当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice.

Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice.

Abstract：

:Antibodies specific for Vibrio cholerae lipopolysaccaride (LPS) are common in humans recovering from cholera, and constitute a primary component of the vibriocidal response, a serum complement-mediated bacteriocidal response correlated with protection against cholera. In order to determine whether transcutaneous immunization (TCI) with a V. cholerae neoglycoconjugate (CHO-BSA) comprised of a synthetic terminal hexasaccharide of the O-specific polysaccharide of V. cholerae O1 (Ogawa) conjugated with bovine serum albumin (BSA) could induce anti-V. cholerae LPS and vibriocidal responses, we applied CHO-BSA transcutaneously in the presence or absence of the immune adjuvant cholera toxin (CT) to mice. Transcutaneously applied neoglycoconjugate elicited prominent V. cholerae specific LPS IgG responses in the presence of CT, but not IgM or IgA responses. CT applied on the skin induced strong IgG and IgA serum responses. TCI with neoglycoconjugate did not elicit detectable vibriocidal responses, protection in a mouse challenge assay, or stool anti-V. cholerae IgA responses, irrespective of the presence or absence of CT. Our results suggest that transcutaneously applied synthetic V. cholerae neoglycoconjugate is safe and immunogenic, but predominantly induces systemic LPS responses of the IgG isotype.

journal_name

Vaccine

journal_title

Vaccine

authors

Rollenhagen JE,Kalsy A,Saksena R,Sheikh A,Alam MM,Qadri F,Calderwood SB,Kovác P,Ryan ET

doi

10.1016/j.vaccine.2009.06.040

subject

Has Abstract

pub_date

2009-08-06 00:00:00

pages

4917-22

issue

36

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00893-7

journal_volume

27

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Safety of 9-valent human papillomavirus vaccine administration among pregnant women: Adverse event reports in the Vaccine Adverse Event Reporting System (VAERS), 2014-2017.

    abstract：INTRODUCTION:9-valent human papillomavirus vaccine (9vHPV) was approved by the Food and Drug Administration (FDA) in December 2014. 9vHPV is not recommended during pregnancy, but some women of childbearing age may be inadvertently exposed. This study aims to evaluate reports submitted to the Vaccine Adverse Event Repor...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.11.077

    authors： Landazabal CS,Moro PL,Lewis P,Omer SB

    更新日期：2019-02-21 00:00:00

  • Antibody and T-cell responses to a virosomal adjuvanted H9N2 avian influenza vaccine: impact of distinct additional adjuvants.

    abstract：:A highly efficacious vaccine is required to counteract a threat of an avian influenza pandemic. Increasing the potency of vaccines by adjuvation is essential not only to overcome generally low immunogenicity of pandemic strains, but also to allow dose sparing and as such to make it feasible to satisfy huge global prod...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.04.071

    authors： Radosević K,Rodriguez A,Mintardjo R,Tax D,Bengtsson KL,Thompson C,Zambon M,Weverling GJ,Uytdehaag F,Goudsmit J

    更新日期：2008-07-04 00:00:00

  • QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans.

    abstract：:Three separate studies were undertaken in HIV-1 uninfected persons to determine if the adjuvant QS-21 improves the magnitude or kinetics of immune responses induced by recombinant soluble gp120 HIV-1(MN) protein (rsgp120) immunization. The QS-21 was administered at two doses (50 and 100 microg), either alone or in com...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0264-410x(00)00415-1

    authors： Evans TG,McElrath MJ,Matthews T,Montefiori D,Weinhold K,Wolff M,Keefer MC,Kallas EG,Corey L,Gorse GJ,Belshe R,Graham BS,Spearman PW,Schwartz D,Mulligan MJ,Goepfert P,Fast P,Berman P,Powell M,Francis D,NIAID AIDS V

    更新日期：2001-02-28 00:00:00

  • Improving immunization data quality in Peru and Mexico: Two case studies highlighting challenges and lessons learned.

    abstract：INTRODUCTION:The Global Vaccine Action Plan and the Regional Immunization Action Plan of the Americas call for countries to improve immunization data quality. Immunization information systems, particularly electronic immunization registries (EIRs), can help to facilitate program management and increase coverage. Howeve...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.10.083

    authors： Trumbo SP,Contreras M,García AGF,Díaz FAE,Gómez M,Carrión V,Ruiz KJP,Aquije R,Danovaro-Holliday MC,Velandia-González M

    更新日期：2018-11-29 00:00:00

  • Complement and antibodies: a dangerous liaison in HIV infection?

    abstract：:Due to ongoing recombination and mutations, HIV permanently escapes from neutralizing antibody (nAb) responses of the host. By the masking of epitopes or shedding of gp120, HIV-1 further impedes an efficient neutralization by Abs. Therefore, nAbs responses of the host are chasing behind a rapidly evolving virus and ma...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.11.050

    authors： Stoiber H,Soederholm A,Wilflingseder D,Gusenbauer S,Hildgartner A,Dierich MP

    更新日期：2008-12-30 00:00:00

  • Introducing cholera vaccination in Asia, Africa and Haiti: a meeting report.

    abstract：:Orally-administered cholera vaccine (OCV) has been increasingly examined as an additional tool to intervene against endemic and epidemic cholera. In 2013, short- and long-term field experience with OCV under nine distinctive field settings was reported from India, Bangladesh, Vietnam, Guinea, Haiti, and Thailand. Lead...

    journal_title：Vaccine

    pub_type：

    doi：10.1016/j.vaccine.2014.11.031

    authors： Hall RH,Sack DA

    更新日期：2015-01-15 00:00:00

  • Development of a highly immunogenic recombinant candidate vaccine against human chorionic gonadotropin.

    abstract：:Human chorionic gonadotropin (hCG) is synthesized soon after fertilization and is essential for embryonic implantation. A vaccine targeting hCG would be an ideal choice for immuno-contraception; an anti-hCG vaccine developed by Talwar et al., has previously undergone Phase II efficacy trials, providing proof of princi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.11.069

    authors： Purswani S,Talwar GP

    更新日期：2011-03-09 00:00:00

  • Regulation of CD4 T cell memory by OX40 (CD134).

    abstract：:CD4 memory T cells play a critical role in protection against repeated exposure to infectious agents such as viruses, bacteria, and helminth parasites, yet can also contribute to the aberrant immune responses associated with autoimmune and allergic reactions. Understanding the mechanisms that control effective memory ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2005.07.108

    authors： Salek-Ardakani S,Croft M

    更新日期：2006-02-13 00:00:00

  • A double-blind, placebo-controlled trial to evaluate the efficacy of PTL-003, an attenuated enterotoxigenic E. coli (ETEC) vaccine strain, in protecting against challenge with virulent ETEC.

    abstract：:Enterotoxigenic E. coli (ETEC) are an important cause of diarrhea in developing countries, especially among indigenous children and travelers. In this randomized, double-blind, placebo-controlled trial, a live, attenuated CS1/CS3 ETEC strain, PTL-003, was tested as a potential vaccine strain. Thirty-three subjects dra...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2008.06.064

    authors： McKenzie R,Darsley M,Thomas N,Randall R,Carpenter C,Forbes E,Finucane M,Sack RB,Hall E,Bourgeois AL

    更新日期：2008-08-26 00:00:00

  • Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.

    abstract：:The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.10.049

    authors： Rauw F,Gardin Y,Palya V,Anbari S,Lemaire S,Boschmans M,van den Berg T,Lambrecht B

    更新日期：2010-01-08 00:00:00

  • Near disappearance of childhood invasive Haemophilus influenzae type b disease in Singapore.

    abstract：BACKGROUND:Haemophilus influenzae type b (Hib) conjugate vaccines have significantly limited Hib's disease impact in every country where it was introduced. We previously estimated invasive Hib disease incidence in Singapore at ∼4.4 per 100,000 children <5 years (from 1994 to 2003, period 1), but the vaccine was not inc...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.08.046

    authors： Thoon KC,Tee NW,Chew L,Chong CY

    更新日期：2014-10-07 00:00:00

  • BHV-1 DNA vaccination: effect of the adjuvant RN-205 on the modulation of the immune response in mice.

    abstract：:It is well documented that adjuvants improve the immune response generated by traditional viral vaccines, but less is known about the effects of adjuvants on the immune response elicited by DNA vaccines. In this study, we have investigated the use of RN-205 (immunomodulator containing a membrane rich in lipopolysaccha...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00211-6

    authors： Zamorano P,Taboga O,Domínguez M,Romera A,Puntel M,Tami C,Mongini C,Waldner C,Palma E,Sadir A

    更新日期：2002-06-21 00:00:00

  • Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model.

    abstract：:Immunization with xenogeneic DNA is a promising cancer treatment to overcome tolerance to self-antigens. Heat shock protein 70 (HSP70) is over-expressed in various kinds of tumors and is believed to be involved in tumor progression. This study tested a xenogeneic chicken HSP70 (chHSP70) DNA vaccine in an experimental ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.02.031

    authors： Yu WY,Chuang TF,Guichard C,El-Garch H,Tierny D,Laio AT,Lin CS,Chiou KH,Tsai CL,Liu CH,Li WC,Fischer L,Chu RM

    更新日期：2011-04-18 00:00:00

  • Integration of hepatitis B vaccination into the expanded programme on immunization in Chonburi and Chiangmai provinces, Thailand.

    abstract：:Hepatitis B (HB) immunization was introduced as part of the expanded programme on immunization (EPI) in two provinces in Thailand and evaluated over a four year period. Three doses of HB vaccine were offered to 60,980 newborns at birth, 2 and 6 months of age. The overall coverage for complete HB immunization was 90.4%...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00226-5

    authors： Chunsuttiwat S,Biggs BA,Maynard J,Thamapalo S,Laoboripat S,Bovornsin S,Charanasri U,Pinyowiwat W,Kunasol P

    更新日期：1997-04-01 00:00:00

  • Effectiveness of the monovalent rotavirus vaccine in Colombia: a case-control study.

    abstract：OBJECTIVE:To assess the effectiveness of the monovalent rotavirus vaccine (RV1) to prevent rotavirus diarrhea admissions to emergency departments (ED) in Colombia. METHODS:A multicenter case-control study was carried out in six Colombian cities from 2011 to January, 2013. Cases were laboratory confirmed rotavirus diar...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2014.03.064

    authors： Cotes-Cantillo K,Paternina-Caicedo A,Coronell-Rodríguez W,Alvis-Guzmán N,Parashar UD,Patel M,De la Hoz-Restrepo F

    更新日期：2014-05-23 00:00:00

  • Porcine interleukin-3 enhances DNA vaccination against classical swine fever.

    abstract：:DNA vectors can be used to deliver vaccine antigens that stimulate effective protective immunity in mice, but in larger, outbred animal species, the protective efficacy is lower or large doses of DNA are required. These data demonstrate that porcine interleukin-3 (IL-3) when delivered to pigs by DNA vector or in low d...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.01.023

    authors： Andrew M,Morris K,Coupar B,Sproat K,Oke P,Bruce M,Broadway M,Morrissy C,Strom D

    更新日期：2006-04-12 00:00:00

  • Successful switch (tOPV to bOPV) in India: Tribute to a resilient health system.

    abstract：:In accordance with the end game strategies for polio eradication a synchronized switch plan from tOPV to bOPV was implemented globally in 2016. The National Committee for Polio Eradication (NCCPE) validated the switch activities in India. An expert group of 104 academics conducted field visits in 25 states and 2 Union...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.02.038

    authors： Dasgupta R,Sharma S,Sharma N,Banerjee K,Haran EGP,Muliyel JP,Salunke S,Masoodi MA,Haldar P,Bahl S,Bhatnagar P,Joshi S,Arora NK

    更新日期：2019-04-17 00:00:00

  • Distribution of adsorbed antigen in mono-valent and combination vaccines.

    abstract：:The distribution of alpha-casein, bovine serum albumin (BSA), myoglobin and recombinant protective antigen (rPA) in mono-valent and combination vaccines containing aluminum hydroxide adjuvant was studied by fluorescence microscopy and flow cytometry. Green and red fluorescent probes were conjugated to the antigens. Ad...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.10.040

    authors： Morefield GL,HogenEsch H,Robinson JP,Hem SL

    更新日期：2004-05-07 00:00:00

  • Pharmacist role in vaccination: Evidence and challenges.

    abstract：:Vaccines prevent an estimated 2.5 million deaths worldwide each year and are amongst the most cost-effective preventive measures against infectious diseases. Despite the effectiveness and availability of vaccines in many parts of the world, vaccination rates and service uptake remains suboptimal among both healthcare ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2019.08.060

    authors： Poudel A,Lau ETL,Deldot M,Campbell C,Waite NM,Nissen LM

    更新日期：2019-09-20 00:00:00

  • Immune responses elicited by the GEN-003 candidate HSV-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial.

    abstract：PURPOSE:GEN-003 is a candidate therapeutic HSV-2 vaccine containing a fragment of infected cell protein 4 (ICP4.2), a deletion mutant of glycoprotein D2 (gD2ΔTMR), and Matrix-M2 adjuvant. In a dose-ranging phase 1/2a clinical trial, immunization with GEN-003 reduced viral shedding and the percentage of reported herpeti...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2016.09.001

    authors： Flechtner JB,Long D,Larson S,Clemens V,Baccari A,Kien L,Chan J,Skoberne M,Brudner M,Hetherington S

    更新日期：2016-10-17 00:00:00

  • Penton base induces better protective immune responses than fiber and hexon as a subunit vaccine candidate against adenoviruses.

    abstract：:Human adenoviruses (AdVs) have been extensively studied as vectors for gene therapy and vaccination. However, little attention has been paid to AdV vaccine development and treatment. Currently, there is a lack of information concerning the immunogenicity of AdV major capsid proteins. Here, using AdV7 as a model, we co...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.05.118

    authors： Hu K,Fu M,Guan X,Zhang D,Deng X,Xiao Y,Chen R,Liu H,Hu Q

    更新日期：2018-07-05 00:00:00

  • Attitudes towards vaccination against seasonal influenza of health-care workers in primary health-care settings in Greece.

    abstract：:Vaccination of health-care workers (HCWs) against seasonal influenza has been consistently recommended worldwide in order to prevent nosocomial transmission and ensure delivery of health-care services during outbreaks. We describe the effects of a nationwide campaign to promote influenza vaccination among HCWs working...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.06.108

    authors： Dedoukou X,Nikolopoulos G,Maragos A,Giannoulidou S,Maltezou HC

    更新日期：2010-08-23 00:00:00

  • New strategies for closing the gap of measles susceptibility in infants: towards vaccines compatible with current vaccination schedules.

    abstract：:Peptides representing epitopes of the measles virus glycoproteins have been designed to induce neutralizing and protective antibodies. Those that escape recognition by passively acquired anti-whole virus antibodies could potentially be used as components of a 'pre-vaccine' that could be given during early childhood ir...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(00)00452-7

    authors： El Kasmi KC,Muller CP

    更新日期：2001-03-21 00:00:00

  • Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.

    abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.11.015

    authors： Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

    更新日期：2019-01-03 00:00:00

  • HBV-vaccination in recipients of kidney allografts.

    abstract：:Recipients of renal transplants were vaccinated with 20 ng hepatitis B surface antigen aluminium-adsorbed vaccine in order to gauge their resistance to hepatitis B infection, to which these patients are at high risk. The patients were given three 40 micrograms doses of the vaccine over a period of six months and their...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0264-410x(84)90039-2

    authors： Feuerhake A,Muller R,Lauchart W,Pichlmayr R,Schmidt FW

    更新日期：1984-12-01 00:00:00

  • Vaccination-induced HI antibody to influenza A(H1N1) viruses in poorly primed adults under circumstances of low antigenic drift.

    abstract：:In Autumn 1990, trivalent split influenza virus vaccine containing A/Taiwan/1/86(H1N1) was used to immunize healthy female employees (n = 104). The 11-12 amino acid differences in the HA1 domain of virus haemagglutinin between A/Taiwan/1/86 and representative epidemic H1N1 strains in Finland in 1991 did not result in ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(93)90126-i

    authors： Pyhälä R,Kinnunen L,Kumpulainen V,Ikonen N,Kleemola M,Cantell K

    更新日期：1993-01-01 00:00:00

  • Overcoming barriers to HPV vaccination: non-inferiority of antibody response to human papillomavirus 16/18 vaccine in adolescents vaccinated with a two-dose vs. a three-dose schedule at 21 months.

    abstract：:For middle and low-income countries, the cost of HPV vaccines remains challenging. We conducted an open-label nonrandomized clinical trial evaluating immune response to the HPV-16/18 AS04-adjuvanted vaccine administered on a standard (months (M) 0-1-6) versus extended schedule (M 0-6-60) at 7, 21, 60, 72 and 120 month...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.vaccine.2013.11.059

    authors： Lazcano-Ponce E,Stanley M,Muñoz N,Torres L,Cruz-Valdez A,Salmerón J,Rojas R,Herrero R,Hernández-Ávila M

    更新日期：2014-02-03 00:00:00

  • Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing com

    abstract：:Genetic diversity and hypermutation contribute to difficulties in developing a vaccine against viruses like HIV and influenza. There are currently no known immune correlates of protection against HIV. This has made the development of a vaccine against HIV that would provide sterilizing immunity in the near future an i...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2007.12.008

    authors： Kotwal GJ

    更新日期：2008-06-06 00:00:00

  • Preclinical development of a dengue tetravalent recombinant subunit vaccine: Immunogenicity and protective efficacy in nonhuman primates.

    abstract：:We describe here the preclinical development of a dengue vaccine composed of recombinant subunit carboxy-truncated envelope (E) proteins (DEN-80E) for each of the four dengue serotypes. Immunogenicity and protective efficacy studies in Rhesus monkeys were conducted to evaluate monovalent and tetravalent DEN-80E vaccin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.06.067

    authors： Govindarajan D,Meschino S,Guan L,Clements DE,ter Meulen JH,Casimiro DR,Coller BA,Bett AJ

    更新日期：2015-08-07 00:00:00

  • Trivalent inactivated influenza vaccine (IIV3) during pregnancy and six-month infant development.

    abstract：OBJECTIVE:Despite recommendations by professional organizations that all pregnant women receive inactivated influenza vaccine, safety concerns remain a barrier. Our objective was to assess the effect of trivalent influenza vaccines (IIV3) during pregnancy on parent report 6-month infant development. METHODS:We conduct...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.01.059

    authors： Avalos LA,Ferber J,Zerbo O,Naleway AL,Bulkley J,Thompson M,Cragan J,Williams J,Odouli R,Kauffman TL,Ball S,Shifflett P,Li DK

    更新日期：2020-02-28 00:00:00