当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques.

Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques.

Abstract：

:The human adenovirus type 19a/64 (hAd19a) is a rare serotype in the human population that transduces human dendritic cells (DCs) and human muscle cells more efficiently than the well-characterized human adenovirus type 5 (hAd5). To further characterize the potential of this vector as a vaccine we designed replication deficient hAd19a, hAd5 and MVA vectors expressing a papillomavirus (PV) antigen fused to the human MHC class II associated invariant chain T cell adjuvant (hIi) and investigated their immunogenicity in vivo in mice and cynomolgus macaques. We initially showed that the hIi encoded in the hAd5 enhanced PV specific CD8+ T cell responses in mice. The T cell responses induced after hAd19a vaccination was similar to those induced by hAd5 vaccination. The hAd19a induced responses were not reduced in presence of preexisting Ad5 immunity in mice. In macaques both vaccines were equally potent at inducing CD8+ T cells after MVA boost, while the level of CD4+ T cell responses were found to be broader in hAd19a primed animals. These data demonstrate the potential of hAd19a as an alternative vector to hAd5 to elicit potent T cell responses to PV.

journal_name

Vaccine

journal_title

Vaccine

authors

Ragonnaud E,Schroedel S,Mariya S,Iskandriati D,Pamungkas J,Fougeroux C,Daradoumis J,Thomsen AR,Neukirch L,Ruzsics Z,Salomon M,Thirion C,Holst PJ

doi

10.1016/j.vaccine.2018.07.075

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

6212-6222

issue

41

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(18)31095-8

journal_volume

36

pub_type

杂志文章

相关文献

VACCINE文献大全
  • One-year study of the 2-1-1 intramuscular postexposure rabies vaccine regimen in 100 severely exposed Thai patients using rabies immune globulin and Vero cell rabies vaccine.

    abstract：:The 2-1-1 rabies postexposure treatment schedule is an abbreviated regimen in which a tissue culture rabies vaccine is administered intramuscularly at two sites on day 0, and at one site on days 7 and 21. Compared to the standard five-dose intramuscular regimen, the 2-1-1 schedule reduces the number of clinic visits f...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(91)90244-z

    authors： Chutivongse S,Wilde H,Fishbein DB,Baer GM,Hemachudha T

    更新日期：1991-08-01 00:00:00

  • In vivo evidence of immunological masking of the Vibrio cholerae O antigen of a hybrid Salmonella typhi Ty21a-Vibrio cholerae oral vaccine in humans.

    abstract：:The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and chol...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0264-410x(91)90039-9

    authors： Forrest BD,LaBrooy JT

    更新日期：1991-07-01 00:00:00

  • Amended recombinant cells (ARCs) expressing bovine IFN-gamma: an economical and highly effective adjuvant system.

    abstract：:Interferon-gamma (IFN-gamma) has potent immune stimulatory activity, but purifying recombinant protein is expensive, soluble cytokine delivery is inefficient, and high doses of IFN-gamma cause adverse systemic effects. We've shown, however, that chemically fixed, amended recombinant Pseudomonas fluorescens cells (ARCs...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.12.049

    authors： Gaertner FH,Babiuk LA,Mutwiri G,Armstrong JM,Griebel PJ

    更新日期：2009-02-25 00:00:00

  • Enhancing immune responses to inactivated porcine parvovirus oil emulsion vaccine by co-inoculating porcine transfer factor in mice.

    abstract：:Inactivated porcine parvovirus (PPV) vaccines are available commercially and widely used in the breeding herds. However, inactivated PPV vaccines have deficiencies in induction of specific cellular immune response. Transfer factor (TF) is a material that obtained from the leukocytes, and is a novel immune-stimulatory ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.077

    authors： Wang RN,Wang YB,Geng JW,Guo DH,Liu F,Chen HY,Zhang HY,Cui BA,Wei ZY

    更新日期：2012-07-27 00:00:00

  • An assessment of parents' childhood immunization beliefs, intentions, and behaviors using a smartphone panel.

    abstract：INTRODUCTION:It is important to quickly identify parent beliefs, intentions, and behaviors toward childhood vaccination, especially parents of children 19 to 35 months. This paper describes parental immunization beliefs, intentions, and behaviors; assesses the relationships between beliefs and intentions regarding chil...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.01.032

    authors： Boyle J,Berman L,Nowak GJ,Iachan R,Middleton D,Deng Y

    更新日期：2020-02-28 00:00:00

  • Vaccination with human papillomavirus type 16-derived peptides using a tattoo device.

    abstract：:Tattooing has been shown to be very efficient at inducing immunity by vaccination with DNA vaccines. In this study, we examined the usability of tattooing for delivery of peptide vaccines. We compared tattooing with subcutaneous (s.c.) needle injection using peptides derived from human papillomavirus type 16 (HPV16) p...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.03.073

    authors： Pokorná D,Poláková I,Kindlová M,Dusková M,Ludvíková V,Gabriel P,Kutinová L,Müller M,Smahel M

    更新日期：2009-06-02 00:00:00

  • Novel lipopeptides of ESAT-6 induce strong protective immunity against Mycobacterium tuberculosis: Routes of immunization and TLR agonists critically impact vaccine's efficacy.

    abstract：:Mycobacterium tuberculosis (Mtb), the bacterial cause of tuberculosis, is a leading infectious agent worldwide. The development of a new vaccine against Mtb is essential to control global spread of tuberculosis, since the current vaccine BCG is not very effective and antibiotic resistance is a serious, burgeoning prob...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.08.075

    authors： Gupta N,Vedi S,Kunimoto DY,Agrawal B,Kumar R

    更新日期：2016-11-04 00:00:00

  • Chapter 15: HPV vaccine use in the developing world.

    abstract：:Human papillomavirus (HPV)-related morbidity and mortality from cervical cancer primarily occurs in the developing world, where, unfortunately, access to vaccines in general, and expensive newer vaccines in particular, is often more limited than in the industrialized world. In addition, secondary prevention methods su...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2006.05.128

    authors： Kane MA,Sherris J,Coursaget P,Aguado T,Cutts F

    更新日期：2006-08-31 00:00:00

  • Age-related immunogenicity and reactogenicity of live oral cholera vaccine CVD 103-HgR in a randomized, controlled clinical trial.

    abstract：:Aging is accompanied by a decline in immune function which can lead to decreased responses to vaccines. Attenuated recombinant Vibrio cholerae O1 vaccine strain CVD 103-HgR elicits a rapid serum vibriocidal antibody (SVA) response and protects against cholera diarrhea in volunteer challenge studies but has not been st...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2019.01.077

    authors： McCarty JM,Lock MD,Bennett S,Hunt KM,Simon JK,Gurwith M

    更新日期：2019-03-07 00:00:00

  • A new oral vaccine candidate based on the microencapsulation by spray-drying of inactivated Vibrio cholerae.

    abstract：:The aim of this work was to evaluate the microencapsulation by spray-drying of inactivated Vibrio cholerae, using methacrylic copolymers Eudragit® L30D-55 and FS30D. The microparticles obtained presented a particle size around 3.0 μm. The preparation temperature affected the morphology and the antigenicity of micropar...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.05.098

    authors： Año G,Esquisabel A,Pastor M,Talavera A,Cedré B,Fernández S,Sifontes S,Aranguren Y,Falero G,García L,Solís RL,Pedraz JL

    更新日期：2011-08-05 00:00:00

  • The Health Belief Model in predicting healthcare workers' intention for influenza vaccine uptake in Jordan.

    abstract：BACKGROUND:Theories of health behavior change are being inadequately adopted to understand the reasons behind low influenza vaccination rates among healthcare workers (HCWs). The Theory of Planned Behavior (TPB) is being used to predict intention-behavior relationship while the Health Belief Model (HBM) is being employ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.09.002

    authors： Alhalaseh L,Fayoumi H,Khalil B

    更新日期：2020-10-27 00:00:00

  • Protection against tetanus toxin after intragastric administration of two recombinant lactic acid bacteria: impact of strain viability and in vivo persistence.

    abstract：:Non-pathogenic lactic acid bacteria (LAB) are attractive as live carriers to deliver protective antigens to the mucosal immune system. Both persisting and non-persisting strains of lactic acid bacteria have been evaluated and seem to work equally well by the systemic and nasal routes of administration. However, it is ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00301-8

    authors： Grangette C,Müller-Alouf H,Geoffroy M,Goudercourt D,Turneer M,Mercenier A

    更新日期：2002-09-10 00:00:00

  • Immunopathological responses and kinetics of Brucella melitensis Rev 1 infection after subcutaneous or conjunctival vaccination in rams.

    abstract：:The innocuousness of the Brucella melitensis Rev 1 live attenuated vaccine strain has never been fully assessed in rams. The immunopathological responses and the kinetics and distribution of the infection induced by this strain were determined after subcutaneous or conjunctival vaccination in both young (3-4 months ol...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.03.030

    authors： Muñoz PM,de Miguel MJ,Grilló MJ,Marín CM,Barberán M,Blasco JM

    更新日期：2008-05-19 00:00:00

  • HIV subtypes and recombination strains--strategies for induction of immune responses in man.

    abstract：:Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor-ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular rece...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(02)00084-1

    authors： Wahren B,Ljungberg K,Rollman E,Levi M,Zuber B,Kjerrström Zuber A,Hinkula J,Leandersson AC,Calarota S,Hejdeman B,Bratt G,Sandström E

    更新日期：2002-05-06 00:00:00

  • Efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RV5) in healthy Chinese infants: A randomized, double-blind, placebo-controlled trial.

    abstract：BACKGROUND:A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RotaTeq™, RV5) against rotavirus gastroenteritis (RVGE). METHODS:4040 participants aged 6-12weeks were...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2017.08.081

    authors： Mo Z,Mo Y,Li M,Tao J,Yang X,Kong J,Wei D,Fu B,Liao X,Chu J,Qiu Y,Hille DA,Nelson M,Kaplan SS

    更新日期：2017-10-13 00:00:00

  • Similar long-term vaccine efficacy of two versus three doses of HBV vaccine in early life.

    abstract：:WHO currently recommends three vaccinations against hepatitis B to provide optimal protection against infection and carriage. However, immunological theory and mathematical modelling suggest that similar protection could be induced with two doses, and trials among adolescents and adults have shown comparable rates for...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.10.023

    authors： van der Sande MA,Mendy M,Waight P,Doherty C,McConkey SJ,Hall AJ,Whittle HC

    更新日期：2007-02-09 00:00:00

  • Hospital-based surveillance and molecular epidemiology of rotavirus infection in Taiwan, 2005-2007.

    abstract：:To determine the distribution of rotavirus strains and facilitate vaccine policy decisions in Taiwan, active hospital-based gastroenteritis surveillance was conducted in three sentinel hospitals. From 1 January 2005 to 31 December 2007, a total of 3435 children less than 5 years old with gastroenteritis were enrolled....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.08.090

    authors： Wu FT,Liang SY,Tsao KC,Huang CG,Lin CY,Lin JS,Su CY,Eng HL,Yang JY,Chen PJ,Yang CF

    更新日期：2009-11-20 00:00:00

  • Brucella abortusΔcydCΔcydD and ΔcydCΔpurD double-mutants are highly attenuated and confer long-term protective immunity against virulent Brucella abortus.

    abstract：:We constructed double deletion (ΔcydCΔcydD and ΔcydCΔpurD) mutants from virulent Brucella abortus biovar 1 field isolate (BA15) by deleting the genes encoding an ATP-binding cassette-type transporter (cydC and cydD genes) and a phosphoribosylamine-glycine ligase (purD). Both BA15ΔcydCΔcydD and BA15ΔcydCΔpurD double-mu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.11.030

    authors： Truong QL,Cho Y,Park S,Kim K,Hahn TW

    更新日期：2016-01-04 00:00:00

  • Applications of bioinformatics and computational biology to influenza surveillance and vaccine strain selection.

    abstract：:In recent years, collaborations often between mathematical and computational biologists and scientists in the World Health Organization (WHO) global influenza surveillance network, have resulted in a number of mathematical and computational advances including: increasing the resolution at which antigenic surveillance ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00068-9

    authors： Smith DJ

    更新日期：2003-05-01 00:00:00

  • Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination.

    abstract：:The World Health Organization's Expanded Programme on Immunization has led to a dramatic rise in worldwide vaccination rates over the past 40years, yet 19.4 million infants remain underimmunized each year. Many of these infants have received at least one vaccine dose but may remain unprotected because they did not rec...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.05.094

    authors： Guarecuco R,Lu J,McHugh KJ,Norman JJ,Thapa LS,Lydon E,Langer R,Jaklenec A

    更新日期：2018-05-24 00:00:00

  • In vivo and in vitro evidence that cross-reactive antibodies to C-terminus of hypervariable region 1 do not neutralize heterologous hepatitis C virus.

    abstract：:The hypervariable region 1 (HVR1) of hepatitis C virus (HCV) may contain neutralizing epitopes. A chimpanzee in whom cross-reactive anti-HVR1 antibodies had been induced by immunization was challenged with heterologous HCV for clarifying whether cross-reactive anti-HVR1 antibodies can neutralize heterologous HCV. Acut...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00271-2

    authors： Esumi M,Zhou YH,Tanoue T,Tomoguri T,Hayasaka I

    更新日期：2002-08-19 00:00:00

  • Mouse protection test as a predictor of the protective capacity of synthetic foot-and-mouth disease vaccines.

    abstract：:A passive immunity test (MPT) in suckling mice for the quantification of protective anti-foot-and-mouth disease virus (FMDV) antibodies in serum is described. Comparisons with titres obtained using conventional serum neutralization tests show that for cattle given synthetic peptide vaccines this in vivo assay is a bet...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(91)90311-s

    authors： Mulcahy G,Pullen LA,Gale C,DiMarchi RD,Doel TR

    更新日期：1991-01-01 00:00:00

  • Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice.

    abstract：:Protopanaxadiol saponins (Rg3, Rd, Rc, Rb1 and Rb2) and protopanaxatriol saponins (Rg1, Re and Rg2) isolated from the root of Panax ginseng C.A. Meyer were evaluated for their adjuvant effects on the immune responses to ovalbumin (OVA) in mice. BALB/c mice were subcutaneously injected twice at a 3-week interval with 1...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.054

    authors： Sun J,Hu S,Song X

    更新日期：2007-01-22 00:00:00

  • The impact of private use of PCV7 in 2009 and 2010 on serotypes and antimicrobial resistance of Streptococcus pneumoniae carried by young children in Portugal: Comparison with data obtained since 1996 generating a 15-year study prior to PCV13 introduction

    abstract：:In Portugal, the 7-valent pneumococcal conjugate vaccine (PCV7) was not introduced in the national immunization plan but was commercially available between 2001 and 2010. We studied serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae carried by children in 2009 and 2010. Vaccination with PC...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.02.045

    authors： Nunes S,Félix S,Valente C,Simões AS,Tavares DA,Almeida ST,Paulo AC,Brito-Avô A,de Lencastre H,Sá-Leão R

    更新日期：2016-03-29 00:00:00

  • Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization.

    abstract：:The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00055-8

    authors： Akari H,Suzuki T,Ikeda K,Hoshino H,Tomono T,Murotsuka T,Terao K,Ito H,Yoshikawa Y

    更新日期：1997-08-01 00:00:00

  • Macromolecular self-association of a synthetic peptide derived from the hepatitis B surface antigen: construction of a quaternary epitope.

    abstract：:A major impediment to the development of peptide vaccines has been the inability accurately to mimic conformationally constrained epitopes on the envelope proteins of pathogens. This limitation is further compounded by the fact that several viral envelope proteins exist either as covalently or non-covalently associate...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90152-a

    authors： Rao KV,Panda SK,Manivel V

    更新日期：1992-01-01 00:00:00

  • The PEDVAC trial: preliminary data from the first therapeutic DNA vaccination in HIV-infected children.

    abstract：:The PEDVAC study is the first trial designed to analyze safety and immunogenicity of a therapeutic vaccination with a multiclade multigene HIV DNA vaccine (HIVIS) in infected children. Twenty HIV-1 vertically infected children (6-16 years of age), on stable antiretroviral treatment for at least 6 months with HIV-1 RNA...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2010.12.058

    authors： Palma P,Romiti ML,Li Pira G,Montesano C,Mora N,Aquilani A,Santilli V,Tchidjou HK,Ivaldi F,Giovannelli L,Pontrelli G,Borra G,Blomberg P,Gudmundsdotter L,Bråve A,Montano M,Bernardi S,Manca F,Wahren B,Rossi P

    更新日期：2011-09-09 00:00:00

  • Vaccination with Pasteurella multocida recombinant OmpA induces strong but non-protective and deleterious Th2-type immune response in mice.

    abstract：:Pasteurella multocida OmpA (PmOmpA) belongs to the major and multifunctional Escherichia coli OmpA family of proteins. We have previously reported that the protein is conserved, immunogenic and an adhesin that binds host cells and host cell extracellular matrix molecules [Dabo SM, Confer AW, Quijano-Blas RA. Molecular...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.06.029

    authors： Dabo SM,Confer A,Montelongo M,York P,Wyckoff JH 3rd

    更新日期：2008-08-12 00:00:00

  • Genetic to genomic vaccination.

    abstract：:Our development of genetic immunization (unfortunately named 'DNA'-immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. The is particularly a ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00276-9

    authors： Johnston SA,Barry MA

    更新日期：1997-06-01 00:00:00

  • Classification of measles cases from 2014 to 2018: Implications for progress towards measles elimination in China.

    abstract：:Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.03.049

    authors： Cui A,Zhang Y,Zhu Z,Wang H,Mao N,Song J,Xu W

    更新日期：2020-05-08 00:00:00