Abstract：
:We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.
journal_name
Vaccinejournal_title
Vaccineauthors
Surendran N,Nicolosi T,Pichichero Mdoi
10.1016/j.vaccine.2016.09.050subject
Has Abstractpub_date
2016-11-11 00:00:00pages
5700-5703issue
47eissn
0264-410Xissn
1873-2518pii
S0264-410X(16)30875-1journal_volume
34pub_type
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