Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus.

Abstract:

:A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs). In this study, CPMV-PARVO1 was inactivated by UV treatment to remove the possibility of replication of the recombinant plant virus in a plant host after manufacture of the vaccine. We show that the inactivated CVP is able to protect dogs from a lethal challenge with CPV following parenteral immunization with the vaccine. Dogs immunized with the inactivated CPMV-PARVO1 in adjuvant displayed no clinical signs of disease and shedding of CPV in faeces was limited following CPV challenge. All immunized dogs elicited high titres of peptide-specific antibody, which neutralized CPV in vitro. Levels of protection, virus shedding and VP2-specific antibody were comparable to those seen in dogs immunized with the same VP2- peptide coupled to keyhole limpet hemocyanin (KLH). Since plant virus-derived vaccines have the potential for cost-effective manufacture and are not known to replicate in mammalian cells, they represent a viable alternative to current replicating vaccine vectors for development of both human and veterinary vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Langeveld JP,Brennan FR,Martínez-Torrecuadrada JL,Jones TD,Boshuizen RS,Vela C,Casal JI,Kamstrup S,Dalsgaard K,Meloen RH,Bendig MM,Hamilton WD

doi

10.1016/s0264-410x(01)00083-4

subject

Has Abstract

pub_date

2001-06-14 00:00:00

pages

3661-70

issue

27

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(01)00083-4

journal_volume

19

pub_type

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