Abstract：
:The hypervariable region 1 (HVR1) of hepatitis C virus (HCV) may contain neutralizing epitopes. A chimpanzee in whom cross-reactive anti-HVR1 antibodies had been induced by immunization was challenged with heterologous HCV for clarifying whether cross-reactive anti-HVR1 antibodies can neutralize heterologous HCV. Acute hepatitis C occurred in this chimpanzee after the challenge. Rechallenge with mixtures of the highest titer cross-reactive immune serum and heterologous HCV, after the chimpanzee had cleared the viremia, again resulted in HCV infection. Virus capture assay and inhibition of virus adsorption to susceptible cells, by the immune sera from the chimpanzee and highly cross-reactive monoclonal antibodies (mAbs) against the C-terminus of HVR1 of the challenge virus, showed that cross-reactive anti-HVR1 had no cross-neutralizing activity. The data imply that the HVR1 component is insufficient to develop an effective HCV vaccine.
journal_name
Vaccinejournal_title
Vaccineauthors
Esumi M,Zhou YH,Tanoue T,Tomoguri T,Hayasaka Idoi
10.1016/s0264-410x(02)00271-2subject
Has Abstractpub_date
2002-08-19 00:00:00pages
3095-103issue
25-26eissn
0264-410Xissn
1873-2518pii
S0264410X02002712journal_volume
20pub_type
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