Tuberculosis subunit vaccine development: impact of physicochemical properties of mycobacterial test antigens.

abstract：INTRODUCTION:Information on the costs of routine immunization programs is needed for budgeting, planning, and domestic resource mobilization. This information is particularly important for countries such as Tanzania that are preparing to transition out of support from Gavi, the Vaccine Alliance. This study aimed to est...

journal_title：Vaccine

authors： Vaughan K,Clarke-Deelder E,Tani K,Lyimo D,Mphuru A,Manzi F,Schütte C,Ozaltin A

更新日期：2020-11-10 00:00:00

abstract：:Oral polio vaccine (OPV) and diphtheria-tetanus-pertussis (DTP) vaccines are given simultaneously in routine immunisation programmes in developing countries. It is therefore difficult to determine the separate effects of these vaccines on survival. We used the shortage of DTP vaccine in Bissau to examine the impact of...

journal_title：Vaccine

authors： Aaby P,Rodrigues A,Biai S,Martins C,Veirum JE,Benn CS,Jensen H

更新日期：2004-08-13 00:00:00

abstract：INTRODUCTION:New vaccine introductions have put strains on vaccine supply chains around the world. While increasing storage and transportation may be the most straightforward options, it is also important to consider what financial and operational benefits can be incurred. In 2012, suboptimal vaccine coverage and impen...

journal_title：Vaccine

authors： Brown ST,Schreiber B,Cakouros BE,Wateska AR,Dicko HM,Connor DL,Jaillard P,Mvundura M,Norman BA,Levin C,Rajgopal J,Avella M,Lebrun C,Claypool E,Paul P,Lee BY

更新日期：2014-07-07 00:00:00

abstract：INTRODUCTION:Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. In 2011, almost half of the 9943 measles cases in China occurred in children eligible for measles vaccination. We conduct...

journal_title：Vaccine

authors： Hao L,Ma C,Wannemuehler KA,Su Q,An Z,Cairns L,Quick L,Rodewald L,Liu Y,He H,Xu Q,Ma Y,Yu W,Zhang N,Li L,Wang N,Luo H,Wang H,Gregory CJ

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:Alternative methods for influenza vaccine production are needed to ensure adequate supplies. METHODS:Healthy adults 50-64 years were assigned randomly to receive one intramuscular injection of trivalent recombinant hemagglutinin (rHA) or U.S. licensed trivalent inactivated vaccine (TIV) containing H1, H3 an...

journal_title：Vaccine

authors： Baxter R,Patriarca PA,Ensor K,Izikson R,Goldenthal KL,Cox MM

更新日期：2011-03-09 00:00:00

abstract：:Active and passive immunotherapy targeting amyloid-β (Aβ) may be the most promising strategy to prevent or treat Alzheimer's disease (AD). Previously, immunization with the recombinant 6Aβ15-T antigen generated robust anti-Aβ serum antibodies that strongly recognized Aβ42 oligomers in different mice, markedly reduced ...

journal_title：Vaccine

authors： Wang HC,Yu YZ,Liu S,Zhao M,Xu Q

更新日期：2016-04-04 00:00:00

abstract：:The purpose of this study was to investigate the utility of various in vitro and in vivo methods to assess the stability of experimental vaccines containing tetanus toxoid (TT) within PLGA microspheres. In vitro, the breakdown of the encapsulating polymers into their acid components led to changes in the structure of ...

journal_title：Vaccine

authors： Sasiak AB,Bolgiano B,Crane DT,Hockley DJ,Corbel MJ,Sesardic D

更新日期：2000-11-22 00:00:00

abstract：:For humoral immunization, it may be possible to make effective and safe peptide vaccines for various diseases by selection of proper B-cell epitopes. However, a lack of T-cell epitopes on short peptides, such as those associated with major histocompatibility complex (MHC)-restriction, is a major problem for peptide va...

journal_title：Vaccine

authors： Yano A,Onozuka A,Asahi-Ozaki Y,Imai S,Hanada N,Miwa Y,Nisizawa T

更新日期：2005-03-18 00:00:00

abstract：OBJECTIVES:To determine the proportion of children whose parents prefer them to receive live, attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV), examine reasons for preferences, and determine what percentage of vaccinated children receive other than the preferred type of vaccine and why. METHO...

journal_title：Vaccine

authors： Santibanez TA,Kahn KE,Bridges CB

更新日期：2018-11-19 00:00:00

abstract：:It is generally recognized that DNA vaccines are often less effective in large animals than in mice. One possible reason for this reduced effectiveness may be transfection efficiency and the low level of expression elicited by plasmid vectors in large animals. A possible way to improve plasmid gene expression in vivo ...

journal_title：Vaccine

authors： Babiuk S,Baca-Estrada ME,Foldvari M,Storms M,Rabussay D,Widera G,Babiuk LA

更新日期：2002-09-10 00:00:00

abstract：:Plague is a zoonotic disease caused by Yersinia pestis, an etiological agent of pneumonic and bubonic plague. There is a need for an improved plague vaccine that may overcome the limitation of presently available whole cell vaccine. An alternative approach described here, is the use of protective epitopes from immunod...

journal_title：Vaccine

authors： Tripathi V,Chitralekha KT,Bakshi AR,Tomar D,Deshmukh RA,Baig MA,Rao DN

更新日期：2006-04-12 00:00:00

abstract：:Live, attenuated hepatitis A vaccines are used widely in China but there is uncertainty regarding the persistence of vaccine-induced anti-HAV antibodies after single dose and booster dose administrated at month 12. A large scale clinical trial to evaluate the live, attenuated hepatitis A vaccine was conducted in Hebei...

journal_title：Vaccine

authors： Wang XY,Xu ZY,Ma JC,von Seidlein L,Zhang Y,Hao ZY,Han OP,Zhang YL,Tian MY,Ouyang PY,Zhang ZY,Han CQ,Xing ZC,Chen JC

更新日期：2007-01-05 00:00:00

abstract：:The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there ...

journal_title：Vaccine

authors： Delbos V,Lemée L,Bénichou J,Berthelot G,Deghmane AE,Leroy JP,Houivet E,Hong E,Taha MK,Caron F,B14 STOP study group.

更新日期：2013-09-13 00:00:00

abstract：:The main objective of this study was to assess the efficacy of a monovalent inactivated vaccine containing phase I Coxiella burnetii to prevent Coxiella shedding in susceptible dairy cows within infected herds in comparison to a placebo. A total of 336 dairy cows and heifers, from six spontaneously infected herds, wer...

journal_title：Vaccine

authors： Guatteo R,Seegers H,Joly A,Beaudeau F

更新日期：2008-08-12 00:00:00

abstract：:Despite a wide array of safe and effective vaccines in use globally, with major impacts on health worldwide, the WHO Strategic Advisory Group of Experts (SAGE) on Immunization has been repeatedly confronted with reports of hesitancy towards accepting specific vaccines or vaccination programmes. This paper summarizes t...

journal_title：Vaccine

authors： Schuster M,Eskola J,Duclos P,SAGE Working Group on Vaccine Hesitancy.

更新日期：2015-08-14 00:00:00

abstract：:Brucellosis is one of the most prevalent zoonotic diseases of worldwide distribution caused by the infection of genus Brucella. Live attenuated vaccines such as B. abortus S19, B. abortus RB51 and B. melitensis Rev1 are found most effective against brucellosis infection in animals, contriving a number of serious side ...

journal_title：Vaccine

authors： Vrushabhendrappa,Singh AK,Balakrishna K,Sripathy MH,Batra HV

更新日期：2014-09-29 00:00:00

abstract：INTRODUCTION:The present study summarizes evidences of the impact that varicella vaccination (VV) introduction and coverage can have on varicella attributable hospitalization rates. METHODS:A retrospective observational study was carried out by considering hospital discharge records and VV coverage at 24 months collec...

journal_title：Vaccine

authors： Amodio E,Casuccio A,Tramuto F,Costantino C,Marrella A,Maida CM,Vitale F,Restivo V

更新日期：2020-07-31 00:00:00

abstract：INTRODUCTION:Streptococcus pneumoniae is a capsulated bacterium that can cause severe infection in patients with thalassemia major, particularly those who have undergone splenectomy. The absence of the spleen as well as zinc deficiency in splenectomized patients with thalassemia major increases the possibility of devel...

journal_title：Vaccine

authors： Sari TT,Akib AAP,Gatot D,Roswita Harahap A,Bardosono S,Hadinegoro SRS

更新日期：2017-08-16 00:00:00

abstract：:In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanof...

journal_title：Vaccine

authors： Weston WM,Friedland LR,Wu X,Howe B

更新日期：2011-01-29 00:00:00

abstract：:A new 13-valent conjugated polysaccharide vaccine (PCV13) against Streptococcus pneumoniae infections, which replaced the 7-valent vaccine (PCV7) in the regional immunization programmes for newborns and children who started but not completed the 3 doses schedule of PCV7, is available in Italy since 2010. The opportuni...

journal_title：Vaccine

authors： Boccalini S,Azzari C,Resti M,Valleriani C,Cortimiglia M,Tiscione E,Bechini A,Bonanni P

更新日期：2011-11-28 00:00:00

abstract：:Neutralizing antibody is associated with the prevention and clearance of influenza virus infection. Microneutralization (MN) and hemagglutination inhibition (HI) assays are currently used to evaluate neutralizing antibody responses against human and avian influenza viruses, including H5N1. The MN assay is somewhat lab...

journal_title：Vaccine

authors： Tsai C,Caillet C,Hu H,Zhou F,Ding H,Zhang G,Zhou B,Wang S,Lu S,Buchy P,Deubel V,Vogel FR,Zhou P

更新日期：2009-11-12 00:00:00

abstract：BACKGROUD:Influenza viruses cause substantial morbidity, especially in older age groups. Thus, they are amongst high priority groups for routine vaccination. However, vaccine-induced immune responses and effectiveness were reported as relatively low. This study aims to systemically compare the immune responses elicited...

journal_title：Vaccine

authors： Boonnak K,Dhitavat J,Thantamnu N,Kosoltanapiwat N,Auayporn M,Jiang L,Puthavathana P,Pitisuttithum P

更新日期：2017-12-19 00:00:00

abstract：:Anthrax vaccine adsorbed (AVA), an effective countermeasure against anthrax, is administered as six subcutaneous (SQ) doses over 18 months. To optimize the vaccination schedule and route of administration, we performed a prospective pilot study comparing the use of fewer AVA doses administered intramuscularly (IM) or ...

journal_title：Vaccine

authors： Pittman PR,Kim-Ahn G,Pifat DY,Coonan K,Gibbs P,Little S,Pace-Templeton JG,Myers R,Parker GW,Friedlander AM

更新日期：2002-01-31 00:00:00

abstract：BACKGROUND:Seasonal influenza infections among young children in China lead to substantial numbers of hospitalizations and financial burden. This study assessed the seasonal influenza vaccine effectiveness (VE) against laboratory confirmed medically attended influenza illness among children in Suzhou, China, from Octob...

journal_title：Vaccine

authors： Wang Y,Zhang T,Chen L,Greene C,Ding Y,Cheng Y,Yang C,Zeng S,Hua J,Zhou S,Song Y,Luan L,Zhang J,Zhao G

更新日期：2016-05-05 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) vaccination offers potential for primary prevention of HPV-related pre-cancers and cancers as demonstrated in clinical trials. Mathematical models have estimated the potential real-life impact of vaccination on the burden of cervical cancer (CC). However, these are restricted to ev...

journal_title：Vaccine

authors： Van Kriekinge G,Castellsagué X,Cibula D,Demarteau N

更新日期：2014-02-03 00:00:00

abstract：INTRODUCTION:Clinical trial data management (DM) conducted during outbreaks like that of Ebola virus disease (EVD) in West Africa, 2014-2016, has to adapt to specific, unique circumstances. CTU Bern was asked to set up a safe data capture/management system that could be launched within a few weeks and cover two differe...

journal_title：Vaccine

authors： Hossmann S,Haynes AG,Spoerri A,Diatta ID,Aboubacar B,Egger M,Rintelen F,Trelle S

更新日期：2019-11-15 00:00:00

abstract：:The ELISA method was used to titrate the humoral immune response in vaccinated mice. When mice were given two doses of a heat-killed salmonella vaccine 6 days apart, there was a steady but low-level increase of antibody synthesis. In contrast, if a booster vaccination was administered 21 days after the primary inocula...

journal_title：Vaccine

authors： Xu HR,Hsu HS,Moncure CW,King RA

更新日期：1993-01-01 00:00:00

abstract：:DNA vaccines are promising tools to fight parasitic diseases, including amoebiasis caused by the protozoan Entamoeba histolytica. Here we studied the immunogenicity and protective efficacy of a DNA vaccine against this parasite composed by the EhCPADH surface complex encoding genes (Ehcp112 and Ehadh112). EhCPADH is f...

journal_title：Vaccine

authors： Martínez MB,Rodríguez MA,García-Rivera G,Sánchez T,Hernández-Pando R,Aguilar D,Orozco E

更新日期：2009-06-24 00:00:00

abstract：:Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect ...

journal_title：Vaccine

authors： Clements A,Jenney AW,Farn JL,Brown LE,Deliyannis G,Hartland EL,Pearse MJ,Maloney MB,Wesselingh SL,Wijburg OL,Strugnell RA

更新日期：2008-10-16 00:00:00

abstract：:A qualitative study design was adapted to explore the challenges faced by health workers (HWs) during the polio health campaign. In addition, HWs' opinions about the factors causing parents to refuse oral polio vaccination (OPV) were also explored. Four focus group discussions (FGDs) were held (from 1st January 2015-3...

journal_title：Vaccine

authors： Khan TM,Sahibzada MU

更新日期：2016-04-19 00:00:00