HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis.

Abstract:

:The conventional treatment for paracoccidioidomycosis, the most prevalent mycosis in Latin America, involves long periods of therapy resulting in sequels and high frequency of relapses. The search for new alternatives of treatment is necessary. Previously, we have demonstrated that the hsp65 gene from Mycobacterium leprae shows prophylactic effects against murine paracoccidioidomycosis. Here, we tested the DNAhsp65 immunotherapy in BALB/c mice infected with Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. We observed an increase of Th1 cytokines accompanied by a reduction in fungal burden and pulmonary injury. These results provide new prospects for immunotherapy of paracoccidioidomycosis and other mycoses.

journal_name

Vaccine

journal_title

Vaccine

authors

Ribeiro AM,Bocca AL,Amaral AC,Souza AC,Faccioli LH,Coelho-Castelo AA,Figueiredo F,Silva CL,Felipe MS

doi

10.1016/j.vaccine.2009.11.062

subject

Has Abstract

pub_date

2010-02-10 00:00:00

pages

1528-34

issue

6

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)01865-9

journal_volume

28

pub_type

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