The potential economic value of a hookworm vaccine.

abstract：:A hybrid protein [Met-Ala-(His)(6) OprF(190-342)-OprI(21-83)] consisting of the mature outer membrane protein I (OprI) and amino acids 190-342 of OprF of Pseudomonas aeruginosa was expressed in Escherichia coli and purified by Ni(2+) chelate-affinity chromatography. After several studies in healthy volunteers, as well...

journal_title：Vaccine

authors： Larbig M,Mansouri E,Freihorst J,Tümmler B,Köhler G,Domdey H,Knapp B,Hungerer KD,Hundt E,Gabelsberger J,von Specht BU

更新日期：2001-03-21 00:00:00

abstract：:The emergence of lineage 2 strains of WNV in Europe as a cause of clinical disease and mortality in horses raised the question whether the existing WNV vaccines, all based on lineage 1 strains, protect against circulating lineage 2 strains of WNV. In the present paper we have determined the level of cross protection p...

journal_title：Vaccine

authors： Minke JM,Siger L,Cupillard L,Powers B,Bakonyi T,Boyum S,Nowotny N,Bowen R

更新日期：2011-06-20 00:00:00

abstract：:Non-pathogenic lactic acid bacteria (LAB) are attractive as live carriers to deliver protective antigens to the mucosal immune system. Both persisting and non-persisting strains of lactic acid bacteria have been evaluated and seem to work equally well by the systemic and nasal routes of administration. However, it is ...

journal_title：Vaccine

authors： Grangette C,Müller-Alouf H,Geoffroy M,Goudercourt D,Turneer M,Mercenier A

更新日期：2002-09-10 00:00:00

abstract：:Chlamydia trachomatis causes respiratory and sexually transmitted infections. Here, we tested a vaccine formulated with the recombinant major outer membrane protein from C. trachomatis mouse pneumonitis (CT-MoPn) for its ability to protect mice against an intranasal (i.n.) challenge. The adjuvants CpG and Montanide we...

journal_title：Vaccine

authors： Ralli-Jain P,Tifrea D,Cheng C,Pal S,de la Maza LM

更新日期：2010-11-10 00:00:00

abstract：:Three vaccines, BCG alone, BCG + 10(7) killed Mycobacterium vaccae and 10(8) killed M. vaccae alone, were studied in children living in close contact with leprosy. In the year before vaccination, 14/446 (3.1%) children had developed leprosy. Among those who were not vaccinated, 9/74 (12.2%) developed the disease in th...

journal_title：Vaccine

authors： Truoc LV,Ly HM,Thuy NK,Trach DD,Stanford CA,Stanford JL

更新日期：2001-05-14 00:00:00

abstract：:Every year, meningococcal meningitis causes thousands of deaths within the meningitis belt in sub-Saharan African countries. Large epidemic waves occur with a periodicity of 5-12 years. The waves do correspond to molecular changes in the expression of capsular or subcapsular antigens, which allow the bug to spread in ...

journal_title：Vaccine

authors： Teyssou R,Muros-Le Rouzic E

更新日期：2007-09-03 00:00:00

abstract：:Immunization of pregnant women against influenza is a promising strategy to protect the mother, fetus, and young infant from influenza-related diseases. The burden of influenza during pregnancy, the vaccine immunogenicity during this period, and the robust influenza vaccine safety database underpin recommendations tha...

journal_title：Vaccine

authors： Ortiz JR,Neuzil KM,Ahonkhai VI,Gellin BG,Salisbury DM,Read JS,Adegbola RA,Abramson JS

更新日期：2012-11-26 00:00:00

abstract：:This article presents the World Health Organization's (WHO) recommendations on the use of polio vaccine excerpted from the WHO position paper on polio vaccines - March 2016, published in the Weekly Epidemiological Record [1]. This position paper on polio vaccines replaces the 2014 WHO position paper [2]. The position ...

journal_title：Vaccine

authors： World Health Organization

更新日期：2017-03-01 00:00:00

abstract：:Dengue is one of the most important arboviral diseases in humans, and although efforts over the last decades have dealt with the development of a vaccine, this vaccine is not available yet. In order to evaluate the potential of a DNA vaccine based on the non-structural 1 (NS1) protein against dengue virus (DENV), we c...

journal_title：Vaccine

authors： Costa SM,Paes MV,Barreto DF,Pinhão AT,Barth OM,Queiroz JL,Armôa GR,Freire MS,Alves AM

更新日期：2006-01-12 00:00:00

abstract：:We report influenza vaccination coverage in target groups for the 2010-2011 influenza season, one year after the A(H1N1) pandemic. Data were collected through a one-stage cross-sectional national random telephone survey conducted in January 2011 among a sample of the population of mainland France connected to a land t...

journal_title：Vaccine

authors： Guthmann JP,Fonteneau L,Bonmarin I,Lévy-Bruhl D

更新日期：2012-02-01 00:00:00

abstract：:A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eve...

journal_title：Vaccine

authors： Palacpac NM,Arisue N,Tougan T,Ishii KJ,Horii T

更新日期：2011-08-11 00:00:00

abstract：:The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronega...

journal_title：Vaccine

authors： Givens MD,Riddell KP,Walz PH,Rhoades J,Harland R,Zhang Y,Galik PK,Brodersen BW,Cochran AM,Brock KV,Carson RL,Stringfellow DA

更新日期：2007-01-15 00:00:00

abstract：:Since vaccination against human papillomavirus (HPV) became available, awareness of HPV has dramatically increased. Implementation of a vaccine program varies internationally yet no studies have explored the influence this has on the public's knowledge of HPV. The present study aimed to explore differences in awarenes...

journal_title：Vaccine

authors： Marlow LA,Zimet GD,McCaffery KJ,Ostini R,Waller J

更新日期：2013-01-21 00:00:00

abstract：:The bioavailability of oseltamivir phosphate and oseltamivir carboxylate were assessed in healthy volunteers when delivered as a solution of the active pharmaceutical ingredient (API) compared with the commercial capsule formulation. The 90% confidence intervals (CIs) for the ratios of the two treatments (capsule vers...

journal_title：Vaccine

authors： Brewster M,Smith JR,Dutkowski R,Robson R

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:In 2018/19, English NHS trusts (NHSTs) implemented an 'opt-out' policy for seasonal flu vaccination in frontline healthcare workers (HCWs). HCWs declining the vaccination were asked to sign an opt-out form and provide a reason for their decision. In addition, HCWs working in higher risk hospital environments...

journal_title：Vaccine

authors： Bell S,Chantler T,Paterson P,Mounier-Jack S

更新日期：2020-05-27 00:00:00

abstract：:Therapeutic immunization of HIV-1-infected individuals with or without anti-retroviral therapy is a new promising disease prevention. To induce a new cytotoxic T(CD8) lymphocyte (CTL) immunity during chronic HIV-1 infection 15 infrequently targeted but conserved HLA-supertype binding CTL epitopes from Gag, Pol, Nef, E...

journal_title：Vaccine

authors： Fomsgaard A,Karlsson I,Gram G,Schou C,Tang S,Bang P,Kromann I,Andersen P,Andreasen LV

更新日期：2011-09-16 00:00:00

abstract：BACKGROUND:Hepatitis B (HepB) vaccination is the most effective measure to prevent HBV infection. Routine HepB vaccination was recommended for infants in 1991 and catch-up vaccination has been recommended for adolescents since in 1995. The purpose of this study is to assess HepB vaccination among adolescents 13-17 year...

journal_title：Vaccine

authors： Lu PJ,Yankey D,Jeyarajah J,O'Halloran A,Elam-Evans L,Greby SM,Singleton JA,Murphy TV

更新日期：2015-04-08 00:00:00

abstract：BACKGROUND:In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys. METHODS:The cultures of SARS coronavirus (SARS-CoV) BJ-01 strain infected Vero cells we...

journal_title：Vaccine

authors： Qin E,Shi H,Tang L,Wang C,Chang G,Ding Z,Zhao K,Wang J,Chen Z,Yu M,Si B,Liu J,Wu D,Cheng X,Yang B,Peng W,Meng Q,Liu B,Han W,Yin X,Duan H,Zhan D,Tian L,Li S,Wu J,Tan G,Li Y,Li Y,Liu Y,Liu H,Lv F

更新日期：2006-02-13 00:00:00

abstract：:EG95 is a recombinant vaccine protein that elicits protection against hydatid disease in sheep. Previous studies have shown that the host-protective epitopes on EG95 depend on correct conformation and cannot be represented by simple "linear" peptides. By screening random peptide phage display libraries with polyclonal...

journal_title：Vaccine

authors： Read AJ,Casey JL,Coley AM,Foley M,Gauci CG,Jackson DC,Lightowlers MW

更新日期：2009-02-11 00:00:00

abstract：:To test several vaccines for Chlamydia trachomatis we vaccinated BALB/c and C3H/HeN female mice with a purified preparation of the native mouse pneumonitis (MoPn) major outer membrane protein (MOMP). The MOMP was formulated with anyone of three different adjuvants MF59, LT-K63 or LT-R72. As a negative control the anim...

journal_title：Vaccine

authors： Pal S,Peterson EM,Rappuoli R,Ratti G,de la Maza LM

更新日期：2006-02-06 00:00:00

abstract：:Vaccination of health-care workers (HCWs) against seasonal influenza has been consistently recommended worldwide in order to prevent nosocomial transmission and ensure delivery of health-care services during outbreaks. We describe the effects of a nationwide campaign to promote influenza vaccination among HCWs working...

journal_title：Vaccine

authors： Dedoukou X,Nikolopoulos G,Maragos A,Giannoulidou S,Maltezou HC

更新日期：2010-08-23 00:00:00

abstract：:CD1d-binding glycolipids exert potent adjuvant effects on T-dependent Ab responses. The mechanisms include cognate interaction between CD1d-expressing B cells and TCR-expressing Type I CD1d-restricted natural killer T cells (NKTs). However, the critical NKT-derived factors that stimulate B cells are poorly understood....

journal_title：Vaccine

authors： Shah HB,Joshi SK,Lang ML

更新日期：2011-11-15 00:00:00

abstract：:On February 17-18, 2010, the World Health Organization (WHO) convened the 6th meeting on the "Evaluation of pandemic influenza vaccines in clinical trials" to review the progress made on new A (H1N1) 2009 vaccines and prototype H5N1 vaccines and their evaluation in clinical trials. A number of vaccine types were revie...

journal_title：Vaccine

authors： Girard MP,Katz J,Pervikov Y,Palkonyay L,Kieny MP

更新日期：2010-10-04 00:00:00

abstract：:We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 mon...

journal_title：Vaccine

authors： Cheng AC,Kotsimbos T,Kelly HA,Irving LB,Bowler SD,Brown SG,Holmes M,Jenkins CR,Thompson P,Simpson G,Wood-Baker R,Senanayake SN,Brady SJ,Paterson DL,Wark PA,Upham JW,Korman TM,Dwyer DE,Waterer GW,Kelly PM

更新日期：2011-10-06 00:00:00

abstract：:SPf66 is the first chemically synthesised vaccine to elicit a partial protective immune response against malaria. The aluminium hydroxide (alum)-adsorbed SPf66 vaccine is weakly immunogenic and of poor to moderate efficacy in humans. To investigate the possibility of improving SPf66 vaccine immunogenicity, a delivery ...

journal_title：Vaccine

authors： Rosas JE,Hernández RM,Gascón AR,Igartua M,Guzman F,Patarroyo ME,Pedraz JL

更新日期：2001-08-14 00:00:00

abstract：:Mucosal adjuvants are important to overcome the state of immune tolerance normally associated with mucosal delivery and to enhance adaptive immunity to often-weakly immunogenic subunit vaccine antigens. Unfortunately, adverse side effects of many experimental adjuvants limit the number of adjuvants approved for vaccin...

journal_title：Vaccine

authors： Hickey DK,Aldwell FE,Beagley KW

更新日期：2009-10-19 00:00:00

abstract：:We have evaluated in C57/Bl6 and HLA-A2.1 transgenic mice the immunogenicity of three MVA vectors expressing either native HCV E1E2 polyprotein, truncated and secreted E1 (E'1(311)) and E2 (E'2(661)) proteins, or a chimeric E1E2 heterodimer presented at the plasma membrane. Immunization induced mainly a Th1 response i...

journal_title：Vaccine

authors： Abraham JD,Himoudi N,Kien F,Berland JL,Codran A,Bartosch B,Baumert T,Paranhos-Baccala G,Schuster C,Inchauspé G,Kieny MP

更新日期：2004-09-28 00:00:00

abstract：:Human intestinal infections with the nematode Strongyloides stercoralis remain a significant problem worldwide and a vaccine would be a useful addition to the tools available to prevent and control this infection. The goal of this study was to test single antigens for their efficacy in a vaccine against S. stercoralis...

journal_title：Vaccine

authors： Abraham D,Hess JA,Mejia R,Nolan TJ,Lok JB,Lustigman S,Nutman TB

更新日期：2011-10-19 00:00:00

abstract：:Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentou...

journal_title：Vaccine

authors： Frenkel D,Dewachter I,Van Leuven F,Solomon B

更新日期：2003-03-07 00:00:00

abstract：:The paramyxoviruses respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) are the two most common agents of severe lower respiratory tract disease in infants and children throughout the world. RSV causes yearly epidemics of bronchiolitis and pneumonia in infants and young children, while PIV3 is a co...

journal_title：Vaccine

authors： Crowe JE Jr

更新日期：1995-03-01 00:00:00