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Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia.

Abstract：

:Since the prognosis of patients with Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) still remains poor, new relapse prevention strategies are needed. We evaluated the pre-immunization of mice with DNA-based vaccines subsequently challenged by the syngeneic Ph+ ALL cell line BM185. Ballistic transfer of minimalistic immunogenically defined gene expression (MIDGE) vectors encoding a BCR-ABLp185 fusion specific peptide or GM-CSF were used for in vivo transfection. DNA-based double stem-loop immunomodulators (dSLIM) were used as immune adjuvant. We present survival and functional data that DNA-based vaccination with BCR-ABLp185 fusion specific sequences, GM-CSF and dSLIM leads to an anti-tumor effect in mice challenged with a lethal Ph+ ALL dose and this effect depends on leukaemia-specific sequences.

journal_name

Vaccine

journal_title

Vaccine

authors

Köchling J,Prada J,Bahrami M,Stripecke R,Seeger K,Henze G,Wittig B,Schmidt M

doi

10.1016/j.vaccine.2008.06.094

subject

Has Abstract

pub_date

2008-08-26 00:00:00

pages

4669-75

issue

36

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00858-X

journal_volume

26

pub_type

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