Abstract:
BACKGROUND:Vaccinations are an effective choice to stop disease outbreaks, including COVID-19. There is little research on individuals' COVID-19 vaccination decision-making. OBJECTIVE:We aimed to determine individual preferences for COVID-19 vaccinations in China, and to assess the factors influencing vaccination decision-making to facilitate vaccination coverage. METHODS:A D-efficient discrete choice experiment was conducted across six Chinese provinces selected by the stratified random sampling method. Vaccine choice sets were constructed using seven attributes: vaccine effectiveness, side-effects, accessibility, number of doses, vaccination sites, duration of vaccine protection, and proportion of acquaintances vaccinated. Conditional logit and latent class models were used to identify preferences. RESULTS:Although all seven attributes were proved to significantly influence respondents' vaccination decision, vaccine effectiveness, side-effects and proportion of acquaintances vaccinated were the most important. We also found a higher probability of vaccinating when the vaccine was more effective; risks of serious side effects were small; vaccinations were free and voluntary; the fewer the number of doses; the longer the protection duration; and the higher the proportion of acquaintances vaccinated. Higher local vaccine coverage created altruistic herd incentives to vaccinate rather than free-rider problems. The predicted vaccination uptake of the optimal vaccination scenario in our study was 84.77%. Preference heterogeneity was substantial. Individuals who were older, had a lower education level, lower income, higher trust in the vaccine and higher perceived risk of infection, displayed a higher probability to vaccinate. CONCLUSIONS:Preference heterogeneity among individuals should lead health authorities to address the diversity of expectations about COVID-19 vaccinations. To maximize COVID-19 vaccine uptake, health authorities should promote vaccine effectiveness; pro-actively communicate the absence or presence of vaccine side effects; and ensure rapid and wide media communication about local vaccine coverage.
journal_name
Vaccinejournal_title
Vaccineauthors
Leng A,Maitland E,Wang S,Nicholas S,Liu R,Wang Jdoi
10.1016/j.vaccine.2020.12.009subject
Has Abstractpub_date
2021-01-08 00:00:00pages
247-254issue
2eissn
0264-410Xissn
1873-2518pii
S0264-410X(20)31576-0journal_volume
39pub_type
杂志文章相关文献
VACCINE文献大全abstract::The highly pathogenic avian influenza (HPAI) H5N1 viruses and their spillover into the human population pose substantial economic and public health threats. Although antiviral drugs have some effect in treating influenza infection, vaccination is still the most effective intervention to prevent possible pandemic outbr...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.01.051
更新日期:2020-02-28 00:00:00
abstract::At present, the seed viruses for the manufacture of licensed seasonal inactivated influenza vaccines in the United States are derived from primary egg isolates as a result of concerns associated with adventitious agents. According to the prevailing view, the passage of influenza viruses through eggs serves as a filter...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.02.041
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND AND PURPOSE:Varicella disease is a risk factor for pediatric Arterial Ischemic Stroke (AIS). Isolated case reports have emerged suggesting that varicella vaccination may also pose a risk for AIS. METHODS:This retrospective population-based cohort study assessed the risk of AIS in children who received a var...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.04.012
更新日期:2018-05-11 00:00:00
abstract::Life has its problems. To succeed it has to survive: to survive it has to sacrifice its identity. And viruses have their fingers in the essence of it all. Consider the situation. There are useful genes. Such genes promote the survival of the individuals which house them. It is not unreasonable, therefore, to expect th...
journal_title:Vaccine
pub_type: 社论
doi:10.1016/0264-410x(91)90002-n
更新日期:1991-12-01 00:00:00
abstract::Intramuscular immunization of mice with DNA cocktail vaccines, comprising potential protective antigens P36, P46, NrdF, and P97or P97R1 of Mycoplasma hyopneumoniae, induced strong Th1-polarized immune responses against each antigen, with only P46 eliciting a serum IgG response. Subcutaneous immunization with protein c...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.06.005
更新日期:2008-08-12 00:00:00
abstract::Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2015.07.059
更新日期:2015-10-13 00:00:00
abstract::Sera were taken over a 5 year period from Gambian children vaccinated in 1983, when aged 1-4 years, with A + C meningococcal capsular polysaccharide, ELISA tests were devised to determine the concentrations of immunoglobulin A, G and M reacting with A polysaccharide and of IgG reacting with Opc protein, IgA1 protease ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(96)00138-7
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:To block transmission of measles, the China Ministry of Health endorsed the "2006-2012 National Measles Elimination Action Plan (NMEAP)" on November 11, 2006, while no published studies used mathematical models to assess the impact of this action. Also, the problem of residuals autocorrelation due to auto-co...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.04.053
更新日期:2020-06-09 00:00:00
abstract::Development of effective new mucosal vaccine adjuvants has become a priority with the increase in emerging viral and bacterial pathogens. We previously reported that cationic liposomes complexed with non-coding plasmid DNA (CLDC) were effective parenteral vaccine adjuvants. However, little is known regarding the abili...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.05.009
更新日期:2011-07-18 00:00:00
abstract::Flagellin of Pseudomonas aeruginosa is an important vaccine candidate. N-terminal domains are highly conserved in both type a and type b flagellins. The efficacy of gold nanoparticles (AuNPs) conjugated to N-terminal domains of P. aeruginosa flagellin (flagellin(1-161)), as an immunogen in mice, has been assessed. The...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.01.041
更新日期:2016-03-14 00:00:00
abstract::Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length E were immunogenic...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(99)00570-8
更新日期:2000-05-08 00:00:00
abstract::Codon-pair bias de-optimization (CPBD) of viruses involves re-writing viral genes using statistically underrepresented codon pairs, without any changes to the amino acid sequence or codon usage. Previously, this technology has been used to attenuate the influenza A/Puerto Rico/8/34 (H1N1) virus. The de-optimized virus...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.11.054
更新日期:2016-01-20 00:00:00
abstract::Despite a critical need for a respiratory syncytial virus (RSV) vaccine and decades of development efforts, a vaccine to protect infants, elderly, and other at-risk populations from RSV infection remains elusive. We have previously generated a new, live-attenuated vaccine candidate against RSV using rational, computer...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.02.056
更新日期:2020-03-23 00:00:00
abstract::In the present study, cross-protection to bovine herpesvirus type 5 (BHV-5) induced by bovine herpesvirus type 1 (BHV-1) vaccination was examined following inoculation of rabbits and calves with a glycoprotein E (gE)-negative BHV-1 vaccine and subsequent challenge with BHV-5. Rabbits (n=5) and calves (n=8) were vaccin...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.01.024
更新日期:2006-04-12 00:00:00
abstract::In Autumn 1990, trivalent split influenza virus vaccine containing A/Taiwan/1/86(H1N1) was used to immunize healthy female employees (n = 104). The 11-12 amino acid differences in the HA1 domain of virus haemagglutinin between A/Taiwan/1/86 and representative epidemic H1N1 strains in Finland in 1991 did not result in ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90126-i
更新日期:1993-01-01 00:00:00
abstract::Lyme disease is a major human health problem which continues to increase in incidence and geographic distribution. As a vector-borne zoonotic disease, Lyme disease may be amenable to reservoir targeted strategies for control. We have previously reported that a vaccinia virus (VV) based vaccine expressing outer surface...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.07.100
更新日期:2011-10-13 00:00:00
abstract::As part of a larger study exploring how European citizens' balance issues of public and private interest and the extent to which they are prepared to accept State intervention on a range of public health issues, focus group participants were asked whether childhood immunisation should be a matter of parental choice or...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.11.001
更新日期:2008-01-17 00:00:00
abstract::Information provided by most influenza vaccine manufacturers do not reflect the recommendations of WHO and/or national public health advisory groups with regard to the use of influenza vaccines in pregnant or lactating women. The majority of vaccines contain precautionary language which could discourage use in pregnan...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2016.08.042
更新日期:2016-10-26 00:00:00
abstract:BACKGROUND:Cervical cancer is one of the most prevalent cancers in women caused by the human papillomavirus (HPV) that leads to a substantial disease burden for health systems. Prevention through vaccination can significantly reduce the prevalence of cervical cancer. The objective of this study is to evaluate the poten...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.10.037
更新日期:2020-01-10 00:00:00
abstract::Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and vaccination is the primary tool for the disease control. Previously, we developed a more cost-effective PCV2 virus-like particle (VLP) vaccine by using ELPylation technology. In the present study, we compared the ELPylated VLP (ELP-VLP) P...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.03.060
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:US-bound refugees undergo required health assessments overseas to identify and treat communicable diseases of public health significance-such as pulmonary tuberculosis-before migration. Immunizations are not required, leaving refugees at risk for vaccine-preventable diseases. In response, the US Centers for ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.10.047
更新日期:2021-01-03 00:00:00
abstract::Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.07.101
更新日期:2017-09-12 00:00:00
abstract::One hundred and fourteen children, born to HBsAg-positive mothers received in the first year of life passive active prophylaxis for hepatitis B virus (HBV). They have been followed up to 10 years. A booster dose given in a cohort at the 5th year does not seem to increase protection against HBV. No difference in immuno...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)00028-5
更新日期:1997-08-01 00:00:00
abstract::The ability of Escherichia coli heat-labile enterotoxin (LT) to influence the induction and maintenance of tolerance was examined in animals primed orally with a soluble protein antigen, ovalbumin (OVA), or in animals primed orally with two unrelated protein antigens administered simultaneously, OVA and bovine serum a...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(88)90223-x
更新日期:1988-06-01 00:00:00
abstract::Delayed-type hypersensitivity (DTH) response to arthropod vector salivary proteins is associated with protection against pathogen transmission. Massive cDNA sequencing, high-throughput DNA plasmid construction and DNA immunisation were used to identify twelve DTH inducing proteins isolated from a Phlebotomus ariasi sa...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.07.085
更新日期:2006-01-16 00:00:00
abstract::We investigated the influence of the site of administration of DNA vaccine on the induced immune response. DNA vaccines were administered by electroporation at three different sites: tibial cranial muscle, abdominal skin and ear pinna. Aiming to draw general conclusions about DNA vaccine delivery, we successively used...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.05.005
更新日期:2015-06-22 00:00:00
abstract::The objective of this investigation was to analyze conditions leading to antibody responses against innocuous dietary protein antigens in the chick. The physical form of antigen was found to be important for immunization of mature chicks: bovine serum albumin (BSA) in solution was a powerful immunogen, while BSA powde...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(00)00557-0
更新日期:2001-04-06 00:00:00
abstract:INTRODUCTION:Two types of Japanese encephalitis (JE) vaccines, inactivated JE vaccine (JE-I) and live-attenuated JE vaccine (JE-L), are available and used in China. In particular, one JE-L, produced by a domestic manufacturer in China, was prequalified by WHO in 2013. We assessed the safety of JE vaccines in China duri...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.05.021
更新日期:2017-06-22 00:00:00
abstract::Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was tested in this stu...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.11.003
更新日期:2006-03-15 00:00:00
abstract::Availability of new rotavirus vaccines highlights the need to maintain and enhance rotavirus strain surveillance. We collected stool samples from children with gastroenteritis admitted to eight hospitals in South Korea from April 2005 to March 2007. Of the 6057 samples collected, 1337 (22%) were positive for rotavirus...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.09.002
更新日期:2009-11-20 00:00:00