The burden of hospitalisations for community-acquired pneumonia (CAP) and pneumococcal pneumonia in adults in Spain (2003-2007).


:All hospital discharges and deaths related to CAP and pneumococcal-pneumonia from adults over 50 from 2003 to 2007 in Spain were obtained. Among the 447,670 Pneumonia-all causes discharges 17% were pneumococcal pneumonia. The annual hospitalisation rate was 6.27 and 1.09 cases per 1000, respectively. 75,932 deaths for Pneumonia-all causes and 9062 for pneumococcal-pneumonia were reported. CAP and pneumococcal pneumonia are major causes of morbidity and mortality in Spain, especially in the elderly. Despite current preventive measures, no significant changes in hospitalisation, mortality and case-fatality rates were found over the study period. Future preventive measures, like vaccination, could overcome these limitations.






Gil-Prieto R,García-García L,Alvaro-Meca A,Méndez C,García A,de Miguel AG




Has Abstract


2011-01-10 00:00:00
















  • Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines.

    abstract::The formulation of plasmid DNA (pDNA) in cationic liposomes is a promising strategy to improve the potency of DNA vaccines. In this respect, physicochemical parameters such as liposome size may be important for their efficacy. The aim of the current study was to investigate the effect of vesicle size on the in vivo pe...


    pub_type: 杂志文章


    authors: Carstens MG,Camps MG,Henriksen-Lacey M,Franken K,Ottenhoff TH,Perrie Y,Bouwstra JA,Ossendorp F,Jiskoot W

    更新日期:2011-06-24 00:00:00

  • Choice of measures of vaccination and estimates of risk of pediatric pertussis.

    abstract:BACKGROUND:Vaccination uptake at the individual level can be assessed in a variety of ways, including traditional measures of being up-to-date (UTD), measures of UTD that consider dose timing, like age-appropriate vaccination, and risk reduction from individual doses. This analysis compared methods of operationalizing ...


    pub_type: 杂志文章


    authors: Goldstein ND,Newbern EC,Evans AA,Drezner K,Welles SL

    更新日期:2015-07-31 00:00:00

  • Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system.

    abstract::A formulation of recombinant hepatitis B surface antigen (HBsAg) combined with a novel adjuvant system, SBAS4--a combination of aluminium salt and monophosphoryl lipid A (MPL), was assessed in 27 healthy adult volunteers with a commercial vaccine (Engerix-B) as control. After three doses (0, 1, 6 months schedule), rea...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thoelen S,Van Damme P,Mathei C,Leroux-Roels G,Desombere I,Safary A,Vandepapeliere P,Slaoui M,Meheus A

    更新日期:1998-04-01 00:00:00

  • Influenza and pertussis vaccination in pregnancy: Portrayal in online media articles and perceptions of pregnant women and healthcare professionals.

    abstract:INTRODUCTION:Online media may influence women's decision to undergo vaccination during pregnancy. The aims of this mixed-methods study were to: (1) examine the portrayal of maternal vaccination in online media and (2) establish the perceived target of vaccine protection as viewed by pregnant women and maternity healthc...


    pub_type: 杂志文章


    authors: Wilcox CR,Bottrell K,Paterson P,Schulz WS,Vandrevala T,Larson HJ,Jones CE

    更新日期:2018-11-29 00:00:00

  • Clinical experience with inactivated, virosomal influenza vaccine.

    abstract::Current available influenza vaccines are safe and effective in preventing influenza. Nevertheless, there is a need for influenza vaccines with improved efficacy in the elderly. This need is underscored by both the observation that influenza has a major clinical and economic impact in the elderly and the fact that curr...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Bruijn IA,Nauta J,Cramer WC,Gerez L,Palache AM

    更新日期:2005-07-08 00:00:00

  • Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant.

    abstract::Aluminium-containing adjuvants are often used to enhance the potency of vaccines. In the present work we studied whether adsorption of diphtheria toxoid to colloidal aluminium hydroxide induces conformational changes of the antigen. Diphtheria toxoid has a high affinity for the aluminium hydroxide particles based on a...


    pub_type: 杂志文章


    authors: Régnier M,Metz B,Tilstra W,Hendriksen C,Jiskoot W,Norde W,Kersten G

    更新日期:2012-11-06 00:00:00

  • Carrier-dependent specificity of antibodies to a conserved peptide determinant of gp120.

    abstract::Amino acid residues 421-436 constitute a comparatively conserved determinant of gp120 that participates in the binding of host cell CD4 receptors by HIV-1. We compared the immunogenicity of synthetic Cys-gp120 (421-436) conjugated to KLH via the N terminal Cys residue (KLH-I) and gp120 (421-436) extended at its N term...


    pub_type: 杂志文章


    authors: Karle S,Nishiyama Y,Taguchi H,Zhou YX,Luo J,Planque S,Hanson C,Paul S

    更新日期:2003-03-07 00:00:00

  • The PGRS domain of Mycobacterium tuberculosis PE_PGRS Rv1759c antigen is an efficient subunit vaccine to prevent reactivation in a murine model of chronic tuberculosis.

    abstract::A third of the world population is latently infected with Mycobacterium tuberculosis and many cases of active tuberculosis arise from latent bacilli reactivation. Thus, it is important to design new vaccines to prevent reactivation. Using an experimental model of chronic tuberculosis in B6D2F1 mice, we observed consta...


    pub_type: 杂志文章


    authors: Campuzano J,Aguilar D,Arriaga K,León JC,Salas-Rangel LP,González-y-Merchand J,Hernández-Pando R,Espitia C

    更新日期:2007-05-04 00:00:00

  • Neurovirulence tests of type 3 oral poliovirus vaccine manufactured by Lederle Laboratories, 1964-1988.

    abstract::Oral poliovirus vaccine (OPV) is tested for safety by evaluation of neurovirulence in rhesus and cynomolgus macaques. After intraspinal or intrathalamic injection of varying doses of vaccine, monkeys are followed for 17-21 days, killed, and a histopathological evaluation is made of the severity of poliomyelitis lesion...


    pub_type: 杂志文章


    authors: Nathanson N,Horn SD

    更新日期:1992-01-01 00:00:00

  • Ultraviolet-C irradiation for inactivation of viruses in foetal bovine serum.

    abstract::Foetal Bovine Serum (FBS) and porcine trypsin are one of the essential raw materials used in the manufacturing of cell culture based viral vaccines. Being from animal origin, these raw materials can potentially contaminate the final product by known or unknown adventitious agents. The issue is more serious in case of ...


    pub_type: 杂志文章


    authors: Vaidya V,Dhere R,Agnihotri S,Muley R,Patil S,Pawar A

    更新日期:2018-07-05 00:00:00

  • The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is a highly protective antigen against serotype 2.

    abstract::Streptococcus suis (S. suis) is a major porcine pathogen causing meningitis, arthritis and several other pathologies. Recently, we identified a highly specific immunoglobulin M degrading enzyme of S. suis, designated IdeSsuis, which is expressed by various serotypes. The objective of this work was to access the immuno...


    pub_type: 杂志文章


    authors: Seele J,Hillermann LM,Beineke A,Seitz M,von Pawel-Rammingen U,Valentin-Weigand P,Baums CG

    更新日期:2015-05-05 00:00:00

  • Intervention effects from a social marketing campaign to promote HPV vaccination in preteen boys.

    abstract:OBJECTIVES:Adoption of human papillomavirus (HPV) vaccination in the US has been slow. In 2011, HPV vaccination of boys was recommended by CDC for routine use at ages 11-12. We conducted and evaluated a social marketing intervention with parents and providers to stimulate HPV vaccination among preteen boys. METHODS:We...


    pub_type: 杂志文章


    authors: Cates JR,Diehl SJ,Crandell JL,Coyne-Beasley T

    更新日期:2014-07-16 00:00:00

  • Sequence constancies and variations in genes encoding three new meningococcal vaccine candidate antigens.

    abstract::By the strategy "reverse vaccinology" a number of new antigens have been identified in Neisseria meningitidis, which are potential candidates for a highly needed broad-spectrum meningococcal vaccine. In the present study we examined the prevalence, sequence constancies and variations of the genes encoding three of the...


    pub_type: 杂志文章


    authors: Jacobsson S,Thulin S,Mölling P,Unemo M,Comanducci M,Rappuoli R,Olcén P

    更新日期:2006-03-15 00:00:00

  • Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS).

    abstract::Vaccination is the principal means used to control and treat porcine reproductive and respiratory syndrome virus (PRRSV) infection. An array of PRRS vaccine products is available in various regions of the world. However, despite extensive efforts, little progress has been made to improve efficacy since the first intro...


    pub_type: 杂志文章,评审


    authors: Murtaugh MP,Genzow M

    更新日期:2011-10-26 00:00:00

  • Lack of immune interference between inactivated polio vaccine and inactivated rotavirus vaccine co-administered by intramuscular injection in two animal species.

    abstract::A parenteral inactivated rotavirus vaccine (IRV) in development could address three problems with current live oral rotavirus vaccines (ORV): their lower efficacy in low and middle-income countries (LMICs), lingering concerns about their association with intussusception, and their requirement for a separate supply cha...


    pub_type: 杂志文章


    authors: Wang Y,Zade J,Moon SS,Weldon W,Pisal SS,Glass RI,Dhere RM,Jiang B

    更新日期:2019-01-29 00:00:00

  • Influenza vaccination coverage one year after the A(H1N1) influenza pandemic, France, 2010-2011.

    abstract::We report influenza vaccination coverage in target groups for the 2010-2011 influenza season, one year after the A(H1N1) pandemic. Data were collected through a one-stage cross-sectional national random telephone survey conducted in January 2011 among a sample of the population of mainland France connected to a land t...


    pub_type: 杂志文章


    authors: Guthmann JP,Fonteneau L,Bonmarin I,Lévy-Bruhl D

    更新日期:2012-02-01 00:00:00

  • Immunogenicity of an alum-adsorbed synthetic multiple-antigen peptide based on B- and T-cell epitopes of the Plasmodium falciparum CS protein: possible vaccine application.

    abstract::Multiple-antigen peptides (MAPs), containing B- and T-cell epitopes of the Plasmodium falciparum circumsporozoite (CS) protein, have been designed to overcome the limitations of first-generation peptide vaccines caused by low epitope density, carrier toxicity and the lack of parasite-derived T-cell epitopes. The immun...


    pub_type: 杂志文章


    authors: de Oliveira GA,Clavijo P,Nussenzweig RS,Nardin EH

    更新日期:1994-08-01 00:00:00

  • Hyporesponsiveness to re-challenge dose following pneumococcal polysaccharide vaccine at 12 months of age, a randomized controlled trial.

    abstract:BACKGROUND:To evaluate the immunological impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPS) at 12 months, for children who have received zero to three infant doses of seven-valent pneumococcal conjugate vaccine (PCV), on responses to a subsequent exposure to a small dose of 23vPPS (mPPS). METHODS:Fiv...


    pub_type: 杂志文章,随机对照试验


    authors: Russell FM,Carapetis JR,Balloch A,Licciardi PV,Jenney AW,Tikoduadua L,Waqatakirewa L,Pryor J,Nelson J,Byrnes GB,Cheung YB,Tang ML,Mulholland EK

    更新日期:2010-04-26 00:00:00

  • Modeling the cost-effectiveness of maternal acellular pertussis immunization (aP) in different socioeconomic settings: A dynamic transmission model of pertussis in three Brazilian states.

    abstract:OBJECTIVES:Using dynamic transmission models we evaluated the health and cost outcomes of adding acellular pertussis (aP) vaccination of pregnant women to infant vaccination in three Brazilian states that represent different socioeconomic conditions. The primary objective was to determine whether the same model structu...


    pub_type: 杂志文章


    authors: Luz PM,Struchiner CJ,Kim SY,Minamisava R,Andrade ALS,Sanderson C,Russell LB,Toscano CM

    更新日期:2021-01-03 00:00:00

  • Use of mobile phones for improving vaccination coverage among children living in rural hard-to-reach areas and urban streets of Bangladesh.

    abstract::In Bangladesh, full vaccination rates among children living in rural hard-to-reach areas and urban streets are low. We conducted a quasi-experimental pre-post study of a 12-month mobile phone intervention to improve vaccination among 0-11 months old children in rural hard-to-reach and urban street dweller areas. Softw...


    pub_type: 杂志文章


    authors: Uddin MJ,Shamsuzzaman M,Horng L,Labrique A,Vasudevan L,Zeller K,Chowdhury M,Larson CP,Bishai D,Alam N

    更新日期:2016-01-04 00:00:00

  • Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein.

    abstract::Dynamic studies of influenza virus infection in the live cells are limited because of the lack of appropriate methods for non-invasive detection of the viral components. Using the split-GFP strategy, we have recently developed and characterized an unimpaired recombinant influenza A virus encoding a tagged PB2 subunit ...


    pub_type: 杂志文章


    authors: Avilov SV,Moisy D,Naffakh N,Cusack S

    更新日期:2012-12-07 00:00:00

  • Effectiveness of Jeryl Lynn-containing vaccine in Spanish children.

    abstract::We evaluated the effectiveness of the Jeryl Lynn strain vaccine in a large outbreak of mumps in Navarre, Spain, 2006-2008. Each of the 241 cases of mumps occurring in children over 15 months of age born between 1998 and 2005 was compared with 5 controls individually matched by sex, birth date, district of residence an...


    pub_type: 杂志文章


    authors: Castilla J,García Cenoz M,Arriazu M,Fernández-Alonso M,Martínez-Artola V,Etxeberria J,Irisarri F,Barricarte A

    更新日期:2009-03-26 00:00:00

  • Comparison of platform technologies for assaying antibody to Ebola virus.

    abstract:BACKGROUND:The recent Ebola outbreak in West Africa led to the use of a variety of different platform technologies for assaying antibodies because of the difficulties of handling the live virus. The same types of method could be applied rapidly to other infections when they emerge. There is a need to compare quantitati...


    pub_type: 杂志文章


    authors: Wilkinson DE,Page M,Mattiuzzo G,Hassall M,Dougall T,Rigsby P,Stone L,Minor P

    更新日期:2017-03-01 00:00:00

  • Enhancement of the protective efficacy of a Chlamydia trachomatis recombinant vaccine by combining systemic and mucosal routes for immunization.

    abstract::Chlamydia trachomatis causes respiratory and sexually transmitted infections. Here, we tested a vaccine formulated with the recombinant major outer membrane protein from C. trachomatis mouse pneumonitis (CT-MoPn) for its ability to protect mice against an intranasal (i.n.) challenge. The adjuvants CpG and Montanide we...


    pub_type: 杂志文章


    authors: Ralli-Jain P,Tifrea D,Cheng C,Pal S,de la Maza LM

    更新日期:2010-11-10 00:00:00

  • Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates.

    abstract::The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than f...


    pub_type: 杂志文章


    authors: Ohara N,Matsuoka M,Nomaguchi H,Naito M,Yamada T

    更新日期:2001-02-28 00:00:00

  • Molecular epidemiology of tick-borne encephalitis virus: cross-protection between European and Far Eastern subtypes.

    abstract::Tick-borne encephalitis virus isolates from widely separated geographic regions of the USSR, six isolates from Hungary and one from France were compared with the European and Far Eastern prototype viruses. Peptide mapping by limited proteolysis yielded similar patterns for five selected isolates from the USSR. All iso...


    pub_type: 杂志文章


    authors: Holzmann H,Vorobyova MS,Ladyzhenskaya IP,Ferenczi E,Kundi M,Kunz C,Heinz FX

    更新日期:1992-01-01 00:00:00

  • Estimating the effect of measles vaccination on child growth using 191 DHS from 65 low- and middle-income countries.

    abstract:BACKGROUND:Childhood vaccinations reduce morbidity and mortality and are highly cost-effective. They may also protect children from malnutrition and lead to improved child growth. Stunting, wasting and underweight are targets used to monitor progress towards the achievement of the sustainable development goals (SDGs). ...


    pub_type: 杂志文章


    authors: Bogler L,Jantos N,Bärnighausen T,Vollmer S

    更新日期:2019-08-14 00:00:00

  • IMP321 (sLAG-3) safety and T cell response potentiation using an influenza vaccine as a model antigen: a single-blind phase I study.

    abstract::sLAG-3 (IMP321), a natural high affinity ligand for MHC class II, was tested for safety, tolerability and its ability to increase Th-1-type T cell responses to a commercial trivalent split influenza vaccine (Agrippal) in a phase I single-blinded, randomized, controlled clinical trial. Twenty healthy volunteers were fi...


    pub_type: 杂志文章,随机对照试验


    authors: Brignone C,Grygar C,Marcu M,Perrin G,Triebel F

    更新日期:2007-06-11 00:00:00

  • Inclusion of the value of herd immunity in economic evaluations of vaccines. A systematic review of methods used.

    abstract:OBJECTIVE:The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. METHODS:We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additi...


    pub_type: 杂志文章,评审


    authors: Nymark LS,Sharma T,Miller A,Enemark U,Griffiths UK

    更新日期:2017-12-14 00:00:00

  • Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine.

    abstract::The current human whole-cell vaccine is ineffective against pneumonic plague caused by typical F1 capsule positive (F1+) strains of Yersinia pestis. The authors found this vaccine to also be ineffective against F1-negative (F1-) Y. pestis strains, which have been isolated from a human case and from rodents. For these ...


    pub_type: 杂志文章


    authors: Heath DG,Anderson GW Jr,Mauro JM,Welkos SL,Andrews GP,Adamovicz J,Friedlander AM

    更新日期:1998-07-01 00:00:00