Abstract:
:Live Shigella flexneri 2a and Shigella sonnei Phase I vaccine candidate strains with two virulence-reducing markers were constructed through stepwise incorporation of weakly attenuating purine auxotrophy with subsequent rifampicin-resistance (RNA polymerase) mutation to yield optimal attenuation. These vaccine candidate strains showed an unaltered plasmid profile; did not cause keratoconjunctivitis in the Sereny test, while being excreted for a short but still marked period and providing partial protection from wild-strain infection; exhibited for guinea-pig conjunctival epithelia, HeLa cells and rat enterocytes a maintained invasiveness with reduced intracellular multiplication with little, if any, reversible cell damage; and produced, just as their ultrasonic lysates, no exudative reaction in the rabbit gut loop test.
journal_name
Vaccinejournal_title
Vaccineauthors
Linde K,Dentchev V,Bondarenko V,Marinova S,Randhagen B,Bratoyeva M,Tsvetanov Y,Romanova Ydoi
10.1016/0264-410x(90)90173-jsubject
Has Abstractpub_date
1990-02-01 00:00:00pages
25-9issue
1eissn
0264-410Xissn
1873-2518pii
0264-410X(90)90173-Jjournal_volume
8pub_type
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