Abstract：
:The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P > 0.1) while antibody titres to tetanus toxoid were higher in the later group (P < 0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.
journal_name
Vaccinejournal_title
Vaccineauthors
Begg NT,Miller E,Fairley CK,Chapel HM,Griffiths H,Waight PA,Ashworth LAdoi
10.1016/0264-410x(95)00091-esubject
Has Abstractpub_date
1995-11-01 00:00:00pages
1547-50issue
16eissn
0264-410Xissn
1873-2518pii
0264410X9500091Ejournal_volume
13pub_type
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