Abstract：
:A 33-mer peptide of the alpha-gliadin component of gluten was recently identified as primary initiator of the inflammatory response to gluten in coeliac disease (CD) patients. This proline-glutamine-rich peptide (PG-peptide) is highly homologous to internal sequence of pertactin, an immunogenic protein of Bordetella pertussis. Using enzyme immunoassays, we measured serum antibodies to pertactin and to PG-peptide in 167 Finnish subjects including pertussis vaccine recipients and pertussis patients, CD and non-CD patients and healthy individuals. We found no cross-reactivity between human antibodies to the two different components, suggesting that neither pertussis immunization nor disease contributes to the pathogenesis of CD.
journal_name
Vaccinejournal_title
Vaccineauthors
He Q,Viljanen MK,Hinkkanen AE,Arvilommi H,Mertsola J,Viander Mdoi
10.1016/j.vaccine.2005.01.078subject
Has Abstractpub_date
2005-05-09 00:00:00pages
3336-40issue
25eissn
0264-410Xissn
1873-2518pii
S0264-410X(05)00119-2journal_volume
23pub_type
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