Abstract：
:Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentous phage. The EFRH phage evoked effective auto-immune antibodies in amyloid precursor protein [V717I] (APP[V717I]) transgenic mice that recapitulate the amyloid plaques and vascular pathology of Alzheimer's disease (AD). The immunization provoked a considerable reduction in the number of Abeta amyloid plaques in the brain of the transgenic mice and may serve as the basis for anti-Abeta vaccine.
journal_name
Vaccinejournal_title
Vaccineauthors
Frenkel D,Dewachter I,Van Leuven F,Solomon Bdoi
10.1016/s0264-410x(02)00609-6subject
Has Abstractpub_date
2003-03-07 00:00:00pages
1060-5issue
11-12eissn
0264-410Xissn
1873-2518pii
S0264410X02006096journal_volume
21pub_type
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