Immunogenicity and reactogenicity of co-administered tetanus-diphtheria-acellular pertussis (Tdap) and tetravalent meningococcal conjugate (MCV4) vaccines compared to their separate administration.

Abstract:

:In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanofi-Pasteur) simultaneously or sequentially one month apart. Co-administration of Tdap+MCV4 was well tolerated and immunogenic, resulting in high levels of antibodies against diphtheria, tetanus, pertussis and meningococcal serogroup A,C,W-135 and Y antigens. The data provide support for current recommendations for co-administration of Tdap and MCV4 vaccines at the same office visit.

journal_name

Vaccine

journal_title

Vaccine

authors

Weston WM,Friedland LR,Wu X,Howe B

doi

10.1016/j.vaccine.2010.11.057

subject

Has Abstract

pub_date

2011-01-29 00:00:00

pages

1017-22

issue

5

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)01691-9

journal_volume

29

pub_type

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