in which the globular head of hemagglutinin (HA) antigen is genetically fused to bacterial flagellin (a TLR5 ligand). These flagellin-HA fusion vaccine candidates elicit highl...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.09.013
更新日期:2012-11-06 00:00:00
abstract::In 1994, 630 Gambian infants were immunized with three doses of the synthetic polypeptide malaria vaccine SPf66 or with a control vaccine. No significant protection against first or total attacks of malaria was observed among the children who received SPf66. However, the period of follow-up was short. Thus, 532 childr...
journal_title:Vaccine
pub_type: 临床试验,杂志文章
doi:10.1016/s0264-410x(97)00159-x
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:As congenital cytomegalovirus (CMV) infection is one of the major causes of birth defects and developmental abnormalities, it is essential to develop vaccines and therapeutic antibodies against CMV. Clinical trials demonstrated that the subunit vaccine based on glycoprotein B, which had been believed to be...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.08.054
更新日期:2018-09-25 00:00:00
abstract::The smallpox vaccine Vaccinia was successfully used to eradicate smallpox, but although very effective, it was a very reactogenic vaccine and responsible for the deaths of one or two people per million vaccinated. Modified Vaccinia virus Ankara (MVA) is a replication-deficient and attenuated derivative, also used in t...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2013.03.020
更新日期:2013-09-06 00:00:00
abstract::TA-CIN is a vaccine that comprises the human papillomavirus (HPV) type 16 L2, E6 and E7 as a single fusion protein. In a mouse model, TA-CIN effectively prevented outgrowth of HPV16-positive tumour cells. To assess the safety and immunogenicity of TA-CIN, a dose escalating (26, 128, 533 micro g), double blind and plac...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0264-410x(02)00350-x
更新日期:2002-10-04 00:00:00
abstract::Bacterially-displayed peptide libraries have been widely used as an alternative to phage-displayed peptide libraries in screening epitopes or mimotopes of antibodies. Using a protective monoclonal antibody (mAb) 3B9 against hepatitis B virus (HBV) preS protein as target, mimotopes were successfully screened from a Fli...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(03)00436-5
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:Implementation of the 7-valent pneumococcal conjugate vaccine (PCV7) in infant vaccination programs has substantially reduced the burden of PCV7 serotypes also in adult community-acquired pneumonia (CAP). Currently, it is unclear, if this extensive herd protection effect can be extrapolated to the addition...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.11.026
更新日期:2020-01-29 00:00:00
abstract::The knowledge that the immune system is composed of a regulatory/suppressor arm added a new point of view to better understand the nature of several pathologies including cancer, transplants, infections and autoimmune diseases. The striking discoveries concerning molecules and cells involved in this kind of regulation...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2019.05.015
更新日期:2019-06-19 00:00:00
abstract::Randomized controlled clinical trials represent the best way to establish the therapeutic or preventive value of medicines. This decade has seen a strong shift in the location of clinical trials from industrialized countries to developing countries, including many in Africa. However, without independent strong regulat...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.08.113
更新日期:2009-12-09 00:00:00
abstract:BACKGROUND:Protein-polysaccharide conjugate vaccines such as Haemophilus influenzae type b (Hib), meningococcal, and pneumococcal vaccine, induce immunological memory and longer lasting protection than plain polysaccharide vaccines. The most common proteins used as carriers are tetanus toxoid (TT) and cross reacting ma...
journal_title:Vaccine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.vaccine.2016.06.038
更新日期:2016-07-25 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS:We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospita...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.06.048
更新日期:2014-07-31 00:00:00
abstract::The aim of this study was to characterize the adverse events of attenuated measles vaccine in mainland China. We carried out prospective follow-up of adverse events after mass measles immunization practices, categorizing them into two groups: allergic reactions and serious adverse events. The incidence of anaphylaxis ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.10.106
更新日期:2011-04-18 00:00:00
abstract::Two compound Chinese herbal medicinal ingredients (cCHMIs) were prepared, respectively, with epimedium polysaccharide plus propolis flavone (cCHMIs 1) and astragalus polysaccharide plus ginsenoside (cCHMIs 2). In animal immune experiment, Newcastle disease vaccine was mixed, respectively, with two cCHMIs and IL-2 to v...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.07.005
更新日期:2006-11-30 00:00:00
abstract::In 2017, the World Health Organization (WHO) published a document aimed at facilitating influenza vaccine introduction and use in low- and middle-income countries. The document "The Immunological Basis for Immunization Series: Influenza Vaccines" is freely available on the WHO website. The main purpose of this documen...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.09.010
更新日期:2018-09-05 00:00:00
abstract::We sought to determine the vaccine effectiveness (VE) of Lanzhou lamb rotavirus (LLR) vaccine against rotavirus gastroenteritis in children <5 requiring hospitalization. Children hospitalized 2002-2004 with rotavirus gastroenteritis were matched by gender, age and community to 838 controls. VE was calculated for one o...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.10.036
更新日期:2007-12-17 00:00:00
abstract:BACKGROUND:Despite its high worldwide morbidity and mortality, there is yet no licensed vaccine for shigellosis. We reported the safety and immunogenicity of Shigella O-specific polysaccharide-protein conjugates in adults and young children and efficacy of Shigella sonnei conjugate in young adults. METHODS:A double-bl...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2009.12.050
更新日期:2010-03-02 00:00:00
abstract::Pre-fusion stabilizing mutations (DS-Cav1) in soluble fusion (F) proteins of human respiratory syncytial virus (RSV) were previously reported. Here we investigated the antigenic and immunogenic properties of pre-fusion like RSV F proteins on enveloped virus-like particles (VLP). Additional mutations were introduced to...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.09.041
更新日期:2019-10-16 00:00:00
abstract::Over a period of 1 year a seroepidemiological study was conducted at the outpatient clinic of a trauma department. Immunity to diphtheria was determined in serum samples from 558 injured patients (205 women and 353 men, age from 18 to 70). Diphtheria-antitoxin concentrations were measured with an enzyme immunoassay an...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(00)00341-8
更新日期:2000-12-08 00:00:00
abstract::Children in public care have poor health outcomes despite statutory health assessments. Incomplete immunisation of children entering the care system has been reported. Does this health disadvantage persist for those established in the care system? The immunisation status of 119 children in public care for at least 6 m...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.12.001
更新日期:2005-04-15 00:00:00
abstract:BACKGROUND:BCR/ABL and Wilms' tumor 1 (WT1) are an ideal tumor associated antigens which can be used to develop a potential chronic myeloid leukemia (CML) dentritic cell (DC) vaccine. Here, we constructed a novel polyepitope vaccine which used recombinant lentiviral vector carrying BCR/ABL and WT1 genes, and determined...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.04.041
更新日期:2014-06-12 00:00:00
abstract::A growing number of people use the Internet to obtain health information, including information about vaccines. Websites that allow and promote interaction among users are an increasingly popular source of health information. Users of such so-called Web 2.0 applications (e.g. social media), while still in the minority...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.02.025
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Increased travel to exotic destinations around the world is escalating the risk of exposure to animal-associated injuries with a risk of acquiring rabies. METHODS:We have examined data reported to GeoSentinel Surveillance Network to highlight characteristics of animal-associated injuries in travellers. RES...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.12.034
更新日期:2007-03-30 00:00:00
abstract::Tick-borne encephalitis (TBE) is a potentially serious disease, especially in adults. There is no treatment available for TBE; supportive therapy may help to ease symptoms of the disease. Vaccination is the most effective method of preventing TBE disease and is recommended for those who live, work, or travel in TBE-en...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.11.082
更新日期:2009-02-05 00:00:00